UID:
almafu_9958116396602883
Umfang:
1 online resource (110 pages) :
,
illustrations; digital, PDF file(s).
ISBN:
9782889193080 (ebook)
Serie:
Frontiers Research Topics
Inhalt:
Oncolytic viruses (OVs) have emerged as a promising anticancer treatment. OVs selectively infect, replicate in, and kill tumor cells. Oncolytic viral therapy occurs in two phases: an initial phase where the virus mediates direct oncolysis of tumor cells, and a second phase where an induced post-oncolytic immune response continues to mediate tumor destruction and retards progression of the disease. For a long time, the therapeutic efficacy was thought to depend mainly on the direct viral oncolysis based on their tumor selective replication and killing activities. But the post-oncolytic anti-tumor activity induced by the OV therapy is also a key factor for an efficient therapeutic activity. The topic addresses various strategies how to optimize OVs anti-tumor activity.
Anmerkung:
Bibliographic Level Mode of Issuance: Monograph
,
English
Sprache:
Englisch
