UID:
almafu_9959076713902883
Umfang:
1 online resource (185 p.)
ISBN:
9786613153869
,
9781283153867
,
1283153866
,
9783805596107
,
3805596103
Serie:
Frontiers of gastrointestinal research,
Inhalt:
There is a growing body of experimental and clinical data to suggest that the organs of the digestive system may be subjected to considerable oxidative stress associated with acute and chronic inflammation. Although inflammation and ischemia play a key role in producing oxygen-derived free radicals in the digestive tract, the contribution of other factors, such as transition metal imbalances, lipid and glucose metabolic disturbance, and the interaction with gaseous molecules including nitric oxide and carbon monoxide, has also been suggested. Recent studies have demonstrated that several biomarkers indicating oxidative stress-mediated damage may help in monitoring the degree of disease and planning the design of new therapeutic strategies. In addition, recent advances in ‘omics’ research (genomics, proteomics, metabolomics, etc.) may bring a breakthrough in the field of gastroenterology and hepatology: Several molecular targets for oxidative stress have been presented by the ‘omics’. This book includes up-to-date reviews on the relevant issues in free radical biology in a combination with expert basic research reviews and clinical aspects in gastroenterology and hepatology. Providing information about new molecular targets for the treatment or prevention of digestive diseases, this book should be read by clinical and basic researchers in gastroenterology and hepatology.
Anmerkung:
Description based upon print version of record.
,
""Cover""; ""Contents""; ""Preface""; ""References""; ""Free Radical Biology""; ""Free Radicals and Lipid Peroxidation""; ""Abstract""; ""Mechanisms and Products of Lipid Peroxidation""; ""Secondary Products of Lipid Peroxidation""; ""Lipid Peroxidation Products as Biomarker for Oxidative Stress in vivo""; ""References""; ""Mitochondria as Source of Free Radicals""; ""Abstract""; ""Superoxide Theory""; ""Emergence of Mitochondria as the Major Mediators of Apoptosis""; ""Mitochondrial Electron Transport Chain and Superoxide Production""
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""ROS Generation by Mitochondria in Cells with Impaired ETC""""Reactive Oxygen Species Generation by Mitochondria in Cells with Mitochondrial DNA Damage""; ""References""; ""The Nox Family of NADPH Oxidases that Deliberately Produce Reactive Oxygen Species""; ""Abstract""; ""Structure of Nox Family NADPH Oxidases""; ""Expression, Function, and Regulation of gp91phox/Nox2""; ""Expression and Regulation of Nox1""; ""Expression, Function, and Regulation of Nox3""; ""Expression and Regulation of Nox4""; ""Expression and Regulation of Nox5""
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""Expression, Function, and Regulation of Duox1 and Duox2""""Nox Family Oxidases in Digestive Diseases""; ""Acknowledgements""; ""References""; ""Neutrophil- Dependent Oxidative Stress in Inflammatory Gastrointestinal Diseases""; ""Abstract""; ""Molecular Mediators in Neutrophil Infiltration""; ""Neutrophil Activation in Gastrointestinal Diseases""; ""Neutrophil- Dependent Mucosal Injury""; ""Conclusion""; ""Acknowledgment""; ""References""; ""Oxidative DNA Damage and Carcinogenesis""; ""Abstract""; ""The History of Free Radical Chemistry""; ""Reactive Oxygen Species""
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""Antioxidant Systems""""Oxidative Stress and DNA""; ""Oxidative DNA Damage and Carcinogenesis""; ""Oxygenomics""; ""Conclusions""; ""Acknowledgements""; ""References""; ""Plasma Marker of Oxidative Stress in Circulation and in Tissue""; ""Abstract""; ""What Is the Most Sensitive Marker of Oxidative Stress?""; ""Plasma Marker of Cellular Oxidative Stress""; ""Assessment of Plasma Marker of Oxidative Stress in Rat Brain Damage Model""; ""References""; ""Immunochemical Detection of 4- Hydroxy- 2-Nonenal- Specific Epitopes""; ""Abstract""; ""4- Hydroxy- 2- Nonenal- Specific Adducts""
,
""Immunochemical Detection of HNE- Specific Epitopes""""Conclusion""; ""References""; ""Carbon Monoxide- Dependent Regulation of Microvascular Function: One Gas Regulates Another""; ""Abstract""; ""Carbon Monoxide as a Vasorelaxing Gas Discovered in the Liver""; ""Vasoconstrictive Properties of CO in Brain Microcirculation""; ""Cystathionine β- Synthase as a CO Sensor in vivo""; ""Heme Oxygenase- 2: An O2 Sensor in Neurovascular Systems?""; ""Acknowledgments""; ""References""; ""Nrf2-Keap1 Signaling as a Common Chemopreventive Target of Antioxidative and Anti-Inflammatory Phytochemicals""
,
""Abstract""
,
English
Weitere Ausg.:
ISBN 9783805596091
Weitere Ausg.:
ISBN 380559609X
Sprache:
Englisch
