UID:
almafu_9959076715902883
Umfang:
1 online resource (135 p.)
ISBN:
9783318021714
,
3318021717
Serie:
Else Kroner-Fresenius symposia,
Inhalt:
Adult stem cells are present in most postnatal tissues of mammals. Tissues with high rates of cell turnover depend on the functional capacity of stem cells for lifelong maintenance of tissue homeostasis. Adult stem cells are also required for the regeneration of tissues in response to injury as in, for example, the regeneration of skeletal muscle. In addition to its function in tissue homeostasis and regeneration, adult stem cells can represent the cell type of origin of various types of cancers including leukemia and colorectal cancer. Stem cells are the most long-lived cells in the proliferative compartment of mammalian tissues. Therefore, stem cells have an increased risk of acquiring mutations that could ultimately lead to the transformation of tissue stem cells. This publication presents the current knowledge in the field of stem cell aging, which was discussed at the Else Kröner-Fresenius Symposium on Advances in Stem Cell Aging in 2011. It will be of special interest to scientists working on stem cell research, aging, regeneration, and cancer as well as physicians and scientists specializing in geriatric medicine, internal medicine, and surgery.
Anmerkung:
Description based upon print version of record.
,
""Adhesion Is Central to Stem Cell-Niche Interactions""""References""; ""Chapter 3: Hematopoietic Stem Cell Aging and Cancer""; ""Abstract""; ""Stem Cell Dormancy and Cancer""; ""Stem Cell Fate Decision and Cancer""; ""Stem Cell Fate Decision and DNA Methylation""; ""Human Stem Cell Aging""; ""Conclusion and Outlook""; ""References""; ""Chapter 4: DNA Damage, Checkpoint Responses, and Cell Cycle Control in Aging Stem Cells""; ""Abstract""; ""The Role of DNA Repair in Maintenance of Epidermal Stem Cells""; ""Emerging Role of Polycomb Repressors in DNA Damage Response and Repair""
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""DNA Damage and Aging of Hematopoietic Stem Cells""""A New Model for Hematopoietic Stem Cell Aging""; ""A Novel Checkpoint Induces Lymphoid Differentiation in Hematopoietic Stem Cells after DNA Damage""; ""Regulation of p53 Activity in Hematopoietic Stem Cell Homeostasis""; ""Conclusion""; ""References""; ""Chapter 5: Hematopoietic Stem Cell Aging and Fate Decision""; ""Abstract""; ""Characteristics of the Hematopoietic Stem Cell""; ""Functional Changes of Hematopoietic Stem Cells during Aging""; ""Immunophenotype Changes of Hematopoietic Stem Cells during Aging""
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""Epigenetic Regulation of Stem Cell Function""""DNA Damage Signaling in the Regulation of Hematopoietic Stem Cells""; ""Dissecting Age-Dependent Effects on Hematopoiesis in Recombinant Inbred Mouse Strains""; ""Regulatory Pathways in Quiescence and Self-Renewal of Hematopoietic Stem Cells""; ""Genes Controlling Quiescence and Self-Renewal of Hematopoietic Stem Cells""; ""Regulation of Dormant Hematopoietic Stem Cells""; ""Conclusion""; ""References""; ""Chapter 6: Stem Cell Therapy and Stress Response in Pancreas and Intestine""; ""Abstract""; ""Introduction""
,
""Stress Response in the Aging Intestine""
,
English
Weitere Ausg.:
ISBN 9783318021707
Weitere Ausg.:
ISBN 3318021709
Sprache:
Englisch
