UID:
almafu_9959327517402883
Umfang:
1 online resource (641 pages)
ISBN:
9783527630943
,
3527630945
,
9783527630950
,
3527630953
,
9783527318117
,
3527318119
Serie:
Methods and principles in medicinal chemistry
Inhalt:
In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part provides a general introduction to the family of aspartic acid proteases, their physiological functions, molecular structure and inhibition. Parts two to five present various case studies of successful protease inhibitor drug design and development, as well as current and potential uses of such inhibitors in pharmaceutical medicine, covering the major therapeutic targets HIV-1 protease, renin, beta-secretase, gamma-secretase, plasmepsins and fungal.
Anmerkung:
Overview of Aspartic Acid Proteases. Introduction to the Aspartic Proteinase Family / Ben M Dunn -- Aspartic Proteases: Structure, Function, and Inhibition / Jordan Tang -- Human Aspartic Proteinases / John Kay, Daniel Bur -- Structure-Based Drug Design Strategies for Inhibition of Aspartic Proteinases / Jon B Cooper -- HIV-1 Protease as Target for the Treatment of HIV/AIDS. HIV-1 Protease: Role in Viral Replication, Protein-Ligand X-Ray Crystal Structures and Inhibitor Design / Irene T Weber, Yuan-Fang Wang -- First-Generation HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS / Scott C Virgil -- Second-Generation Approved HIV Protease Inhibitors for the Treatment of HIV/AIDS / Arun K Ghosh, Bruno D Chapsal -- Darunavir, a New PI with Dual Mechanism: From a Novel Drug Design Concept to New Hope against Drug-Resistant HIV / Arun K Ghosh, Bruno D Chapsal, Hiroaki Mitsuya -- Development of HIV-1 Protease Inhibitors, Antiretroviral Resistance, and Current Challenges of HIV/AIDS Management / Hiroaki Mitsuya, Arun K Ghosh -- Renin as Target for the Treatment of Hypertension. Discovery and Development of Aliskiren, the First-in-Class Direct Renin Inhibitor for the Treatment of Hypertension / Jeanette M Wood, Jurgen Maibaum -- Evolution of Diverse Classes of Renin Inhibitors through the Years / Colin M Tice, Suresh B Singh -- [beta]-Secretase as Target for the Treatment of Alzheimer's Disease. [beta]-Secretase: An Unusual Enzyme with Many Possible Disease Targets, Including Alzheimer's Disease / Johan Lundkvist, Urban Lendahl -- [beta]-Secretase Inhibition: An Overview of Development of Inhibitors for the Treatment of Alzheimer's Disease / Christopher L Hamblett, Sanjiv Shah, Richard Heidebrecht, Benito Munoz -- [beta]- Secretase as Target for the Treatment of Alzheimer's Disease. BACE: A (Almost) Perfect Target for Staving off Alzheimer's Disease / Sukanto Sinha -- The Discovery of [beta]- Secretase and Development toward a Clinical Inhibitor for AD: An Exciting Academic Collaboration / Jordan Tang, Lin Hong, Arun K Ghosh -- Peptidomimetic BACE1 Inhibitors for Treatment of Alzheimer's Disease: Design and Evolution / Ulrich Iserloh, Jared N Cumming -- Nonpeptide BACE1 Inhibitors: Design and Synthesis / Derek C Cole, Matthew G Bursavich -- Plasmepsins and Other Aspartic Proteases as Drug Targets. The Plasmepsin Family as Antimalarial Drug Targets / Adam J Ruben, Yoshiaki Kiso, Ernesto Freire -- Plasmepsins Inhibitors as Potential Drugs against Malaria: Starving the Parasite / Sandra Gemma -- Fungal Aspartic Proteases as Possible Therapeutic Targets / Michel Monod, Peter Staib, Utz Reichard, Olivier Jousson -- Index.
Weitere Ausg.:
Print version: Ghosh, Arun K. Aspartic Acid Proteases as Therapeutic Targets. Weinheim : Wiley-VCH, 2010 ISBN 9783527630950
Sprache:
Englisch
Schlagwort(e):
Electronic books.
;
Electronic books.
;
Electronic books.
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9783527630943
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9783527630943
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9783527630943
