UID:
almafu_9959328238102883
Format:
1 online resource (xiv, 346 pages)
Edition:
2nd ed.
ISBN:
9780470689332
,
0470689331
,
9780470689349
,
047068934X
Content:
(Publisher-supplied data) Human Drug Metabolism, An Introduction, Second Edition provides an accessible introduction to the subject and will be particularly invaluable to those who already have some understanding of the life sciences. Completely revised and updated throughout, the new edition focuses only on essential chemical detail and includes patient case histories to illustrate the clinical consequences of changes in drug metabolism and its impact on patient welfare. After underlining the relationship between efficacy, toxicity and drug concentration, the book then considers how metabolizing systems operate and how they impact upon drug concentration, both under drug pressure and during inhibition. Factors affecting drug metabolism, such as genetic polymorphisms, age and diet are discussed and how metabolism can lead to toxicity is explained. The book concludes with the role of drug metabolism in the commercial development of therapeutic agents as well as the pharmacology of some illicit drugs.
Note:
Front Matter -- Introduction -- Drug Biotransformational Systems-Origins and Aims -- How Oxidative Systems Metabolize Substrates -- Induction of Cytochrome P450 Systems -- Cytochrome P450 Inhibition -- Conjugation and Transport Processes -- Factors Affecting Drug Metabolism -- Role of Metabolism in Drug Toxicity -- Appendix A: Methods in Drug Metabolism -- Appendix B: Metabolism of Major Illicit Drugs -- Appendix C: Examination Techniques -- Appendix D: Summary of Major CYP Isoforms and their Substrates, Inhibitors and Inducers -- Suggested Further Reading -- Index.
Additional Edition:
Print version: Coleman, Michael D. Human drug metabolism. Oxford ; Hoboken, NJ : Wiley-Blackwell, ©2010 ISBN 9780470742174
Additional Edition:
ISBN 0470742178
Language:
English
Keywords:
Electronic books.
;
Electronic books.
DOI:
10.1002/9780470689332
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9780470689332
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9780470689332
