UID:
almafu_9959328706602883
Format:
1 online resource
ISBN:
9781118847015
,
1118847016
,
9781118846940
,
111884694X
,
9781118847237
,
1118847237
,
1118125657
,
9781118125656
Content:
"This important reference provides up-to-date information on all aspects of ribosome-inactivating proteins (RIPs). Including a list of all known RIPs, their distribution in nature, structure, genetics and chemical and immunological properties, this reference covers mechanisms of action, including the enzymatic activity on various polynucleotide substrates; the interaction with, and entry into cells; the toxicity to animals, including the pathology of poisoning; and the immunomodulatory and allergenic activity. The book further emphasizes the use of immunotoxins and other conjugates in clinical trials for the therapy of cancer and intractable pain"--
Content:
"Ribosome-inactivating Proteins is a reference book which will provide up-to-date information on all aspects of ribosome-inactivating proteins (RIPs)"--
Note:
"Title page"; "Copyright page"; "Contributors"; "Preface"; "1 Introduction and History"; "Introduction"; "Identification and Distribution in Nature"; "Mechanism of Action"; "Effects on Cells and Animals"; "Role in Nature"; "Practical Applications"; "Bioweapons"; "Future Challenges"; "References"; "2 Occurrence and Taxonomical Distribution of Ribosome-inactivating Proteins Belonging to the Ricin/Shiga Toxin Superfamily"; "Introduction"; "How to Investigate the Distribution of Proteins with an N-glycosidase Domain?"; "Conclusions"; "Acknowledgments."
,
"Introduction""Family Sambuceae"; "Type 2 RIPs from Other families"; "Uses of nontoxic type 2 RIPs"; "Concluding remarks"; "Acknowledgment"; "References"; "6 The Intracellular Journey of Type 2 Ribosome-inactivating Proteins"; "Introduction"; "Cell Surface Events"; "Endosome to TGN Sorting"; "From the Golgi to the ER"; "Reductive Separation and Destabilization of the Holotoxin Subunits"; "Dislocation Across the ERâ€0 embrane"; "Cytosolic Post-dislocation Events that Restore Catalytic Activity"; "Concluding Remarks"; "Acknowledgements"; "References."
,
"7 Shiga Toxins""Introduction"; "Purification of Shiga Toxins"; "Structure and Mechanism of Action of Shiga Toxins"; "Role of Shiga Toxins in the Pathogenesis of HUS"; "The 2011 German STEC Outbreak"; "References"; "8 The Structure and Action of Ribosome-inactivating Proteins"; "Introduction"; "Acknowledgments"; "References"; "9 Updated Model of the Molecular Evolution of RIP Genes"; "Introduction"; "Important Issues to be Considered in View of the Evolution of RIP Genes."
,
"Dissecting RIP Genes and RIP Gene Families by in silico Analysis of Genome and Transcriptome Data""New Insights in the Overall Phylogeny of Plant RIPs"; "An Updated Model of the Molecular Evolution of the Plant RIP Gene Family"; "What is the Evolutionary Link Between Plant and Non-Plant RIPs?"; "Conclusions"; "References"; "10 Enzymology of the Ribosome-inactivating Proteins"; "Introduction"; "Ricin as RNA N-glycosidase"; "Role of SRL in Ribosomes"; "Ribosomal RNA Apurinic Site-specific Lyase â€" Intrinsic Stability of the Ribosomes"; "Action of RIPs on DNA."
Additional Edition:
Print version: Ribosome-inactivating proteins. Ames, Iowa : John Wiley & Sons Inc., 2014 ISBN 9781118125656
Language:
English
Keywords:
Electronic books.
;
Electronic books.
;
Electronic books.
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9781118847237
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9781118847237
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9781118847237
