UID:
almafu_9959328721302883
Umfang:
1 online resource (xx, 242 pages) :
,
illustrations
ISBN:
3527605517
,
9783527605514
,
3527601813
,
9783527601813
Serie:
Methods and principles in medicinal chemistry ; v. 19
Inhalt:
The lock-and-key principle formulated by Emil Fischer as early as the end of the 19th century has still not lost any of its significance for the life sciences. The basic aspects of ligand-protein interaction may be summarized under the term 'molecular recognition' and concern the specificity as well as stability of ligand binding. Molecular recognition is thus a central topic in the development of active substances, since stability and specificity determine whether a substance can be used as a drug. Nowadays, computer-aided prediction and intelligent molecular design make a large contribution.
Anmerkung:
Protein-Ligand Interactions From Molecular Recognition to Drug Design; Contents; Preface; A Personal Foreword; List of Contributors; List of Abbreviations; Prologue; 1 Prediction of Non-bonded Interactions in Drug Design; 2 Introduction to Molecular Recognition Models; 3 Experimental Approaches to Determine the Thermodynamics of Protein-Ligand Interactions; 4 The Biophore Concept; 5 Receptor-Ligand Interaction; 6 Hydrogen Bonds in Protein-Ligand Complexes; 7 Principles of Enzyme-Inhibitor Design; 8 Tailoring Protein Scaffolds for Ligand Recognition.
,
English.
Weitere Ausg.:
Print version: Protein-ligand interactions from molecular recognition to drug design. Weinheim : Wiley-VCH, ©2003 ISBN 3527305211
Sprache:
Englisch
Schlagwort(e):
Electronic books.
;
Electronic books.
;
Electronic books.
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/3527601813
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/3527601813
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/3527601813
