UID:
almafu_9959329145702883
Format:
1 online resource (734 pages)
ISBN:
9783527630905
,
3527630902
,
9783527329038
,
352732903X
,
9783527630912
,
3527630910
,
9783527646326
,
3527646329
,
9783527646333
,
3527646337
,
9781280665653
,
1280665653
Content:
A practice-oriented desktop reference for toxicologists and pharmaceutical researchers, this handbook provides systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part briefly reviews the main enzyme systems involved in biotransformation and how they are orchestrated in the body, while parts two to four cover the three main classes of xenobiotics: drugs, natural products, environmental pollutants. Selected, well-documented case studies from the most important xenobiotics classes illustrate general principles of metabolism, making this.
Note:
Front Matter -- Biochemistry and Molecular Genetics of Drug Metabolism. Drug-Metabolizing Enzymes₆An Overview / Pavel Anzenbacher, Eva Anzenbacherov̀ -- Cytochromes P450 / F Peter Guengerich -- UDP-Glucuronosyltransferases / Christian P Strassburg, Sandra Kalthoff -- Sulfotransferases / Michael W H Coughtrie -- Glutathione -Transferases / Miroslav Dostalek, Anna-Katarina Stark -- Hydrolytic Enzymes / Bingfang Yan -- Transporting Systems / Anne T Nies, Claudia Resch, Tadashi Namisaki -- Transcriptional Regulation of Human Drug-Metabolizing Cytochrome P450 Enzymes / Zdenek Dvorak -- Importance of Pharmacogenomics / Ulrich M Zanger, Kathrin Klein, Jessica Rieger -- Metabolism of Drugs. Introduction to Drug Metabolism / Ulrich M Zanger -- Central Nervous System Drugs / Pierre Baumann, Christoph Hiemke -- Cardiovascular Drugs / Stephan Riedmaier, Ulrich M Zanger -- Anticancer Drugs / Matthias Schwab, Elke Schaeffeler, Hiltrud Brauch -- Antimicrobial Agents / Chantal Csajka, Oscar Marchetti, Oriol Manuel, Laurent Decosterd, Amalio Telenti -- Drugs against Acute and Chronic Pain / Andrew A Somogyi, Janet K Coller -- Drugs of Abuse (Including Designer Drugs) / Markus R Meyer, Hans H Maurer -- Nicotine Metabolism and its Implications / Andy Z X Zhu, Rachel F Tyndale -- Metabolism of Alcohol and its Consequences / Helmut K Seitz, Sebastian Mueller -- Metabolism of Natural Compounds. Introduction and Overview / Michael Murray -- Flavonoids / Petr Hodek -- St John's Wort (L.) / Miroslav Dostalek, Anna-Katarina Stark -- Food Components and Supplements / Alexandr Parlesak -- Metabolism of Unnatural Xenobiotics. Environmental Pollutants / Marie Stiborova -- Environmental Estrogens / Miroslav Machala, Jan Vondr̀cek -- Biotransformation of Insecticides / Corie A Ellison, Alice L Crane, James R Olson -- Index.
Additional Edition:
Print version: Metabolism of drugs and other xenobiotics. Weinheim : Wiley-VCH, 2012 ISBN 9783527329038
Language:
English
Subjects:
Chemistry/Pharmacy
Keywords:
Electronic books.
;
Electronic books.
;
Electronic books.
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9783527630905
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9783527630905
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9783527630905
