UID:
almafu_9959329177902883
Format:
1 online resource (xvii, 524 pages, 12 unnumbered pages of plates) :
,
illustrations (some color)
ISBN:
9781444312089
,
1444312081
,
9781405176293
,
1405176296
,
9781405194105
,
1405194103
Content:
The importance of metal-DNA interactions in living systems, and their potential applications especially in the treatment and diagnosis of diseases has stimulated considerable recent interest in this area. The most important application is the antitumour action of certain heavy metals, which work by binding to and distorting DNA, causing cell death. For example, Cisplatin (Cl2H6N2Pt) is one of the most potent and widely used anticancer drugs in use today. This book provides an overview of metal-DNA interactions, the mechanism of their interaction, metal-based drugs and metal ion toxicity. It i.
Note:
Sequence-selective binding of transition metal complexes to DNA / Einar Sletten and Nils Åge Frøystein -- Thermodynamic models of metal ion-DNA interactions / Vasil Bregadze, Eteri Gelagutashvili and Ketevan Tsakadze -- Metal ion coordination in G-quadruplexes / Janez Plavec -- Supramolecular chemistry of metal-nucleobase complexes / P.J. Sanze Miguel [and others] -- Platinum drugs, nucleotides and DNA : the role of interligand interactions / Giovanni Natile and Francesco Cannito -- Role of DNA repair in antitumour effects of platinum drugs / Viktor Brabec and Jana Kašpárková -- Telomeres and telomerase : potential targets for platinum complexes / Isabell Ourliac-Garnier, Razan Charif and Sophie Bombard -- Towards photodynamic therapy of cancer with platinum group metal polyazine complexes / David F. Zigler and Karen J. Brewer -- Platinated oligonucleotides : synthesis and applications for the control of gene expression / Vicente Marchán and Anna Grandas.
,
Rhodium- and tin-DNA interactions and applications / Kenneth D. Camm and Patrick C. McGowan -- Groove-binding ruthenium(II) complexes as probes of DNA recognition / Jayden A. Smith, J. Grant Collins and F. Richard Keene -- DNA recognition and binding by peptide-metal complex conjugates / Alexandra Myari and Nick Hadjiliadis -- Artificial restriction agents : hydrolytic agents for DNA cleavage / Fabrizio Mancin and Paolo Tecilla -- New metallo-DNAzymes : fundamental studies of metal-DNA interactions and metal sensing applications / Zehui Cao and Yi Lu -- Two-metal-ion-dependent catalysis in nucleic acid enzymes / Wei Yang -- Structural studies on the mercury-mediated T-T base-pair using NMR spectroscopy / Yoshiyuki Tanaka and Akira Ono -- Chromium-induced DNA damage and repair / Laura G. Little and Kent D. Sugden -- Arsenic induced carcinogenicity : new insights in molecular mechanism / Andrea Hartwig and Tanja Schwerdtle.
Additional Edition:
Print version: Metal complex-DNA interactions. Chichester, West Sussex, U.K. : Wiley, 2009 ISBN 9781405176293
Additional Edition:
ISBN 1405176296
Language:
English
Keywords:
Electronic books.
;
Aufsatzsammlung.
;
Electronic books.
;
Aufsatzsammlung.
;
Electronic books.
;
Aufsatzsammlung.
DOI:
10.1002/9781444312089
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9781444312089
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9781444312089
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9781444312089
