UID:
almafu_9960072237702883
Umfang:
1 online resource (547 p.)
ISBN:
1-281-01071-5
,
9786611010713
,
0-08-049379-3
Serie:
Advances in protein chemistry, v. 68
Inhalt:
Cell Surface Receptors contains an extensive discussion of cell surface receptors in 11 chapters by experts in their field. As cell surface receptors are involved in almost every aspect of signaling throughout the body, the topic has been of high interest in the community in recent years.Selected Contents:-Structures of Axon Guidance Molecules and Their Neuronal Receptors-Shared Cytokine Signaling Receptor-NKG2D and Related Immunoreceptors-Inonotropic Glutamat Receptor Recognition and Activation-Chemotaxis Receptors and Signaling
Anmerkung:
Description based upon print version of record.
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Cover; Contents; Preface; Chapter 1. Structure and Function of the Epidermal Growth Factor (EGF/ErbB) Family of Receptors; I. Introduction; II. The EGF and EGFR Families; III. Association of ErbB Receptors with Human Disease; IV. Structure of Individual ErbB Receptor Domains; V. Structure of Entire ErbB Receptor Ectodomains; VI. HER2; VII. Therapeutic Anti-HER2 Antibodies; VIII. Remaining Questions; References; Chapter 2. The Three-Dimensional Structure of Integrins and Their Ligands, and Conformational Regulation of Cell Adhesion; I. Introduction
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II. Conformational Regulation of Integrin Structure and FunctionIII. Integrin/Ligand Interactions; References; Chapter 3. Structures of Axon Guidance Molecules and Their Neuronal Receptors; I. Introduction; II. Eph Receptors and Ephrins; III. Semaphorins, Neuropilins, and Plexins; IV. Myelin-Associated Inhibitors of Axonal Regeneration; V. Conclusion and Perspectives; References; Chapter 4. Shared Cytokine Signaling Receptors: Structural Insights from the gp130 System; I. Cross-Reactive Signaling Receptors in Biology; II. Cytokines and Receptors
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III. The Growth Hormone Paradigm: Generalities and LimitationsIV. Shared Signaling Receptors for Hematopoietic Cytokines; V. gp130 Family of Cytokines and Receptors; VI. A Structural Basis of gp130 Cross Reactivity: Site II; VII. Thermodynamic Basis for a Universal Binding Solution; VIII. Cross-Reactivity of the gp130 IGD with Cytokine Site III; IX. Predicting the Higher-Order Assemblies of the Asymmetric Complexes (gp130/LIFR); X. Translating Ligand Recognition into Signaling; References
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Chapter 5. The Structural Basis for Biological Signaling, Regulation, and Specificity in the Growth Hormone-Prolactin System of Hormones and ReceptorsI. Structural Basis for Receptor Homodimerization; II. Hormone Receptor Binding Sites; III. Hormone-Receptor Binding Energetics: The Binding ''Hot-Spot'' Concept; IV. Stereoselectivity of the Prolactin Receptor (hPRLR); V. Comparison of the hGH Site1 and Site2 Binding Energy Epitopes in the hGH-hGHR Ternary Complex; VI. Protein Engineering to Create New Properties; VII. Allosteric Effects, A Big Surprise
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VIII. Biological Implications of Transient Receptor DimerizationIX. Mechanism of ECD2 Binding, the Regulation Step in Biological Signaling; X. Future Directions; References; Chapter 6. Structural Analysis of IL-10 and Type I Interferon Family Members and Their Complexes with Receptor; I. Introduction; II. Structures of the HCIIs; III. Structures of the Class 2 Homology Region (C2HR); IV. Structure of the High-Affinity HCII/C2HR Interfaces; V. Concluding Remarks; References; Chapter 7. Assembly of Post-Receptor Singnaling Complexes for the Tumor Necrosis Factor Receptor Superfamily
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I. Introduction
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English
Weitere Ausg.:
ISBN 0-12-034268-5
Sprache:
Englisch
