UID:
almafu_9960074112002883
Umfang:
1 online resource (615 p.)
ISBN:
9780128004388
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012800438X
Inhalt:
Kidney Development, Disease, Repair and Regeneration focuses on the molecular and cellular basis of kidney development, exploring the origins of kidney lineages, the development of kidney tissue subcompartments, as well as the genetic and environmental regulation of kidney development. Special coverage is given to kidney stem cells and possible steps towards kidney repair and regeneration. Emphasis is placed on the fetal origins of postnatal renal disease and our current understanding of the molecular basis of damage and repair. Biomedical researchers across experimental nephrology and develo
Anmerkung:
Description based upon print version of record.
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Front Cover; Kidney Development, Disease, Repair and Regeneration; Copyright; Contents; Contributors; Foreword; Acknowledgments; SECTION - I; DEVELOPMENT; Chapter 1 - Zebrafish Renal Development and Regeneration; OVERVIEW; THE ZEBRAFISH PRONEPHROS AS A MODEL OF NEPHRON DEVELOPMENT AND INJURY; DEVELOPMENT AND REPAIR OF THE ZEBRAFISH MESONEPHROS; CONCLUSIONS; References; Chapter 2 - Early Specification and Patterning of the Intermediate Mesoderm: Genetics and Epigenetics; INTRODUCTION; EARLY DEVELOPMENT OF THE KIDNEY; EPIGENETIC REGULATION DURING KIDNEY DEVELOPMENT
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ROLE OF EPIGENETICS IN THE ADULT KIDNEYCONCLUSIONS; References; Chapter 3 - The Human Kidney: Parallels in Structure, Spatial Development, and Timing of Nephrogenesis; INTRODUCTION; ANATOMIC STRUCTURE OF THE MATURE HUMAN KIDNEY; ANATOMIC DEVELOPMENT OF THE KIDNEY; OTHER MAMMALIAN SPECIES: HOW THEY DIFFER; NEPHRON ENDOWMENT; CONCLUSION; References; Chapter 4 - RET Signaling in Ureteric Bud Formation and Branching; SHORT INTRODUCTION TO URETERIC BUD FORMATION AND BRANCHING; THE ROLE OF GDNF/GFRΑ1/RET SIGNALING IN MOUSE KIDNEY DEVELOPMENT
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MUTATIONS IN RET, GFRA1, AND GDNF IN HUMAN CONGENITAL KIDNEY DEFECTSREGULATION OF RET AND GDNF GENE EXPRESSION; SIGNALING PATHWAYS DOWNSTREAM OF RET; EFFECTS OF POINT MUTATIONS THAT REMOVE RET TYROSINE RESIDUES INVOLVED IN SIGNAL TRANSDUCTION; GENES THAT ACT DOWNSTREAM OF GDNF/GFRΑ1/RET SIGNALING; COOPERATION BETWEEN GDNF AND FGF10 SIGNALING IN UB OUTGROWTH AND BRANCHING; DOES GDNF/RET SIGNALING SPECIFY THE NORMAL PATTERN OF UB BRANCHING?; CELLULAR MECHANISMS OF BRANCHING MORPHOGENESIS AND THE ROLE OF RET SIGNALING; Acknowledgments; References
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Chapter 5 - Quantification of Developmental Branching MorphogenesisGENERAL INTRODUCTION; STEREOTYPY IN RENAL BRANCHING; CHALLENGES IN TRANSLATING RENAL BRANCHING KNOWLEDGE; References; Chapter 6 - Transcriptional Regulation of the Nephrogenic Mesenchyme and Its Progeny; INTRODUCTION; COUNTERACTION AND COOPERATION BETWEEN SIX2 AND WNT/Β-CATENIN SIGNALING IN REGULATION OF NEPHRON PROGENITORS; IDENTIFICATION OF DIRECT TRANSCRIPTIONAL TARGETS OF SIX2 AND Β-CATENIN IN NEPHRON PROGENITORS; COOPERATION BETWEEN SIX2 AND OSR1 IN THE REPRESSION OF WNT4; SALL1 AND WT1 IN NEPHRON PROGENITOR PROGRAMS
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MAINTENANCE OF NEPHRON PROGENITORSGENE REGULATORY NETWORKS ESTABLISHED BY TRANSIENT ACTIVATION OF WNT/Β-CATENIN SIGNALING; CLOSING REMARKS; Acknowledgments; References; Chapter 7 - The Role of Growth Factors in Balancing Cap Mesenchyme Survival and Differentiation; THE CAP MESENCHYME; GROWTH FACTOR SIGNALING IN CAP MESENCHYME DIFFERENTIATION; FIBROBLAST GROWTH FACTOR SIGNALING; WNT SIGNALING; BONE MORPHOGENETIC PROTEIN SIGNALING; INTERSECTIONS BETWEEN FGF, WNT, AND BMP PATHWAYS; FUTURE PERSPECTIVES; Acknowledgments; References; Chapter 8 - Notch Signaling in Nephron Segmentation; INTRODUCTION
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SIGNAL TRANSDUCTION OF NOTCH SIGNALING
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English
Weitere Ausg.:
ISBN 9780128001028
Weitere Ausg.:
ISBN 012800102X
Sprache:
Englisch
