Kooperativer Bibliotheksverbund

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Umfang: 1 online resource (354 pages) : , color illustrations

Ausgabe: First edition.

ISBN: 9780128031100 , 0128031107 , 9780128031094 , 0128031093

Anmerkung: Includes index. , Front Cover -- Viruses -- Copyright Page -- Contents -- About the Author -- Preface -- Acknowledgments -- 1 Introduction to Animal Viruses -- What Is a Virus? -- Diversity in the World of Viruses -- Are Viruses Alive? -- Basic Steps in the Virus Replication-Cycle -- Growing Viruses -- Categorizing Viruses (Taxonomy) -- Outcomes of Viral Infection -- Introduction to Viral Pathogenesis -- Introduction to Virus Transmission -- 2 Virus Structure -- Anatomy of a Virus -- Capsid Structure and Function -- Capsids Are Built From Many Copies of One or a Few Types of Protein -- Simple Icosahedral Capsids -- Larger Icosahedral Capsids -- Polyomavirus and Papillomavirus Capsids -- Adenovirus Capsids -- Reoviruses -- Herpesvirus Capsids -- Poxvirus Structure -- Viral Envelopes -- Glycosylation -- Other Membrane Proteins -- Matrix Proteins -- Nucleocapsid Structure -- 3 Virus Interactions With the Cell -- Virus Interactions with the Cell -- The Extracellular Space -- The Plasma Membrane -- Attachment Occurs at the Plasma Membrane -- Virus Penetration and Uncoating at the Plasma Membrane -- Virus Penetration and Uncoating From Membrane Bound Vesicles -- Membrane Fusion -- Uncoating the Genome -- Cytoskeleton -- Movement Through the Cell, Interactions With the Cytoskeleton -- Virus Assembly -- Virion Release -- Virion Maturation -- Amplification of Viral Proteins and Nucleic Acids in the Context of the Infected Cell -- A Short Review of Transcription in the Eukaryotic Host Cell -- Transcription of Viral mRNAs -- A Short Review of Translation in the Eukaryotic Host Cell -- Translation of Viral Proteins -- Synthesis of Viral Genomes -- 4 Methods to Study Viruses -- Growing Viruses -- Generating Cell Cultures -- Purifying Viruses -- Visualizing Viruses -- Optical Microscopy -- Light Microscopes -- Fluorescence Microscopy -- Electron Microscopy -- Counting Viruses. , Infectivity Assays -- Chemical/Physical Methods of Virus Quantitation -- Hemagglutination Assay -- Serologic Techniques -- Hemagglutination Inhibition Assay -- Virus Neutralization Assay -- Enzyme-Linked Immunosorbent Assays -- Cell-Based Fluorescent Antibody Assays -- Western Blots -- Immunohistochemistry -- Detecting Viral Nucleic Acids -- Polymerase Chain Reaction -- High Throughput Sequencing -- Basic Principles of Diagnostic Virology -- References -- 5 Virus Transmission and Epidemiology -- Methods to Count Viral Infections and Disease -- Infection Versus Disease -- Developing Models of Virus Transmission -- Incubation, Latent, and Infectious Periods -- Virus Transmission -- 6 Immunity and Resistance to Viruses -- Innate Immunity -- Toll-Like Receptors -- Retinoic Acid-Inducible Gene-Like Receptors -- NLRs Are Receptors With NOD-Like Domains -- Inflammasomes -- Proinflammatory Molecules -- Interferons -- Type I IFNs -- Type II IFN -- Type III IFNs -- IFNs Bind to Receptors and Signal Through Janus Kinase Signal Transducers and Activators of Transcription Pathways -- IFN-Stimulated Genes and the Antiviral State -- Protein Kinase RNA-Activated Pathway -- 2′-5′ Oligo A Synthase Pathway -- Other Interferon Stimulated Genes -- Intrinsic Immunity -- Restriction Factors -- Autophagy -- Natural Killer Cell Responses to Viral Infection -- Specific Immunity -- Antibody Responses -- Cell-Mediated Responses -- Antigen Presentation -- Viruses Fight Back -- Antigenic Variation -- Suppression of Antigen Presentation -- Suppression of IFN Responses -- Suppression or Coopting of Apoptosis and Autophagy -- Immunosuppression -- Poxviruses Encode Molecules That Mimic Cytokines, IFNs, and Their Receptors -- Hiding From the Immune System -- 7 Viral Vaccines -- Classical versus Engineered Vaccines -- Vaccines Provide a Source of Antigens. , Replicating versus Inactivated Vaccines -- Killed, Inactivated, and Subunit Vaccines -- Viral Vaccines that contain Infectious Agents -- Antigen Recognition -- Correlates of Protection -- Vaccine Development -- A Final Word about Safety -- 8 Virus Evolution and Genetics -- Virus Evolution -- Virus Genetics -- Recombination -- Genotypes and Phenotypes -- Nonessential Genes -- Forward and Reverse Genetics -- Reverse Genetics of Positive-Strand RNA Viruses -- Reverse Genetics of Negative-Strand RNA Viruses -- Reverse Genetics of Retroviruses -- Reverse Genetics of DNA Viruses -- 9 Viral Pathogenesis -- Natural Barriers to Infection -- Primary Replication -- Movement to Secondary Replication Sites -- Genesis of Disease -- Immunopathogenesis -- Virulence -- Approaches to Study Viral Pathogenesis -- 10 Introduction to RNA Viruses -- Definition and Basic Properties of RNA Viruses -- Subgroups of RNA Viruses -- Positive Strand RNA Viruses -- Negative Sense and Ambisense RNA Viruses -- dsRNA Viruses -- Structural Features of RNA Virus Genomes -- Priming Viral RNA Synthesis -- Mechanisms to Generate Capped mRNAs -- Mechanisms to Generate Polyadenylated mRNAs -- Mechanisms to Regulate Synthesis of Genomes and Transcripts -- RNA Viruses and Quasispecies -- References -- 11 Family Picornaviridae -- Genome Organization -- Virion Structure -- Picornavirus Replication (Poliovirus Model) -- Binding and Penetration -- Translation -- Genome Replication -- Assembly -- Maturation -- Picornaviruses and Disease -- Genus Enterovirus -- Genus Hepatovirus -- Genus Apthovirus: Foot and Mouth Disease Virus -- 12 Family Caliciviridae -- Genome Organization -- Virion Structure -- General Replication Cycle -- Attachment/Penetration -- Genome Replication -- Translation -- Assembly/Release -- Diseases -- Acute Gasterointestinal Disease -- Feline Calicivirus -- Rabbit Calicivirus. , 13 Family Hepeviridae -- Genome Organization -- Virion Morphology -- General Replication Cycle of HEV -- Disease -- 14 Family Astroviridae -- Genome Organization -- Virion Morphology -- Diseases Caused by Astroviruses -- References -- 15 Family Flaviviridae -- Genome Structure/Organization -- Virion Structure -- General Overview of Replication -- Protein Products -- Diseases -- Genus Hepacivirus: Hepatitis C Virus -- Genus Flavivirus -- Yellow Fever Virus -- Dengue Fever Virus -- West Nile Virus -- Zika Virus: An Emerging Threat -- Genus Pestivirus -- References -- 16 Family Togaviridae -- Genome Structure -- Virion Structure -- Togavirus Replication -- Attachment and Penetration -- Translation -- Genome Replication -- Assembly and Release -- Transmission -- Alphaviruses Associated With Rash and Arthritis -- Chikungunya Virus -- Sindbis Virus -- Alphaviruses of Veterinary Importance -- Rubella Virus -- References -- 17 Family Coronaviridae -- Coronavirus Genome Organization -- Virion Structure -- Coronavirus Structural Proteins -- Coronavirus Replication Cycle -- Attachment -- Penetration -- Amplification -- RNA Synthesis -- Assembly and Release -- Diseases Caused by Coronaviruses -- Severe Acute Respiratory Syndrome -- Middle East Respiratory Syndrome -- Feline Coronavirus and Feline Infectious Peritonitis -- References -- 18 Family Arteriviridae -- Genome Organization -- Virion Structure -- Replication Cycle -- Diseases Caused by Arteriviruses -- Equine Viral Arteritis -- Porcine Reproductive and Respiratory Syndrome -- Simian Hemorrhagic Fever Virus and Related Viruses -- References -- 19 Family Rhabdoviridae -- Genome Organization -- Virus Structure -- Overview of Replication -- Attachment and Penetration -- Amplification -- The Switch from mRNA Synthesis to Genome Replication -- Assembly/Release -- Diseases -- Rabies and Rabies-Related Viruses. , Vesicular Stomatitis Virus -- Chandipura Virus -- Other Rhabdoviruses associated with Disease -- 20 Families Paramyxoviridae and Pneumoviridae -- Genome Structure/Organization -- Virion Structure -- Overview of Replication -- Attachment and Penetration -- Transcription -- Protein Synthesis -- Genome Replication -- Assembly, Release, and Maturation -- Diseases -- Measles -- Mumps -- Respiratory Tract Diseases -- Canine Distemper -- Henipaviruses -- Pneumoviruses -- 21 Family Filoviridae -- Genome Organization -- Virion Structure -- Overview of Replication -- Attachment/Penetration -- Transcription -- Translation -- Genome Replication -- Assembly -- Disease -- Entry Into Host -- Pathogenesis -- EBOV and MARV Antagonize Innate Immune Responses -- 22 Family Bornaviridae -- Genome Organization -- Virion Structure -- Overview of Replication -- Attachment and Penetration -- Transcription -- Protein Synthesis -- Genome Replication -- Assembly, Release, and Maturation -- Diseases -- Borna Disease -- Birds and Bornaviruses -- 23 Family Orthomyxoviridae -- Genome Structure/Organization -- Virion Structure -- Classification and Nomenclature of Orthomyxoviruses -- Overview of Replication -- Hemagglutinin -- Neuraminidase -- Matrix Protein (M1) -- M2 -- Nucleoprotein -- RNA Polymerase Complex -- Nuclear Export Protein -- Nonstructural Protein 1 -- Attachment/Penetration -- Transcription -- Translation -- Genome Replication -- Assembly, Budding, and Maturation -- Antigenic Drift and Antigenic Shift -- Disease -- Avian Influenza -- Antiviral Drugs -- Vaccines -- References -- 24 Family Bunyaviridae -- Genome Organization -- Virion Structure -- General Replication Strategy -- Attachment -- Penetration and Uncoating -- Amplification -- Assembly and Release -- Diseases -- La Crosse Virus -- Oropouche Virus -- Schmallenberg and Cache Valley Viruses. , Rift Valley Fever Virus.

Sprache: Englisch

Schlagwort(e): Electronic books.

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