UID:
almafu_9961125461802883
Umfang:
1 online resource (xi, 270 pages)
Inhalt:
This book reviews the brilliant progress made in the past three decades in clinical outcomes for osteosarcoma patients treated with a multidisciplinary approach, including limb-salvage surgery combined with neoadjuvant multidrug chemotherapy and aggressive management of pulmonary metastasis. Osteosarcoma was a miserable disease for adolescents and young adults until the early 1970s, with a survival rate that was less than 10-15% even after amputation for affected limbs because of the progression of pulmonary metastasis. With the development of neoadjuvant chemotherapy for osteosarcoma, including high-dose methotrexate, doxorubicin, cisplatin, and ifosfamide during the late 1970s and the 1980s, however, the prognosis has dramatically improved. Limb-salvage surgery for patients with extremity osteosarcoma is now a gold-standard surgical procedure for more than 90% of patients with localized disease. Additionally, aggressive pulmonary metastasectomy for patients with lung metastasis from osteosarcoma has contributed to improvement of their survival. More recently, carbon-ion radiotherapy has also been introduced for patients with unresectable osteosarcoma of the trunk, as in the spine and pelvis. In this volume the author provides valuable descriptions of an important new treatment modality for a multidisciplinary approach for osteosarcoma patients.
Anmerkung:
Part I: Basic Research -- and Experimental -- Therapy.-Chapter 1 -- Genetics of -- Osteosarcoma.-Chapter -- 2 Basic Research for -- Osteosarcoma Lung -- Metastasis (LM8).- -- Chapter 3 -- Immunotherapy for -- Osteosarcoma.-Part II: -- Clinical Features.- -- Chapter 4 Outcome of -- Treatment for -- Osteosarcoma of the -- Extremities over the Last -- 20 Years: Report from 11 -- Referral Centers in -- Japan.-Chapter 5 -- Osteosarcoma in the -- Elderly: Clinical Features -- and Outcome.-Chapter 6 -- Prognostic Factors for -- Osteosarcoma Patients.- -- Part III: Chemotherapy.- -- Chapter 7 Neoadjuvant -- Chemotherapy -- Developed in Japan.- -- Chapter 8 Neoadjuvant -- Chemotherapy (OOS-A, -- B, C, D regimens).- -- Chapter 9 Caffeine- -- Potentiated -- Chemotherapy for -- Osteosarcoma.-Part IV: -- Surgery.-Chapter 10 -- Endoprosthetic -- Reconstruction for -- Extremity -- Osteosarcoma.-Chapter -- 11 Limb-Salvage Surgery -- and Reconstruction for -- Skeletally -- Immatur Childhood -- Osteosarcoma: -- Extendible -- Endoprostheses.- -- Chapter 12 Limb-Salvage -- Surgery for Pelvic -- Osteosarcoma -- Chapter 13 -- Management of -- Postoperative -- Infection after -- Limb Salvage -- Surgery in -- Osteosarcoma -- Patients. -- Part V: Surgery : -- Biological -- Reconstruction. -- Chapter 14 -- Biological -- Reconstruction -- for Extremity -- Osteosarcoma: -- Long Term -- Results and -- Current Concept -- of Intraoperative -- Extracorporeal -- Irradiated Bone -- Graft (IORBG) -- Chapter 15 -- Biological -- Reconstruction -- for Extremity -- Osteosarcoma: -- Pasteurized -- Autogenous -- Bone Graft -- Chapter 16 -- Biological -- Reconstruction -- for Extremity -- Osteosarcoma: -- Liquid Nitrogen -- Treated Tumor- -- Bearing Bone -- Graft -- Chapter 17 -- Biological -- Reconstruction -- for Extremity -- Osteosarcoma -- Distraction -- Osteogenesis -- Technique. -- Chapter 18 Limb-Saving -- Surgery -- Using In Situ -- Preparation (ISP) -- Method -- Part VI: -- Unresectable / -- Metastatic -- Disease. -- Chapter 19 -- Carbon Ion -- Radiotherapy for -- Un resectable -- Osteosarcoma of -- the Trunk -- Chapter 20 -- Treatment of -- Osteosarcoma -- Patients with -- Pulmonary -- Metastasis -- Chapter 21 Long-Term -- Outcomes -- and Quality of -- Life (QOL) in -- Survivors of -- Pediatric and -- Adolescent -- Osteosarcoma.
Weitere Ausg.:
ISBN 9781839680168
Weitere Ausg.:
ISBN 1839680164
Sprache:
Englisch
