Umfang:
1 Online-Ressource.
Ausgabe:
Second edition
ISBN:
978-1-118-14029-1
,
1-118-14029-X
,
978-1-119-49781-3
,
1-119-49781-7
Inhalt:
Machine generated contents note:SECTION IPRINCIPLES AND METHODS --1.Modeling In The Pharmaceutical Industry --1.1.Introduction --1.2.Modeling Approaches --1.3.Steps Needed to Maximize Effective Integration of Models into R&D Workflow --1.4.Scope of the Book --Keywords --References --2.Physiologically-Based Modeling --2.1.Introduction --2.2.Examples of Physiological Modeling --2.3.Need for Physiological Models in the Pharmaceutical Industry --2.4.Organs as Compartments --2.5.Bottom-Up vs.
Inhalt:
Top-Down Modeling in Pharmacokinetics --References --3.Review Of Pharmacokinetic Principles --3.1.Introduction --3.2.Routes of Administration --3.3.Drug Disposition --3.3.1.Absorption --3.3.2.Plasma Protein Binding, Blood-Plasma Ratio --3.3.3.Distribution, Elimination, Half-Life, and Clearance --3.3.4.Role of Transporters in ADME --3.4.Linear and Nonlinear Pharmacokinetics --3.5.Steady-State Pharmacokinetics --3.6.Dose Estimations --3.7.Successful PK Optimization in Drug Discovery --Keywords --References --4.Physiological Model For Absorption --4.1.Introduction --4.2.Drug Absorption and Gut Bioavailability --4.2.1.Solubility and Dissolution Rate --4.2.2.Permeability: Transcelluar, Paracellular, and Carrier-Mediated Pathways --4.2.3.Barriers to Membrane Transport --
Inhalt:
Luminal Degradation, Efflux, and Gut Metabolism --4.3.Factors Affecting Drug Absorption and Gut Bioavailability --4.3.1.Physiological Factors Affecting Oral Drug Absorption and Species Differences in Physiology --4.3.2.Compound-Dependent Factors --4.3.3.Formulation-Dependent Factors --4.4.In Silico Predictions of Passive Permeability and Solubility --4.4.1.In Silico Models for Permeability --4.4.2.In Silico Models for Solubility --4.5.Measurement of Permeability, Solubility, Luminal Stability, Efflux, and Intestinal Metabolism --4.5.1.In Vitro,
Anmerkung:
Includes bibliographical references and index
Weitere Ausg.:
Erscheint auch als Druck-Ausgabe ISBN 9781119497684
Sprache:
Englisch
Fachgebiete:
Chemie/Pharmazie
Schlagwort(e):
Pharmakokinetik
;
Mathematische Modellierung
;
Electronic books
;
Electronic books
DOI:
10.1002/9781119497813
URL:
Volltext
(URL des Erstveröffentlichers)
URL:
Volltext
(URL des Erstveröffentlichers)
