UID:
almahu_9947420909902882
Format:
1 online resource (779 p.)
Edition:
3rd ed.
ISBN:
1-4377-1099-9
Content:
Successfully fighting cancer starts with understanding how it begins. This thoroughly revised 3rd Edition explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of cancer. A team of leading experts thoroughly explain the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Incorporating cutting-edge advances and the newest research, the book provides thorough descriptions of everything from molecular abnormalities in common cancers to new
Note:
Description based upon print version of record.
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Front Cover; The Molecular Basis of Cancer; Copyright Page; List of Contributing Authors; Preface; Contents; Part I: Carcinogenesis and Cancer Genetics; Chapter 1. Cancer: A Genetic Disorder; The Discovery of Cellular Oncogenes; Multistep Tumorigenesis; The Discovery of Tumor Suppressor Genes; Guardians of the Genome; Epigenetic Mechanisms Leading to Loss of Gene Function; Immortalized Proliferation; Nongenetic Mechanisms Accelerating Multistep Tumor Progression; Invasive and Metastatic Behaviors; Other Phenotypes of Neoplasia; References; Chapter 2. Oncogenes and Signal Transduction
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Signaling: An OverviewOncogenes; Signal Transduction by Protein Tyrosine Kinase Receptors; Signaling Pathways of Tyrosine Kinase Receptors; Oncogenes and Survival Signaling; Cytokine Receptor Signaling; Neurotransmitters; Wnt Signaling; Implications for Cancer Therapy; References; Chapter 3. Tumor Suppressor Genes; The Concept of Tumor Suppressor Genes; The Tumor Suppressor Genes; The p53-Rb Pathway Interconnections; The Interconnections of the p53 and the IGF-1-mTOR Pathways; Conclusion; References; Chapter 4. DNA Repair Pathways and Human Cancer; The Spectrum of DNA Damage; DNA Repair
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The Systematic Study of DNA RepairDNA Repair and the DNA Damage Response; Inherited Chromosome Instability Syndromes as Models for DNA Repair Defects; Somatic Disruption of DNA Repair Pathways by Methylation and Gene Silencing; Prognostic and Predictive DNA Repair Biomarkers in Cancer Treatment; Development of new DNA Repair Biomarkers; Multiple Mechanisms of Cisplatin Resistance; Conclusion; References; Chapter 5. Epigenetics and Cancer; The Molecular Basis for Epigenetic Control of Gene Expression; Abnormalities of DNA Methylation and Chromatin Organization in Cancer: the Cancer "Epigenome"
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Relationships of Epigenetic Changes in General, and Aberrant Gene Silencing in Particular, to the Progression of CancerTranslational Implications of Epigenetic Changes in Cancer; References; Chapter 6. Infectious Agents and Cancer; Overview of Cancer and Infectious Agents; Viruses and Cancer; Bacteria and Cancer; Parasites and Cancer; Perspectives; References; Chapter 7. Environmental Carcinogenesis; Introduction to Cancer and the Environment; Causes of Cancer; Classes and Types of Carcinogens; Mechanisms of Chemical Carcinogenesis; Ecogenetics and Cancer Risk; Cancer Prevention
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Summary and ConclusionsReferences; Chapter 8. Animal Models Flies, Fish, and Yeast; Why Use a Simple Model Organism?; Genetic Conservation and Synteny; Forward Genetics, Reverse Genetics, and Transgenesis; Drug Screens; Conditional Models; Yeast; Flies; Fish; Conclusion; References; Chapter 9. Genetic Mouse Models of Cancer; Basis for Mouse Models of Cancer; Mouse Models of Cancer; Techniques to Modify the Mouse Genome; Applications of Mouse Models to Cancer Biology; Future Directions of Cancer Models; Conclusions; References; Part II: Cancer Biology; Chapter 10. Cancer Stem Cells
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Not All Cancer Cells are Created Equal
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English
Additional Edition:
ISBN 1-4160-3703-9
Language:
English
