UID:
almahu_9948022754202882
Umfang:
1 online resource (1201 p.)
Ausgabe:
4th ed.
ISBN:
0-12-800589-0
,
0-12-800188-7
Inhalt:
The Comprehensive Sourcebook of Bacterial Protein Toxins 4th Edition, contains chapters written by internationally known and well-respected specialists. This book contains chapters devoted to individual toxins, as well as chapters that consider the different applications of these toxins. Considerable progress has been made in understanding the structure, function, interaction and trafficking into cells, as well as mechanism of action of toxins. Bacterial toxins are involved in the pathogenesis of many bacteria, some of which are responsible for severe diseases in human and animals, but can al
Anmerkung:
Description based upon print version of record.
,
Front Cover; The Comprehensive Sourcebook of Bacterial Protein Toxins; Copyright Page; Contents; List of Contributors; Introduction to the Fourth Edition; In memory of J. E. Alouf (1929-2014); I. Basic Genomic and Physiological Aspects of Bacterial Protein Toxins; 1 Evolutionary aspects of toxin-producing bacteria; Introduction; Molecular ecology of toxin-producing bacteria; Pathogenicity islands, horizontal gene transfer, and the prevalence of toxins; Toxins encoded by plasmids, bacteriophages, and other pathogenicity islands; PAI-encoded toxins delivered by specialized secretion systems
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Molecular evolution of toxins through genetic exchangeGenetic exchange and toxin evolution; Toxin evolution and transmission in the host; Toxin evolution and transmission in the soil environment; Toxin evolution and transmission in aquatic environments; Toxin evolution and transmission in the phyllosphere; Toxin evolution in the guts of insects and other vectors; Toxin evolution in biofilms and regulation by quorum sensing; Vaccines and toxin evolution; Modular recombination of bacterial toxins; Conclusion; References
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2 Mobile genetic elements and pathogenicity islands encoding bacterial toxinsIntroduction: The genome structure of prokaryotes; Protein toxins encoded by mobile genetic elements; Protein toxins encoded by plasmids; Gram-negative bacteria; Gram-positive bacteria; Protein toxins encoded by bacteriophages; Gram-negative bacteria; Gram-positive bacteria; Protein toxin genes and other mobile genetic elements; Toxins encoded by PAIs; PAIs; PAI-encoded toxins; Enterobacteria; Other Gram-negative bacteria; The bacterial T6SS; Gram-positive bacteria; Instability of PAIs; Conclusion
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Evolution of new pathogenic variants caused by PAIs and mobile genetic elementsHGT and the evolution of toxin families; Acknowledgments; References; 3 News and views on protein secretion systems; Introduction; Most historical secretion types; Type I secretion system; Type II secretion system; Type III secretion system; Type IV secretion system: a protein and DNA transport machine; Type V secretion system: free or surface-bound?; Type VI secretion system: weapon for bacterial warfare; How far can we go with secretion types?; Type VII secretion system
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Extracellular appendages and secretion typesThe type IX secretion system; What about other secretion concepts?; Bacteriocins, colicins, pyocins, contact-dependent inhibition; Cell surface lipoproteins; OM Vesicles; What about Gram-positive bacteria, then?; Closing remarks; References; II. Intracellularly Alive Bacterial Protein Toxins; 4 Diphtheria toxin; Introduction; Diphtheria toxin: from pathology to crystal structure; Symptoms, treatment, prophylaxis, and epidemiology of diphtheria; History of DT research; Regulation of DT production; The structure of DT; The mechanism of action of DT
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The main steps of cell intoxication
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English
Sprache:
Englisch
