Kooperativer Bibliotheksverbund

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Format: 1 online resource (727 p.)

Edition: 3rd ed.

ISBN: 0-323-33946-8

Content: The third edition of Pediatric Allergy continues this title's steadfast tradition of providing comprehensive, authoritative guidance on the day-to-day diagnosis and management of pediatric allergic and immunologic diseases. You'll have the most up-to-date research at hand thanks to an easily accessible full-color format that highlights a host of new chapters, extensive updates, and clinically focused coverage. Whether you're a student, resident, pediatrician or allergist, you'll appreciate this user-friendly and versatile source for providing optimal care! Includes diagnostic tests available

Note: Description based upon print version of record. , Front cover -- Half title page -- Dedication -- Pediatric Allergy: Principles and Practice -- Copyright page -- Table of Contents -- List of Contributors -- Preface -- A General Concepts -- 1 Epidemiology of Allergic Diseases -- Key Points -- Introduction -- Prevalence of Childhood Asthma and Allergies -- Western versus Developing Countries -- The East-West Gradient across Europe -- Differences between Rural and Urban Populations -- Inner City Areas of the USA -- Time Trends in the Prevalence of Allergic Diseases -- Environmental Risk Factors for Allergic Diseases -- Air Pollution -- Environmental Tobacco Smoke -- Water Hardness and Dampness -- Nutrition -- Allergen Exposure -- Family Size, Infections and Hygiene -- Gene-Environment Interactions -- Conclusions -- Key References -- References -- 2 Natural History of Allergic Diseases and Asthma -- Key Points -- Allergic March of Childhood -- Early Immune Development Underlying Allergies -- Total Serum IgE Levels -- Allergen-Specific IgE -- Allergen-Specific Th2 Lymphocytes, and Their Regulation by Th1 and Treg Lymphocytes -- Childhood Asthma -- Early Childhood: Transient vs Persistent Asthma -- Asthma from Childhood to Adulthood -- Risk Factors for Persistent Asthma -- Allergy -- Gender -- Parental History of Asthma -- Lower Respiratory Tract Infections -- Environmental Tobacco Smoke Exposure -- Asthma- and Allergy-Protective Influences -- Breastfeeding -- Microbial Exposures -- Pet Ownership -- Vitamin D -- Childhood Asthma Phenotypes -- Atopic Dermatitis -- Allergic Rhinitis -- Food Allergy -- Anaphylaxis -- Gene-Environment Interactions -- Prevention Studies -- Avoidance versus Early Introduction of Allergenic Foods -- Inhalant Allergen Elimination/Reduction -- Breastfeeding -- Environmental Tobacco Smoke Elimination/Reduction -- Pharmacologic Intervention -- Antihistamines. , Conventional 'Controller' Pharmacotherapy for Asthma -- Allergen-Specific Immunotherapy -- Probiotics -- Conclusions -- Acknowledgment -- Key References -- References -- 3 The Genetics of Allergic Disease and Asthma -- Key Points -- Why Undertake Genetic Studies of Allergic Disease? -- Approaches to Genetic Studies of Complex Genetic Diseases -- What is a Complex Genetic Disease? -- How to Identify Genes Underlying Complex Disease -- Inheritance -- Phenotype -- Population -- Genetic Markers -- Approaches to Analysis -- Identify Gene -- Allergy and Asthma as Complex Genetic Diseases -- Phenotypes for Allergy and Allergic Disease: What Should We Measure? -- The Heritability of Atopic Disease: Are Atopy and Atopic Disease Heritable Conditions? -- Molecular Regulation of Atopy and Atopic Disease, I: Susceptibility Genes -- Positional Cloning by Genome-Wide Screens -- Genes Identified by Genome-Wide Association Studies -- Candidate Gene/Gene Region Studies -- An Example of a Candidate Gene: Interleukin-13 -- An Example of a Candidate Gene: Interleukin-33 -- Analysis of Clinically Defined Subgroups -- Filaggrin -- Molecular Regulation of Atopy and Atopic Disease, II: Disease-Modifying Genes -- Genetic Influences on Disease Severity -- Genetic Regulation of Response to Therapy: Pharmacogenetics -- Epigenetics and Allergic Disease -- Conclusions -- Key References -- References -- 4 Regulation and Biology of Immunoglobulin E -- Key Points -- Components of the Immune Response -- Immunoglobulin E Protein Structure and Gene Organization -- Regulation of IgE Isotype Switching -- ε-Germline Transcription Precedes Isotype Switch Recombination -- Regulation of Germline Transcription, The Iε Promoter -- Cytokines IL-4 and IL-13 Activate STAT-6 -- CD40/CD154 Provides Second Signal for Isotype Switch Recombination. , Alternative Second Signals for Isotype Switch Recombination -- Cytokine-Stimulated Germline Transcripts and CD40-Induced AID Collaborate to Execute Switch Recombination -- Regulation of Allergen-Specific T Cell Responses -- Th2 Helper T Cell Development -- Genetic Influences on Th2 Development -- Antigen-Presenting Cell Function in Th Differentiation -- Microbial Products and Dendritic Cell Phenotype -- Non-T Cell Sources of IL-4: Mast Cells, Basophils, NKT Cells and NK Cells -- Sites of IgE Class Switch Recombination and Mechanisms of IgE Memory -- IgE Receptors -- FcεRI Structure -- CD23 Expression and Structure -- Principles of IgE-Mediated Disease Mechanisms -- Mast Cell Activation and Homeostasis -- FcεRI Signaling -- Antigen-Independent IgE Signaling via FcεRI and IgE Effects on Mast Cell Homeostasis -- Regulation of IgE Receptors by IgE -- CD23 Function: Antigen Capture -- CD23 Function: IgE Regulation -- Conclusions -- Key References -- References -- 5 Inflammatory and Effector Cells/Cell Migration -- Key Points -- Introduction -- Myelocytes -- Eosinophils -- Mast Cells -- Basophils -- Macrophages -- Neutrophils -- Dendritic Cells -- Lymphocytes -- T Cells -- B Cells -- Natural Killer Cells -- Natural Killer T Cells -- γ/δ T Cells -- Innate Lymphoid Cells -- Leukocyte Recruitment -- Chemokine and Chemokine Receptor Families -- Chemokine Receptor Signal Transduction -- Regulation of Chemokine and Chemokine Receptor Expression -- Cellular Receptor Expression -- Chemokine Regulation of Leukocyte Effector Function -- Chemoattraction -- Cellular Activation -- Hematopoiesis -- Modulation of T Cell Immune Responses -- Conclusion -- Key References -- References -- 6 The Developing Immune System and Allergy -- Key Points -- Immune Function during Fetal Life -- Resistance to Infection during Infancy -- Surface Phenotype of T Cells in Early Life. , Functional Phenotype of T Cells during Infancy and Early Childhood -- Innate Immunity in Neonates -- B Cell Function in Early Life -- Antigen-Presenting Cell Populations -- Granulocyte Populations -- Postnatal Maturation of Immune Functions and Allergic Sensitization -- Conclusions -- Key References -- References -- B Immunologic Diseases -- 7 Approach to the Child with Recurrent Infections Including Molecular Diagnostics -- Key Points -- Definition of Recurrent Infections -- The Clinical Presentation of Underlying Disorders -- Allergy -- Immunodeficiency -- Infection -- Autoimmune/Chronic Inflammatory Disease -- Syndrome Complexes -- Cystic Fibrosis -- Abnormalities of Airway Anatomy and Physiology -- Disorders of Ciliary Structure and Function -- Secondary Immunodeficiency -- Laboratory Tests for Underlying Disorders -- Immunodeficiency -- Examination of the Peripheral Blood Smear -- Evaluation of Humoral Immunity -- Evaluation of Cell-Mediated Immunity -- Evaluation of the Complement System -- Evaluation of Phagocytic Cells -- Evaluation of Cilia -- Cystic Fibrosis -- Evaluation for Human Immunodeficiency Virus and Other Immunosuppressive Virus Infections -- Molecular Diagnostics -- Conclusions -- Helpful Website -- Key References -- References -- 8 Antibody Deficiency -- Key Points -- X-Linked Agammaglobulinemia -- Autosomal Agammaglobulinemia -- Common Variable Immunodeficiency -- IgA Deficiency -- IgG Subclass Deficiency -- Specific Antibody Deficiency With Normal Immunoglobulins -- Transient Hypogammaglobulinemia of Infancy -- Hyper-IgM Syndromes -- Differential Diagnosis -- Evaluation -- Treatment -- Conclusions -- Helpful Websites -- Key References -- References -- 9 T Cell Immunodeficiencies -- Key Points -- Severe Combined Immunodeficiency -- Etiology -- SCID Caused by Adenosine Deaminase Deficiency -- Reticular Dysgenesis. , X-Linked Severe Combined Immunodeficiency (SCIDX1, γc Deficiency) -- JAK-3 Deficiency -- IL-7Rα Deficiency -- T− B− SCID Caused by Defective VDJ Recombination -- CD3/TCR Deficiencies -- CD45 Deficiency -- Other Combined Immunodeficiencies -- Omenn Syndrome and Other Conditions Associated with Hypomorphic RAG Mutations -- Nucleoside Phosphorylase Deficiency -- TCRα Constant Chain (TRAC) Gene Defect -- Defects of TCR Signaling -- DOCK8 Deficiency -- Human 'Nude' Phenotype (FOXN1 Defect) -- Coronin-1A Deficiency -- Major Histocompatibility Complex (MHC) Class II Deficiency -- MHC Class I Deficiency -- Deficiency of Calcium-Release Activated Channels (CRAC) and of Magnesium Flux -- Immunodeficiency with Immune Dysregulation due to Impaired IL-2 Signaling -- IL-21 Receptor (IL-21R) Deficiency -- CD27 Deficiency -- T cell Defects with Impaired NF-κB Activation -- Immunodeficiency due to Activating PI3K-δ Mutations -- Cytidine 5′ Triphosphate Synthase 1 (CTPS1) Deficiency -- Differential Diagnosis of SCID and Other Combined Immunodeficiencies -- Evaluation and Management -- Treatment -- DiGeorge Syndrome -- Syndromes with Significant T Cell Deficiency -- Immuno-Osseous Syndromes -- Cartilage Hair Hypoplasia -- Schimke Syndrome -- Combined Immunodeficiency with Multiple Intestinal Atresias -- Immunodeficiency Syndromes with Defective DNA Repair -- Wiskott-Aldrich Syndrome -- Hyper-IgM Syndromes due to CD40 Ligand (CD40L) or to CD40 Deficiency -- Conclusions -- Helpful Websites -- Key References -- References -- 10 Complement Deficiencies -- Key Points -- Pathophysiology of Increased Susceptibility to Infection -- Pathophysiology of Systemic Autoimmune Disorders -- Pathophysiology of Atypical Hemolytic Uremic Syndrome (HUS) -- Inherited Complement Deficiencies -- C1q Deficiency -- C1r/C1s Deficiency -- C4 Deficiency -- C2 Deficiency -- C3 Deficiency. , C5 Deficiency. , English

Additional Edition: ISBN 0-323-29875-3

Language: English