Kooperativer Bibliotheksverbund

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Format: 1 online resource (640 pages).

ISBN: 0-12-802615-4 , 0-12-802395-3

Series Statement: Handbook of Clinical Neurology ; Volume 145

Note: Front Cover -- Neuropathology -- Copyright -- Handbook of Clinical Neurology 3rd Series -- Foreword -- Preface -- Contributors -- Contents -- Section I: Pathology of the central nervous system -- Chapter 1: Techniques in neuropathology -- Introduction -- Gross examination -- Neuroanatomy -- Light microscopy -- Histologic techniques -- Immunohistochemistry -- Electron microscopy -- Molecular biology -- Epigenetics -- Summary -- References -- Chapter 2: Banking brain tissue for research -- Human tissue for research -- The origin of collections of human tissue and fluids -- Transformation of collections into biobanks -- Conclusion -- Acknowledgments -- Disclaimer -- References -- Chapter 3: Cellular reactions of the central nervous system -- Introduction -- Neurons -- Definition and markers -- Pathologic reactions -- Astrocytes -- Definition and markers -- Pathologic reactions -- Oligodendroctyes -- Definition and markers -- Pathologic reactions -- Microglia -- Definition and markers -- Pathologic reactions -- Ependymal cells -- Definition and markers -- Pathologic reactions -- Choroid plexus -- Definition and markers -- Pathologic reactions -- References -- Chapter 4: Raised intracranial pressure and brain edema -- Classification -- Cytotoxic edema -- Ionic edema (osmotic edema) -- Vasogenic edema -- High-altitude cerebral edema -- Interstitial edema -- Epidemiology -- Clinical phenotypes and imaging -- Traumatic brain injury -- Hemorrhagic stroke -- Ischemic stroke -- Tumors -- Infections -- Chronically increased ICP -- Imaging -- Neuropathology -- Macroscopy -- Microscopy -- Pathogenesis, experimental models, and biochemistry -- References -- Chapter 5: Cerebrospinal fluid circulation and hydrocephalus -- CSF circulation -- Classification -- Chronic hydrocephalus -- Epidemiology -- Hydrocephalus in children -- Chronic hydrocephalus. , Idiopathic intracranial hypertension -- Clinical phenotypes and imaging -- Idiopathic intracranial hypertension -- Chronic hydrocephalus - normal-pressure hydrocephalus -- Long-standing overt ventriculomegaly in adults -- Neuropathology -- Macroscopy -- Microscopy/immunohistochemistry -- Overview of the diagnostic approach -- Diagnostic criteria -- Pathogenesis, experimental models, and biochemistry -- Secondary hydrocephalus -- References -- Chapter 6: Developmental and perinatal brain diseases -- Brain development -- Macroscopic examination -- Corticogenesis -- Development of the cerebellum -- Development of the spinal cord -- CNS manifestations of chromosomal change -- Forebrain patterning defects -- Neural tube defects -- Midline patterning defects -- Holoprosencephaly -- Atelencephaly/aprosencephaly -- Agenesis of the corpus callosum -- Septo-optic dysplasia -- Disorders of brain size -- Microcephaly -- Megalencephaly and hemimegalencephaly -- Thanatophoric dysplasia -- Cell migration and specification disorders -- Lissencephaly, type I -- Genetics -- Lissencephaly, type II (cobblestone lissencephaly) -- Polymicrogyria -- Cerebral heterotopia -- Diffuse nodular heterotopia -- Nodular heterotopia -- Laminar heterotopia -- Leptomeningeal glioneuronal heterotopia -- Tuberous sclerosis -- Cerebellum, hindbrain, and spinal patterning defects -- Chiari malformations -- Dandy-Walker malformation -- Joubert syndrome -- Cerebellar heterotopias -- Rhombencephalosynapsis -- Olivary heterotopia -- Dysplasias of the dentate and olivary nuclei -- Dentato-olivary dysplasia with intractable seizures in infancy -- Moebius syndrome -- Abnormalities of the pyramidal tracts -- Pontine tegmental cap dysplasia -- Pontocerebellar hypoplasia -- Spinal cord lesions -- Hydrocephalus -- Secondary malformations and destructive pathologies -- Antenatal disruptive lesions. , Hemorrhagic lesions -- White-matter lesions in the perinatal period -- Gray-matter lesions -- Cerebral cortex -- Hippocampus -- Basal nuclei and thalamus -- Cerebellum -- Brainstem and spinal cord -- Vascular malformations -- Aneurysmal malformation of the vein of Galen -- Sturge-Weber syndrome -- Fowler syndrome: proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome -- Arachnoid cysts -- Infectious diseases -- References -- Chapter 7: Neuropathology of cerebrovascular diseases -- Epidemiology -- Anatomy of the cerebral blood vessels -- Pathophysiology: ischemia, hypoxia, and related conditions -- Necrosis, apoptosis, necroptosis, and delayed neuronal death -- Necrosis -- Apoptosis -- Necroptosis -- Delayed neuronal death -- Hypoxia -- General responses to hypoxia -- Hypobaric hypoxia -- Clinical symptoms -- Neuropathology -- Hypoxemia and anemic hypoxia -- Histotoxic hypoxia: sulfide, cyanide, and azide -- Clinical symptoms -- Neuropathology -- Carbon monoxide damage -- Clinical symptoms -- Neuropathology -- Clinical outcome in surviving cases -- Hyperoxic brain damage and decompression sickness -- Hyperoxic brain damage -- Clinical symptoms -- Decompression sickness -- Clinical symptoms -- Neuropathology -- Other causes -- Patterns of cell injury: selective cell and regional vulnerability -- Selective regional vulnerability -- Reperfusion injury -- Diseases of the vessels -- Atherosclerosis -- Hypertensive angiopathy -- Small-vessel (degenerative) disease: arteriolosclerosis, arteriolar hyalinosis, lipohyalinosis, and fibrinoid necrosis -- Inflammatory vascular diseases -- Giant-cell arteritis (temporal arteritis, Horton arteritis: GCA) -- Primary cerebral angiitis -- Takayasu arteritis -- Systemic vasculitis in autoimmune diseases -- Infectious vasculitis -- Drug-induced vasculitis -- Cerebral amyloid angiopathies (CAA). , Aβ-related angiitis -- CADASIL -- CARASIL -- Cerebrovascular occlusive diseases with retinal involvement -- Other diseases that can lead to cerebrovascular occlusion -- Fibromuscular dysplasia -- Sneddon syndrome -- Moyamoya syndrome -- Hodgkin lymphomas -- Fabry disease -- Clinical manifestations of diseases of the blood vessels -- Complementary methods in the study of diseases of blood vessels, including neuropathologic examination -- Angiography and MRI angiography -- Peripheral nerve biopsies -- Intracranial (and intraspinal) aneurysms and vascular malformations -- Saccular aneurysms -- Dolichoectasia and fusiform aneurysms -- Capillary telangiectasias -- Cavernous angiomas (cavernous hemangiomas, cerebral cavernous malformations) -- Arteriovenous malformations -- Venous malformations -- Aneurysms of the vein of Galen -- Fistulas -- Hematologic disorders -- Brain ischemic damage -- Focal cerebral ischemia -- Infarct progression -- Morphologic changes -- Hemorrhagic infarcts -- Brain edema associated with infarction -- Neuroimaging correlates -- The penumbra -- Clinical and pathologic correlations -- Global cerebral ischemia -- Morphologic changes -- Permanent global ischemia -- Clinical and pathologic correlates -- Venous thrombosis and infarction -- Clinical aspects -- Other brain lesions related to ischemia -- Lacunas and lacunar state -- Status cribrosus -- Dilatation of the perivascular spaces of the perforant arteries -- Granular atrophy of the cerebral cortex -- Hippocampal sclerosis -- Vascular leukoencephalopathy: Binswanger-type leukoencephalopathy -- Multi-infarct encephalopathy -- Clinical manifestations -- Neuroimaging -- Spontaneous intracranial bleeding -- Subarachnoid hemorrhages -- Morphologic changes -- Parenchymal hemorrhages -- Morphologic changes -- Clinical symptoms and diagnosis by neuroimaging. , Vascular cognitive impairment -- References -- Chapter 8: Neurotrauma -- Introduction -- Epidemiology -- Classification of traumatic brain injury -- Diffuse traumatic axonal injury and diffuse vascular injuries -- Histopathologic identification of TAI -- Hemorrhagic lesions associated with rotational injury -- Causes of diffuse TAI -- Contusions and intracranial hemorrhages -- Contusions -- Intracranial hemorrhages -- Extradural (epidural) hematoma -- Subdural hematomas -- Acute subdural hematoma -- Chronic subdural hematoma -- Subarachnoid hemorrhage -- Intracerebral hemorrhage -- Other vascular lesions -- Traumatic intraventricular hemorrhage -- Focal vascular injuries -- Spinal cord trauma -- Long-term consequences of TBI -- Concussion -- Long-term cognitive problems -- Repetitive head injury and chronic traumatic encephalopathy -- Single episode of TBI -- Penetrating head injuries -- Blast injuries -- References -- Chapter 9: Neurometabolic and neurodegenerative diseases in children -- Introduction -- Lysosomal diseases -- Nonvacuolar lysosomal diseases -- Sphingolipidoses -- Definition -- Classification -- Clinical phenotypes -- Neuropathology -- Macroscopy -- Microscopy -- Diagnostic approach -- Pathogenesis -- Neuronal ceroid-lipofuscinoses -- Definition -- Epidemiology -- Classification -- Clinical phenotypes -- Neuropathology -- Macroscopy -- Microscopy -- Diagnostic approach -- Diagnostic criteria -- Pathogenesis -- Vacuolar lysosomal diseases -- Definition -- Classification -- Clinical phenotypes -- Neuropathology -- Macroscopy -- Microscopy -- Diagnostic approach -- Pathogenesis -- Other lysosomal diseases -- Peroxisomal disorders -- Definition -- Epidemiology -- Classification -- Peroxisome biogenesis defects -- Clinical phenotypes -- Neuropathology -- Macroscopy -- Microscopy -- Diagnostic approach -- Pathogenesis. , Single peroxisome enzyme/transporter defects.

Language: English