Kooperativer Bibliotheksverbund

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Format: 1 online resource (687 p.)

Edition: 1st ed.

ISBN: 1-281-79542-9 , 9786611795429 , 0-08-055958-1

Content: Parkinson's disease is the second most prevalent neurodegenerative disease and is characterized by the irreversible loss of dopamine neurons. Despite its high prevalence in society and many decades of research, the origin of the pathogenesis and the molecular determinants involved in the disorder has remained elusive. Confounding this issue is the lack of experimental models that completely recapitulate the disease state. The identification of a number of genes thought to play a role in the cell death, and development of both toxin and genetic models to explore the function of the genes both i

Note: Description based upon print version of record. , FRONT COVER; PARKINSON'S DISEASE: MOLECULAR AND THERAPEUTIC INSIGHTS FROM MODEL SYSTEMS; COPYRIGHT PAGE; CONTENTS; LIST OF CONTRIBUTORS; PREFACE; FOREWORD; PART I: CLINICAL OVERVIEW; Chapter 1: Clinical Aspects of Parkinson Disease; Clinical Features of Parkinson Disease; Diagnosis and Differential Diagnosis; Treatment; References; Chapter 2: Genetics of Parkinson's Disease; Genetics of Familial Parkinson's Disease; α-synuclein (Park1/4); Parkin (Park2); Ubiquitin Carboxyl-terminal Hydrolase L1 (Park5); Pten-induced Kinase 1 (Park6); Oncogene Dj-1 (Park7); Leucine-rich Repeat Kinase 2 (Park8) , Atpase Type 13a2 (Park9)Omi/htra Serine Peptidase 2 (Park13); Parkinsonism-plus Genes; Microtubule-Associated Protein Tau; Progranulin; GTP Cyclohydrolase I; Na[sup(+)]/K[sup(+)]-ATPase α3 Subunit; Sporadic PD, Genetic Associations and Familial Genes; Perspectives; Acknowledgements; References; Chapter 3: Neuropathology of Parkinson's Disease; Introduction; Gross and Microscopic Findings in PD; Neuropathologic Staging of PD; Molecular Biology of LBs and Neuronal Loss in PD; LBs in Other Disorders; Incidental LBs; Pure Autonomic Failure; Dementia with LBs; Dementia in PD , Relevance of Neuropathology to PD ModelsReferences; PART II: NON-HUMAN PRIMATE MODELS; Chapter 4: Introduction to: Neurotoxin-Based Nonhuman Primate Models of Parkinson's Disease; Conclusions; Acknowledgements; References; Chapter 5: Systems Level Physiology of the Basal Ganglia, and Pathophysiology of Parkinson's Disease; Introduction; Circuit Anatomy of the Basal Ganglia; General Composition of Basal Ganglia Circuits; Cell Types and Basic Neurochemistry; Direct and Indirect Pathways; Functions of Dopamine; Pathophysiology of Parkinsonism; Conclusion; References , Chapter 6: Neuroprotection for Parkinson's Disease: Clinically Driven Experimental Design in Non-Human PrimatesA Chronic (Stepwise) MPTP Primate Model; Time Course of Nigrostriatal Degeneration after Chronic MPTP Treatment; How Does that Fit with Human PD?; Additional in vivo and ex vivo Markers; A Clinically Relevant Design that Takes Advantage of the Model; Disclosure; References; Chapter 7: The Use of Aged Monkeys to Study PD: Important Roles in Pathogenesis and Experimental Therapeutics; Age-Related Decline of Motor Activity in Primates: Relationship to PD , Age-Related Downregulation of Dopaminergic Phenotype in Nigrostriatal System: Relationship to PDAge-Related Increase of α-Synuclein: Relationship to PD; Aged Monkeys as a Model of PD: Relationship to Function; So why has not aging Processes Become a More Central Factor in PD Studies?; Conclusions; References; Chapter 8: 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Mammalian Models of Parkinson's Disease: Potential Uses and Misuses of Acute, Sub-Acute, and Chronic Models; Introduction; MPTP Mouse Models of Parkinsonism , Similarities and Differences Between Acute and Sub-Acute MPTP Mouse Models , English

Additional Edition: ISBN 0-12-374028-2

Language: English