Kooperativer Bibliotheksverbund

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Format: 1 online resource (471 p.)

ISBN: 1-283-60841-3 , 9786613920867 , 0-444-53495-4

Series Statement: Handbook of clinical neurology ; 3rd ser., v. 104

Content: This volume highlights recent developments in neuro-oncology that are not only increasing the survival rate of patients, but also improving their quality of life. Through an in-depth exploration of new therapies, including advanced diagnostic tools and a fresh perspective on molecular biology, immunology, and the clinical aspects of tumors, clinicians will gain a critical understanding of emerging therapies and techniques. Extensive coverage of tumor management and new therapeutic strategies, including gene therapy and molecularly targeted treatments are also explored, providing clinicians

Note: Description based upon print version of record. , Front Cover; Neuro-Oncology; Copyright; Available titles; Foreword; Preface; List of contributors; Contents of Part I; Contents of Part II; Section 1: Basic Principles; Chapter 1: Epidemiology of primary central nervous system tumors; Introduction; Descriptive Epidemiology Of adult Malignant and Nonmalignant Central Nervous System Tumors; Incidence and Mortality; Temporal Trends; Survival; Descriptive Epidemiology of Childhood Central Nervous System Tumors; Incidence and Mortality; Temporal Trends; Survival; Genetic Epidemiology; Genetic Syndromes; Familial Aggregation , Molecular Genetic InvestigationsEnvironmental Exposures; Ionizing Radiation; Electromagnetic Fields; Mobile Phones; Smoking; Diet; Occupation; Medications; Beauty Products; Allergy; Infectious Agents; References; Chapter 2: Molecular biology of brain tumors; Introduction; Genetic Alterations and Pathogenesis in Gliomas; Diffuse Astrocytoma; Diffuse Astrocytoma to Anaplastic Astrocytoma; Transition From Anaplastic Astrocytoma To glioblastoma Multiforme; Oligodendroglial Tumors; Predictive and Prognostic Molecular Markers in Glioma; Predictive Versus Prognostic , Methylguanine-Dna Methyltransferase MethylationEpidermal Growth Factor Receptor and Phosphoinositide 3-kinase Pathway; Ykl-40; Chromosome 1p/19q Deletion In oligodendroglioma; Proliferation Markers; Microarray Profiling; Microarray Technology; Microarray Profiling Identifies Molecular Subsets of Glioma; Molecular Genetics of Meningioma; Benign/grade I Meningioma; Anaplastic/grade Iii Meningioma; Summary; References; Chapter 3: Angiogenesis and invasion in cancer; Introduction; Basic Mechanisms of Vascular development; The Angiogenic Switch; Key Players in the Angiogenic Process , Lymphangiogenesis: a New Field In angiogenesis ResearchGeneral Aspects of Tumor Angiogenesis and Lymphangiogenesis; Angiogenesis and Brain Malignancy; Invasion and Its Relation To angiogenesis in Malignant Brain Tumors; Fibronectin; Proteases and Their Inhibitors; c-Met; References; Chapter 4: Immunology of brain tumors; Introduction; General Principles of Immunology; Immunology in the Central Nervous System; Interactions of Tumor Cells With immune Cells; The Controversial Role Of microglial Cells; Tumor-derived Immunosuppression; Transforming Growth Factor-beta , Nonclassical Major Histocompatibility Complex Class I MoleculesFurther Immunosuppressive Factors; Summary and Conclusions; References; Chapter 5: Blood-brain barrier and brain edema; The Blood-brain Barrier; Physiology of the Blood-brain Barrier; Circumventing the Blood-brain Barrier; Brain Tumor Edema; Pathophysiology of Brain Tumor Edema; Tumor-specific Aspects of Edema; Therapy-associated Brain Tumor Edema; Clinical Presentation of Brain Tumor Edema; Imaging of Brain Tumor Edema; Management of Brain Tumor Edema; Complications of Edema Therapy; References; Chapter 6: Stem cells in gliomas , The Identity of Neural Stem Cells changes With Developmental Time , English

Additional Edition: ISBN 0-444-52138-0

Language: English