UID:
almahu_9948025902302882
Format:
1 online resource (973 p.)
Edition:
3rd ed.
ISBN:
1-281-02490-2
,
9786611024901
,
0-08-052552-0
Content:
Now available in its Third Edition, Asthma: Basic Mechanisms and Clinical Management has become the reference text in asthma. This highly successful text sheds new light on the basic physiological and molecular mechanisms of asthma, how current treatments work, and how best to apply the latest knowledge to control this important disease. The Third Edition has undergone radical revision and includes several new chapters. It retains the virtues of the previous volumes by bringing together all of the recent research findings by internationally recognized experts on the causative mec
Note:
Description based upon print version of record.
,
Cover; Contents; Preface; Foreword to the second edition; Contributors; Chapter 1. Epidemiology; Introduction; Diagnosis of asthma; Asthma in children; Factors influencing development of childhood asthma; Childhood asthma and AHR; Prognosis of childhood asthma; Asthma in adults; AHR in adults; Risk factors for adult asthma; Evidence for increasing severity of asthma; Mortality from asthma; Risk factors for asthma mortality; References; Chapter 2. Genetics; Introduction; Methods of finding disease genes in asthma; Problems in genetic studies of asthma
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Modes of inheritance of atopy, BHR and asthmaGenetic studies of atopy and asthma; Genetic studies of BHR and asthma; Conclusion; References; Chapter 3. Airway Pathology in Asthma; Introduction; Sputum and bronchoalveolar lavage; Appearances at post-mortem; Loss of surface epithelium; Thickening of the epithelial 'basement membrane'; Increased numbers of mucus-secreting cells; Enlargement of bronchial smooth muscle mass; Bronchial vasculature, congestion and oedema; Recruitment of inflammatory cells; Airway wall nerves; Conclusions; Acknowledgements; References; Chapter 4. Physiology
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IntroductionFactors restricting and amplifying induced airway narrowing in vivo; Sites of airway narrowing in asthma; Effects of posture and sleep on airway function; Response to increasing severity of airway narrowing; Conclusions; References; Chapter 5. Airway Smooth Muscle Cells: Structure and Function; Introduction; Morphology; Ion channels; Phosphatidylinositides and calcium; Physiological mechanisms; Conclusion; References; Chapter 6. Mast Cells and Basophils; Introduction; Mast cell heterogeneity; Mast cells. basophils and adhesion molecules
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Distribution and morphology of human lung mast cellsBAL in extrinsic asthma; Immunologically induced mediator release; BAL mast cells steroid therapy in asthma; Antiasthmatic drugs and the inhibition of histamine release from pulmonary mast cells; Role of basophils in allergy and asthma; Role of mast cells in early asthmatic reactions; Role of mast cells in late asthmatic reactions and cytokine production; Acknowledgements; References; Chapter 7. Monocytes, Macrophages and Dendritic Cells; Introduction; Role of mononuclear phagocytes in inflammatory mechanisms of asthmatic disease
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Changes in phenotype and function of monocytes and macrophages in asthmaEffects of glucocorticoids on monocyte/macrophage function; Conclusion; References; Chapter 8. Eosinophils; Introduction; Biochemistry and function; Receptors and degranulation; Mechanisms of eosinophil accumulation; The eosinophil in asthma; Monitoring of asthma by eosinophil markers; Pharmacological control of the eosinophil; Conclusions; References; Chapter 9. Lymphocytes; Introduction; Lymphocytes are strongly implicated in the pathogenesis of asthma; Overview of lymphocyte responses to inhaled foreign antigens
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Perspective: defects in termination of immune responses may cause chronic disease
,
English
Additional Edition:
ISBN 0-12-079027-0
Language:
English
