Kooperativer Bibliotheksverbund

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Format: 1 online resource (491 p.)

ISBN: 1-281-03772-9 , 9786611037727 , 0-08-053150-4

Content: Extracellular Matrix of the Liver addresses the basic science of the extracellular matrix and discussesnew strategies for the treatment of cirrhosis of the liver, with a primary focus on possible gene therapyapproaches.The chapters are divided into six sections as follows:* Basic Science of Extracellular Matrix* Cells Responsible for Extracellular Matrix Production* Activation Mechanism of Hepatic Cells and Signal Transduction* Basic Science for Extracellular Matrix Metabolism including Enzymes and their Inhibitors* Matrix Mettaloproteinases

Note: Description based upon print version of record. , Front Cover; Extracellular Matrix and the Liver; Copyright Page; Contents; Contributors; Preface; PART I: Basic Science of Extracellular Matrix; Chapter 1. New Insights into the Extracellular Matrix; I. Introduction; II. Biochemistry of Extracellular Matrix; III. Current Topics in Extracellular Matrix Research; IV. Extracellular Matrix in Liver Cirrhosis Compared with That in Normal Liver; References; Chapter 2. Dynamic Regulation of Basement Membrane Collagen IV Gene Expression in Malignant Tumors; I. Introduction; II. Tissue-Specific Expression of Collagen IV Genes , III. Supramolecular Aggregates of Collagen IVIV. Why Are Basement Membranes Important for Diagnosis in Surgical Pathology?; V. Differential Expressions of the Six a(IV) Chains in Mammary Neoplasia; VI. Protective Effects of Basement Membranes Against Cancer Invasion Due to Reorganization of a(IV) Chains; VII. Conclusion; References; Chapter 3. Regulation of Phenotypes of Human Aorta Endothelial Cells and Smooth Muscle Cells in Culture by Type IV Collagen Aggregates; I. Introduction; II. Human Aortic Smooth Muscle Cells on Type IV Collagen Gel , III. Physical Property-Determining Effects of Type IV collagen aggregatesIV. Perspectives; V. Conclusion; References; Chapter 4. Functions of Proteoglycan/Glycosaminoglycan in Liver; I. Introduction; II. Chondroitin Sulfate/Dermatan Sulfate Proteoglycans in Liver Reticulin Fiber; III. Hyaluronan as a Diagnostic Marker for Liver Cirrhosis; References; Chapter 5. SPARC, a Matricellular Protein That Regulates Cell-Matrix Interaction: Implications for Vascular and Connective Tissue Biology; I. Introduction; II. Matricellular Proteins; III. SPARC-Null Mice; IV. Perspectives; References , PART II: Cells Responsible for Extracellular Matrix ProductionChapter 6. Cells Responsible for Extracellular Matrix Production in the Liver; I. Introduction; II. Microenvironment in the Normal Liver; III. Liver Injury and Changes in Microenvironment; IV. Conclusion; References; Chapter 7. Different Hepatic Cell Populations of the Fibroblast Lineage with Fibrogenic Potential; I. Introduction; II. Approaches for the Identification and Further Characterization of the Different Hepatic Cell Populations with Fibrogenic Potential , III. Expression of Extracellular Matrix Proteins, Proteases, and Protease Inhibitors by HSC and rMFIV. Expression of Cytokines and Cell Membrane Receptors by HSC and rMF; V. Fibulin-2: A Novel Marker for the Differentiation of HSC and Rat Liver Myofibroblasts; VI. Distribution of HSC and rMF in Rat Liver Tissue; VII. HSC as a Model System to Study the Role of Cells of the Fibroblast Lineage during Tissue Repair; VIII. Outlook; References; Chapter 8. Role of Sinusoidal Endothelial Cells in Liver Inflammation and Repair; I. Introduction , II. Intercellular Adhesion Molecule-1 Upregulation on Sinusoidal Endothelial Cells Precedes Infiltration with Inflammatory Cells and Development of Necrotic Areas , English

Additional Edition: ISBN 0-12-525251-X

Language: English