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  • 1
    Online Resource
    Online Resource
    Amsterdam ; : Elsevier/Academic Press,
    UID:
    almahu_9948026549202882
    Format: 1 online resource (391 p.)
    Edition: 4th ed.
    ISBN: 1-281-11916-4 , 9786611119164 , 0-08-053126-1
    Content: Now in two-colour throughout, the fourth edition of Eukaryotic Transcription Factors has been completely rewritten and restructured to take into account the tremendous advances in our understanding of transcription factors and the mechanisms by which they act. Considerable emphasis has been given to the interaction between transcription factors and chromatin structure. Also included is an entirely new section on the mediator complex and expansion of the space devoted to co-activators and co-repressors.This book is essential reading for all those who wish to understand the impac
    Note: Description based upon print version of record. , Front Cover; Eukaryotic Transcription Factors; Copyright Page; Contents; List of Tables; About the author; Preface; Preface to the third edition; Preface to the second edition; Preface to the first edition; Acknowledgements; Chapter 1. DNA Sequences, Transcription Factors and Chromatin Structure; 1.1 The importance of transcription; 1.2 Chromatin structure and its remodelling; 1.3 DNA sequence elements; 1.4 Conclusions; Chapter 2. Methods for Studying Transcription Factors; 2.1 Introduction; 2.2 Methods for studying DNA-protein interactions , 2.3 Methods for purifying and/or cloning transcription factors2.4 Use of cloned genes; 2.5 Conclusions; Chapter 3. RNA Polymerases and the Basal Transcriptional Complex; 3.1 RNA polymerases; 3.2 The stable transcriptional complex; 3.3 RNA polymerase I; 3.4 RNA polymerase III; 3.5 RNA polymerase II; 3.6 TBP, the universal transcription factor?; 3.7 Conclusions; Chapter 4. Families of DNA Binding Transcription Factors; 4.1 Introduction; 4.2 The homeodomain; 4.3 The two cysteine two histidine zinc finger; 4.4 The multi-cysteine zinc finger; 4.5 The basic DNA binding domain , 4.6 Other DNA-binding motifs4.7 Conclusions; Chapter 5. Activation of Gene Expression by Transcription Factors; 5.1 Activation domains; 5.2 Nature of activation domains; 5.3 Interaction of activation domains with the basal transcriptional complex; 5.4 Interaction of activation domains with other regulatory proteins; 5.5 Other targets for transcriptional activators; 5.6 Conclusions; Chapter 6. Repression of Gene Expression by Transcription Factors; 6.1 Repression of transcription; 6.2 Indirect repression; 6.3 Direct repression; 6.4 Other targets for transcriptional repressors; 6.5 Conclusions , Chapter 7. Regulation of Transcription Factor Synthesis7.1 Transcription factor regulation; 7.2 Regulated synthesis of transcription factors; 7.3 Mechanisms regulating the synthesis of transcription factors; 7.4 Conclusions; Chapter 8. Regulation of Transcription Factor Activity; 8.1 Evidence for the regulated activity of transcription factors; 8.2 Regulation by protein-ligand binding; 8.3 Regulation by protein-protein interactions; 8.4 Regulation by protein modification; 8.5 Regulation by protein degradation and processing; 8.6 Role of regulated activity; 8.7 Conclusions , Chapter 9. Transcription Factors and Human Disease9.1 Diseases caused by transcription factor mutations; 9.2 Cancer; 9.3 Cellular oncogenes and cancer; 9.4 Anti-oncogenes and cancer; 9.5 Conclusions; Chapter 10. Conclusions and Future Prospects; Index; Color Plate Section , English
    Additional Edition: ISBN 0-12-437178-7
    Language: English
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