UID:
almahu_9948197287102882
Umfang:
1 online resource (xxviii, 470 pages) :
,
illustrations
ISBN:
9780470411285
,
0470411287
,
0470229640
,
9780470229644
,
9780470411292
,
0470411295
,
1282002066
,
9781282002067
Inhalt:
The serious nature of cardiovascular adverse drug reactions occurring in patients makes assessment of a drug's cardiac safety profile a high priority during both development and post-approval monitoring. Integrated Cardiac Safety provides necessary guidance and methodology for professionals assessing cardiac safety of drugs throughout all stages of the drug's life, from discovery and development through postmarketing research. This self-contained, reader-friendly text is valuable to professionals in the pharmaceutical, biotechnology, and CRO industries, pharmacologists, toxicologists, governm.
Anmerkung:
The importance of cardiac safety assessments -- The biological basis of adverse drug reactions -- Cardiac structure and function -- Cardiac pathophysiology and disease -- Drug discovery and drug design -- Nonclinical development -- The thorough QT/QTc trial -- General safety assessments -- Therapeutic use trials and meta-analyses -- Assessment methodologies in nonexperimental postmarketing surveillance -- Postmarketing proarrhythmic cardiac safety assessments -- Generalized cardiac safety -- Medication errors, adherence, and concordance -- Future directions in drug safety.
Weitere Ausg.:
Print version: Turner, J. Rick. Integrated cardiac safety. Hoboken, N.J. : John Wiley & Sons, ©2009 ISBN 0470229640
Weitere Ausg.:
ISBN 9780470229644
Sprache:
Englisch
Schlagwort(e):
Electronic books.
DOI:
10.1002/9780470411292
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9780470411292
