UID:
almafu_9960117963602883
Umfang:
1 online resource (ix, 82 pages) :
,
digital, PDF file(s).
ISBN:
1-108-51581-9
,
1-108-50687-9
,
1-107-36004-8
Serie:
Cambridge medicine
Inhalt:
Engage with the visual world of disease with this accessible introduction to molecular imaging. This book provides users of all levels with the characterization and measurement of biological processes on a cellular level, functioning within humans, and other living systems. This important new introduction to the field will enable the reader to recognize the major methods, modalities and varied applications of molecular imaging in an efficient and effective way. Featuring techniques from areas such as nuclear medicine, magnetic resonance spectroscopy, optical imaging, and nanotechnology, the book also covers the current movement towards precision medicine thereby driving exceptional hospital care, worldwide. Molecular Imaging provides valuable insight into the properties that improve patient diagnosis. Serving to inform experienced physicians, students, and beginners alike, this convenient introduction is tailored to an individual with the desire to effectively grasp the basic concepts of molecular imaging, under the constraints of a busy professional career.
Anmerkung:
Title from publisher's bibliographic system (viewed on 27 Nov 2017).
,
Cover -- Half-title -- Title page -- Copyright information -- Table of contents -- List of contributors -- Preface -- 1 Instrumentation - CT -- 1.1 Introduction to CT -- 1.2 Concepts of Attenuation and CT Number -- 1.3 Principles of CT Image Acquisition, and Helical CT -- 1.4 Multislice CT and Dual-Energy CT -- 1.5 CT Hardware Components -- 1.6 CT Image Reconstruction -- 1.7 Advanced CT Image Post Processing and Display Techniques -- 1.8 CT Image Quality and Radiation Dose -- 2 MRI/MRS Instrumentation and Physics -- 2.1 Magnetic Resonance Fundamentals -- 2.2 MR Hardware -- 2.3 T1 and T2 Relaxation Time Constants -- 2.4 Image Contrast -- 2.5 Overview of Pulse Sequences -- 2.6 Fast Imaging Sequences -- 2.7 Dynamic Contrast-Enhanced MRI (DCE-MRI) -- 2.8 Diffusion Weighted Imaging (DWI-MRI) -- 2.9 Magnetic Resonance Spectroscopy (MRS) -- 2.10 MR Safety -- 3 Optical and Ultrasound Imaging -- 3.1 Optical Imaging -- 3.1.1 Fundamental Issues -- 3.1.2 Fluorescence Imaging -- 3.1.2.1 Fluorescent Molecules -- 3.1.2.2 Tissue Illumination -- 3.1.2.3 Detection Systems -- 3.1.3 Bioluminescence Imaging -- 3.1.4 Photoacoustic Imaging -- 3.2 Ultrasound Imaging -- Further Reading -- 4 Instrumentation-Nuclear Medicine and PET -- 4.1 Dose Calibrator -- 4.2 Well Counter -- 4.3 Gamma Camera -- 4.4 Single Photon Emission Computed Tomography (SPECT) -- 4.5 Positron Emission Tomography (PET) -- 5 Quantitation-Nuclear Medicine -- 5.1 Biodistribution -- 5.2 Indicator Dilution -- 5.3 Left-Right Comparisons -- 5.4 Partial Volume Effect -- 5.5 Planar Attenuation Correction -- 5.5.1 SPECT Attenuation Correction -- 5.5.2 Positron Emission Tomography Attenuation Correction -- 5.6 Standardized Uptake Value (SUV) -- 5.7 Simplified Kinetic Analysis -- 5.8 Patlak Graphical Analysis -- Further Reading -- 6 Perfusion -- 6.1 Microspheres -- 6.2 Myocardial Perfusion.
,
6.3 Cerebral Perfusion with Retained Agents -- 6.4 Cerebral Perfusion with Diffusible Agents -- 6.5 Cerebral Blood Flow with MRI -- 6.6 Cerebral Blood Flow with CT -- Further Reading -- 7 Metabolism -- 7.1 Glucose -- 7.2 Acetate -- 7.3 Choline -- Further Reading -- 8 Cellular Proliferation -- 8.1 [18F]-FLT -- 8.2 18F-FMAU -- Further Reading -- 9 Hypoxia -- 9.1 Direct Measurement of Tissue Oxygen -- 9.2 Magnetic Resonance Spectroscopy (MRS) -- 9.3 Electron Paramagnetic Resonance (EPR) -- 9.4 Radiolabeled Tracers for Detection of Hypoxia -- Further Reading -- 10 Receptor Imaging -- 10.1 Receptor Ligands -- 10.1.1 Oligopeptide Ligands -- 10.1.2 Antibodies -- 10.1.3 Aptamers -- 10.1.4 Small Molecules -- 10.1.5 Quantitative Characterization of Receptor Ligands -- Further Reading -- 11 Apoptosis -- 11.1 The Apoptosis Cellular Pathway -- 11.2 Agents for Molecular Imaging of Apoptosis -- 11.2.1 Annexin V -- 11.2.2 Radiolabeled Small Molecules -- 11.3 Clinical Applications for Apoptosis Imaging -- 11.3.1 Cardiology -- 11.3.2 Neurology -- 11.3.3 Oncology -- Further Reading -- 12 Angiogenesis -- Further Reading -- 13 Reporter Genes -- 13.1 Introduction -- 13.2 Enzyme-Based Reporter Genes -- 13.2.1 Herpes Simplex Virus 1 Thymidine Kinase -- 13.2.2 Mitochondrial Thymidine Kinase-2 -- 13.2.3 Deoxycytidine Kinase -- 13.3 Receptor-Based Reporters -- 13.3.1 Somastatin Receptor (SSTr) -- 13.3.2 Dopamine Type 2 Receptor (D2R) -- 13.3.3 Other Receptor-Based Reporters -- 13.4 Transporter-Based Reporters -- 13.4.1 Sodium Iodide Symporter (NIS) -- 13.4.2 Norepinephrine Transporter (NET) -- 13.5 Criteria for Effective Reporter Gene Imaging -- Further Reading -- 14 Stem Cell Tracking -- 14.1 Methods to Visualize Stem Cell Homing and Engraftment -- 14.1.1 Ex Vivo Labeling of the Stem Cells with a Contrast Agent or Radiotracer Prior to Implantation.
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14.2 Methods to Visualize Stem Cell Differentiation In Vivo -- 14.3 Methods to Visualize Immune Responses to Stem Cell Transplants -- Further Reading -- 15 Amyloid Imaging -- 15.1 Introduction -- 15.2 Beta Amyloid Plaques and Pathologic Basis for Alzheimer's Disease -- 15.3 Radiopharmaceuticals for Aß Amyloid PET Imaging -- 15.3.1 Carbon-11 Pittsburgh Complex B -- 15.3.2 Fluorine-18 Labeled Amyloid Imaging Agents -- 15.3.3 Technique for Interpretation of Brain Amyloid PET Imaging -- 15.4 Clinical Applications of Brain Aß Amyloid PET Imaging -- 15.5 Other Clinical Applications and Radiopharmaceuticals -- 15.5.1 Amyloid Imaging of the Heart -- 15.5.2 Imaging of Systemic Amyloidosis -- Further Reading -- Index.
Weitere Ausg.:
ISBN 1-107-62128-3
Sprache:
Englisch
URL:
https://doi.org/10.1017/9781107360044
