UID:
almafu_9959234418302883
Umfang:
1 online resource (viii, 150 pages) :
,
illustrations
ISBN:
0-262-26467-6
,
0-262-28398-0
,
0-585-44259-2
Inhalt:
The traditional model of synapses as fixed structures has been replaced by a dynamic one in which synapses are constantly being deleted and replaced. This book, written by a leading researcher on the neurochemistry of schizophrenia, integrates material from neuroscience and cell biology to provide a comprehensive account of our current knowledge of the neurochemical basis of synaptic plasticity. The book presents the evidence for synaptic plasticity, an account of the dendritic spine and the glutamate synapse with a focus on redox mechanisms, and the biochemical basis of the Hebbian synapse. It discusses the role of endocytosis, special proteins, and local protein synthesis. Additional topics include volume transmission, arachidonic acid signaling, hormonal modulation, and psychological stress. Finally, the book considers pharmacological and clinical implications of current research, particularly with reference to schizophrenia and Alzheimer's disease.
Anmerkung:
"A Bradford book."
,
Machine generated contents note: Chapter 1 -- Synaptic Biochemistry 1 -- 1.1 Introduction 1 -- 1.2 Evidencefor Synaptic Plasticity 5 -- 1.3 An Introduction to the Glutamate Synapse and Its Redox-Related -- Biochemical Features 6 -- 1.4 Biochemical Factors in Synaptic Plasticity 9 -- 1.5 The Biochemical Basis of the Hebbian Synapse 12 -- 1.6 More Redox Reactions at the Synapse 15 -- Chapter 2 -- Endocytosis and Exocytosis 27 -- 2.1 The Role of Endocytosis 27 -- 2.2 Some Enzymes Involved in Endocytosis 35 -- 2.3 Exocytosis 37 -- 2.4 Ubiquitation 38 -- 2.5 The Special Case of Endocytosis in Neurons 40 -- 2.6 The Functional Significance of Membrane and Receptor -- Endocytosis 41 -- Chapter 3 -- Special Proteins 47 -- 3.1 The Role of Cell Adhesion Molecules 47 -- 3.2 Scaffolding Proteins 55 -- 3.3 Axon Growth-Directing Proteins 60 -- 3.4 Role of Neurotropins 62 -- 3.5 Role of Actin 64 -- 3.6 Role of Local Protein Synthesis 64 -- Chapter 4 -- Miscellaneous Items 67 -- 4.1 Volume Transmission and Spillover 67 -- 4.2 Other Neurotransmitters 69 -- 4.3 Arachidonic Acid Signaling 75 -- 4.4 Hormonal Modulation of Synaptic Plasticity 76 -- 4.5 Psychological Stress 76 -- 4.6 Energy 77 -- 4.7 The Role of Astrocytes 77 -- Chapter 5 -- Pharmacological Implications and Clinical Applications 79 -- 5.1 Pharmacological Implications 79 -- 5.2 Clinical Applications 80 -- Chapter 6 -- Conclusions 91 -- Appendix A -- mRNAs Whose Level Is Altered Following Glutamate Receptor -- Stimulation 93 -- Appendix B -- Receptors That Are Endocytosed 97.
,
English
Weitere Ausg.:
ISBN 0-262-19473-2
Sprache:
Englisch
URL:
OCLC metadata license agreement
