UID:
almahu_9949386496702882
Format:
1 online resource :
,
illustrations (black and white, and colour).
ISBN:
9781003045410
,
1003045413
,
9781000067392
,
1000067394
,
9781000067385
,
1000067386
,
9781000067378
,
1000067378
,
9781000067354
,
1000067351
,
9781000067361
,
100006736X
,
9781003045397
,
1003045391
Series Statement:
Jenny Stanford series on biocatalysis ; volume 6
Content:
This volume of Pharmaceutical Biocatalysis starts with a discussion on the importance of biocatalytic synthesis approaches for a sustainable and environmentally friendly production of pharmaceuticals and active pharmaceutical ingredients. Among the enzymes discussed in detail with respect to their pharmaceutical relevance are cyclic nucleotide phosphodiesterases playing an important role in modulating signal transduction in various cell types; human DOPA decarboxylase, related to Parkinson's disease and aromatic amino acid decarboxylase deficiency; and phospholipase D enzymes as drug targets. Isocitrate dehydrogenase 1 and 2 mutations are novel therapeutic targets in acute myeloid leukemia. An additional chapter is devoted to the use of enzymes for prodrug activation in cancer therapy. The other topics include small-molecule inhibitors targeting receptor tyrosine kinases in cancer, -Lactams and related compounds as antibacterials, non-vitamin K oral anticoagulants for the treatment of thromboembolic diseases, and the molecular mechanisms for statin pleiotropy and its clinical relevance in cardiovascular diseases. The last chapter is a review of lysosomal storage disorders with an overview of approved drugs for treating these disorders by enzyme replacement therapy.
Note:
Cover -- Half Title -- Series Page -- Title Page -- Copyright Page -- Contents -- Preface -- 1. Lipase-Mediated Biocatalysis as a Greener and Sustainable Choice for Pharmaceutical Processes -- 1.1 Introduction -- 1.2 Hydrolases as Biocatalysts -- 1.2.1 Lipases: A General Account -- 1.2.1.1 Structural features of lipases -- 1.2.1.2 Reaction mechanism of lipases -- 1.2.1.3 Properties of lipases -- 1.2.2 Lipase-Catalyzed Synthesis of Active Pharmaceutical Ingredients and Intermediates -- 1.2.2.1 Non-steroidal antiinflammatory drugs -- 1.2.2.2 Angiotensin-converting enzyme inhibitors
,
1.2.2.15 Cathepsin K inhibitor: Odanacatib intermediate -- 1.3 Commercial Success through Green Technologies -- 1.4 Future Perspectives -- 1.4.1 Protein Engineering -- 1.4.2 Directed Evolution -- 1.4.3 Artificial Intelligence -- 1.5 Conclusion -- 2. Phosphodiesterases -- 2.1 Introduction -- 2.2 Classification of PDE Subfamilies -- 2.3 Structural Aspects of Phosphodiesterases -- 2.4 Non-Specific Inhibition of Phosphodiesterases -- 2.5 Phosphodiesterase 3 -- 2.5.1 Structure, Function and Regulation of PDE3 -- 2.5.2 Inhibition of PDE3 -- 2.6 Phosphodiesterase 4
,
2.6.1 Structure, Function and Regulation of PDE4 -- 2.6.2 Inhibition of PDE4 -- 2.7 Phosphodiesterase 5 -- 2.7.1 Structure, Function and Regulation of PDE5 -- 2.7.2 Inhibition of PDE5 -- 2.8 Concluding Remarks -- 3. Human DOPA Decarboxylase: Catalysis and Involvement in Pharmacological Treatments for Parkinson's Disease and Aromatic Amino Acid Decarboxylase Deficiency -- 3.1 Introduction -- 3.2 Structure of DDC -- 3.3 Catalysis of DDC -- 3.4 Drugs Used to Counteract DDC Loss in PD or Loss-of-Function in AADC Deficiency -- 3.5 Conclusions
,
4. Advancing Phospholipase D Enzymes as Diverse Drug Targets -- 4.1 Introduction -- 4.2 Non-HKD PLD as a Target for Infectious Diseases and Envenoming -- 4.3 Non-HKD PLD as a Target for Cancer, Inflammatory and Neurodegenerative Diseases -- 4.4 Human PLD Inhibitors Are Potential Drugs for Cancer, Cardiovascular Disease, Infectious Diseases, and Neurodegenerative Diseases -- 4.5 Concluding Remarks -- 5. IDH1 and IDH2 Mutations as Novel Therapeutic Targets in Acute Myeloid Leukemia: Current Perspectives -- 5.1 Introduction -- 5.2 Normal Functions of IDH Enzymes
Additional Edition:
Print version: ISBN 9789814877138
Language:
English
Keywords:
Electronic books.
;
Electronic books.
DOI:
10.1201/9781003045397
URL:
https://www.taylorfrancis.com/books/9781003045397
