UID:
almahu_9949419393302882
Umfang:
XVIII, 522 p.
,
online resource.
Ausgabe:
1st ed. 2011.
ISBN:
9783642179693
Serie:
Handbook of Experimental Pharmacology, 204
Inhalt:
Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.
In:
Springer Nature eBook
Weitere Ausg.:
Printed edition: ISBN 9783642179686
Weitere Ausg.:
Printed edition: ISBN 9783642269455
Weitere Ausg.:
Printed edition: ISBN 9783642179709
Sprache:
Englisch
DOI:
10.1007/978-3-642-17969-3
URL:
https://doi.org/10.1007/978-3-642-17969-3
