UID:
almahu_9949600168902882
Umfang:
1 online resource (174 pages)
Ausgabe:
First edition.
ISBN:
0-323-91141-2
,
0-323-99846-1
Inhalt:
Steroid Hormone Receptors in Endocrine Physiology and Diseases covers the role of steroid hormones in human physiology and receptor activity in the pathophysiology of disease. The book discusses how these receptors can be used as therapeutic targets for the treatment of conditions from cancer to aging, offering immediate applications of biochemical principles into clinical applications such as diagnosis and treatment. This book is a valuable reference for graduate and postdoctoral scientists but is also ideal for medical students interested in the functional role of various steroid hormone receptors in a wide variety of endocrine related diseases.
Anmerkung:
Front Cover -- Steroid Hormone Receptors in Health and Disease -- Copyright Page -- Contents -- Preface -- 1 A brief history of steroid hormones and steroid receptor biology -- Introduction -- Steroid hormones -- Discovery, purification, and synthetic synthesis of steroid hormones -- Receptor proteins and mechanism of hormone action -- Conclusions and future perspectives -- References -- 2 Hormone-dependent cancers -- Introduction -- Breast cancer -- Prostate cancer -- Hormone therapy -- Resistance to hormone therapy -- Ovarian cancer -- Endometrial cancer -- Conclusions -- References -- 3 Steroids and cardiovascular and metabolic disorders -- Introduction -- Metabolic syndrome -- Meabolic disorders and steroid hormone receptors -- Role of GR in obesity -- Role of MR in hypertension -- Role of ER in cardiovascular diseases -- Role of PR in metabolic disorders -- Conclusions and future perspectives -- References -- 4 Steroid hormone receptors in aging and neurodegenerative diseases -- Introduction -- Aging -- Neurodegenerative diseases -- Steroid hormone receptors and aging -- Steroid hormone receptors and neurodegenerative diseases -- Conclusions and future perspectives -- References -- 5 Steroid hormones and infection and immunity -- Introduction -- Role of hypothalamic-pituitary-adrenal and hypothalamic-pituitary-gonadal axis in immunity -- Steroid hormone receptors regulation of immune responses in cancer -- Steroidogenesis and its role in immune regulation -- Influence of sex hormones on vaccine-induced immunity -- Glucocorticoids, inflammation, and autoimmune diseases -- Steroid hormones and COVID-19 -- Conclusions and future perspectives -- References -- 6 Endocrine disruptors: the enemy without -- Introduction -- Chemical nature of EDCs -- Mechanism of action -- Bisphenol-A -- Organochloro-pesticides -- Polychlorinated biphenyls.
,
Parabens -- Benzophenones -- Impact of EDC on human health-results from animal studies and human cohorts -- Female reproduction -- Male Reproduction -- Conclusions and future perspectives -- References -- 7 The gut microbiota-as an endocrine organ -- Introduction -- Steroid biosynthesis and metabolism -- The gut microbiota and sex differences -- The gut microbiota and sex hormones -- Gut microbiota associated with life events, age and sex differences -- The gut microbiota and hormone cancer therapy -- Breast -- Prostate -- Conclusion and future perspectives -- References -- 8 Summary and future perspectives -- Steroid receptor structure and tissue-specific gene regulation -- Steroid receptors and metabolism -- Steroid hormones and receptors in healthy aging -- Environmental impacts on steroid receptor function -- The gut microbiota and steroid hormone levels and signaling -- Concluding remarks -- Index -- Back Cover.
Sprache:
Englisch
