UID:
almahu_9949697544002882
Umfang:
1 online resource (617 p.)
ISBN:
1-283-73503-2
,
0-12-388416-0
Inhalt:
Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epig
Anmerkung:
Includes index.
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Front Cover; Epigenetics in Human Disease; Copyright; Contents; Preface; Contributors; Chapter 1 - Epigenetics of Human Disease; 1.1 INTRODUCTION; 1.2 EPIGENETIC VARIATION METHODS; 1.3 CANCER EPIGENETICS; 1.4 EPIGENETICS OF NEUROLOGICAL DISEASE; 1.5 AUTOIMMUNITY AND EPIGENETICS; 1.6 HUMAN IMPRINTING DISORDERS; 1.7 EPIGENETICS OF OBESITY; 1.8 DIABETES: THE EPIGENETIC CONNECTION; 1.9 EPIGENETICS AND ALLERGIC DISORDERS; 1.10 CARDIOVASCULAR DISEASE AND EPIGENETICS; 1.11 EPIGENETICS OF HUMAN INFECTIOUS DISEASES; 1.12 REPRODUCTIVE DISORDERS AND EPIGENETIC ABERRATIONS
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1.13 STEM CELL EPIGENETICS IN HUMAN DISEASE1.14 EPIGENETICS OF AGING AND AGE-ASSOCIATED DISEASES; 1.15 CONCLUSION; References; Chapter 2 - Methods and Strategies to Determine Epigenetic Variation in Human Disease; 2.1 INTRODUCTION; 2.2 DNA METHYLATION ANALYSIS; 2.3 HISTONE MODIFICATION ANALYSIS; 2.4 NON-CODING RNA ANALYSIS: MICRORNA; 2.5 ANALYSIS OF GENOME DNA REPLICATION PROGRAM BASED ON DNA REPLICATION TIMING; 2.6 STRATEGY FOR EPIGENOMIC INVESTIGATION BASED ON CHROMOSOMAL BAND STRUCTURES; 2.7 OVERVIEW OF RECENT EPIGENETIC GENOME-WIDE OR BIOINFORMATIC STUDIES AND STRATEGIES
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2.8 GENERAL OVERVIEW AND FUTURE PERSPECTIVEReferences; Chapter 3 - DNA Methylation Alterations in Human Cancers; 3.1 INTRODUCTION: BIOLOGICAL ROLES OF DNA METHYLATION; 3.2 DNA METHYLATION ALTERATIONS IN HUMAN CANCERS; 3.3 ABERRANT DNA METHYLATION IN PRECANCEROUS CONDITIONS ASSOCIATED WITH CHRONIC INFLAMMATION, PERSISTENT VIRAL INFE ...; 3.4 ABNORMAL EXPRESSION OF DNMTS IN HUMAN CANCERS; 3.5 MUTATIONS, POLYMORPHISM AND SPLICING ALTERATIONS OF DNMTS AND HUMAN CANCERS; 3.6 SIGNAL PATHWAYS AFFECTING DNA METHYLATION STATUS DURING TUMORIGENESIS; 3.7 DNA METHYLATION AND HISTONE MODIFICATIONS
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3.8 SUBCLASSIFICATION OF HUMAN CANCERS BASED ON DNA METHYLATION PROFILING3.9 DIAGNOSIS OF CANCERS IN BODY FLUIDS AND BIOPSY SPECIMENS BASED ON DNA METHYLATION PROFILES; 3.10 CARCINOGENETIC RISK ESTIMATION BASED ON DNA METHYLATION PROFILES; 3.11 PERSONALIZED MEDICINE BASED ON DNA METHYLATION PROFILES: PROGNOSTICATION OF PATIENTS WITH CANCERS AND PREDICT ...; 3.12 NEW TECHNOLOGIES FOR DNA METHYLATION ANALYSIS AND FUTURE DIRECTIONS; References; 4 - Alterations of Histone Modifications in Cancer; 4.1 INTRODUCTION; 4.2 CHROMATIN ORGANIZATION; 4.3 HISTONE MODIFICATIONS
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4.4 HISTONE MODIFICATIONS AND CANCER4.5 MECHANISMS UNDERLYING HISTONE ALTERATIONS IN CANCER; 4.6 CONCLUSIONS; References; 5 - MicroRNA in Oncogenesis; 5.1 INTRODUCTION; 5.2 MIRNA BIOGENESIS; 5.3 MIRNA-MEDIATED REGULATION OF TARGETS; 5.4 MIRNA AND CANCER; 5.5 ONCOMIRS; 5.6 MECHANISMS OF MIRNA DEREGULATION; 5.7 MIRNA AND TREATMENT RESISTANCE; 5.8 CLINICAL APPLICATIONS; References; 6 - Epigenetic Approaches to Cancer Therapy; 6.1 INTRODUCTION; 6.2 HISTONE ACETYLATION; 6.3 HISTONE DEACETYLASES; 6.4 HISTONE METHYLATION AND DEMETHYLATION; 6.5 DNA METHYLATION; 6.6 ACETYLATION OF NON-HISTONE PROTEINS
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6.7 FUTURE DIRECTIONS
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English
Weitere Ausg.:
ISBN 0-12-388415-2
Sprache:
Englisch
