UID:
almahu_9949697664802882
Umfang:
1 online resource (283 p.)
ISBN:
1-281-05714-2
,
9786611057145
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0-08-053322-1
Inhalt:
Handbook of the Aging Brain brings together diverse scientific disciplines to cover the most recent research findings in an easy-to-read summary. Scientists and clinicians will find a wide spectrum of subjects including gerontology, neurology, psychology, molecular biology, and cellular biology. The book includes general chapters on the neuroanatomy and neurobiology of the aging brain, and moves on to discussion of specifics including signal transduction, cell death, and specific cellular and neurological changes associated with dementia, Alzheimer's and Parkinson's Disease. Other chapt
Anmerkung:
Description based upon print version of record.
,
Front Cover; Handbook of the Aging Brain; Copyright Page; Contents; Contributors; Preface; CHAPTER 1. NORMAL AND ABNORMAL MEMORY: AGING AND ALZHEIMER'S DISEASE; Age-Related Changes in Memory; Age-Related Changes in Brain Structure and Function; Memory Changes in Early Alzheimer's Disease; Changes in Brain Structure in Early Alzheimer's Disease; Conclusion; References; CHAPTER 2. STRESS, GLUCOCORTICOIDS, AND HIPPOCAMPAL AGING IN RAT AND HUMAN; HPA Axis; Glucocorticoids and Aging; Consequences of Elevated Glucocorticoid Levels; Glucocorticoids and Hippocampal Electrophysiology
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Glucocorticoids and Synaptic Plasticity LevelsConsequences of Elevated Glucocorticoid Levels: Neuronal Survival; Individual Differences in HPA Activity and Brain Aging; Glucocorticoids and Human Aging; Glucocorticoids and Age-Related Neuropathology in Humans; Glucocorticoids and Human Cognition; HPA Function and Hippocampal Aging in Humans; Subgroups of Elderly Subjects with Regard to Patterns of Cortisol Secretion over Years; Cognitive Deficits Related to Hippocampal Damage in Relation to Subgroups; References; CHAPTER 3. SPATIAL COGNITION AND FUNCTIONAL ALTERATIONS OF AGED RAT HIPPOCAMPUS
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Technical Advances in Single Cell Recording StudiesDo Old Rats Have Broader, Less Reliable Place Fields?; Effects of Cue and Task Demand Manipulations on Place Cell Firing Properties of Young and Old Rats; Differences between Studies That Remain Unexplained; Spatial Selectivity: Interaction with Experience during a Recording Session; Multistability of Place Cell Maps in Old Rats; Summary and Conclusions; References; CHAPTER 4. IDENTIFICATION OF MOLECULAR AND CELLULAR MECHANISMS OF LEARNING AND MEMORY: THE IMPACT OF GENE TARGETING; LTP as a Cellular Mechanism for L&M
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Short-Term Plasticity and LearningSpiking and Learning; Future of Genetic Techniques; Conclusions; References; CHAPTER 5. NORMAL AGING AND ALZHEIMER'S DISEASE; Text; References; CHAPTER 6. TRANSGENIC MOUSE MODELS WITH NEUROFILAMENT-INDUCED PATHOLOGIES; Neurofilament Structure and Function; Perturbations of Neurofilament Metabolism in Neurodegenerative Diseases and in Aging; Mouse Models with Neurofilament Pathologies; Interference of Axonal Transport by Disorganized Neurofilaments; NF-H Mutations in Amyotrophic Lateral Sclerosis; A Link between Neurofilaments and Oxidative Stress?
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Future DirectionsReferences; CHAPTER 7. TRANSGENIC MODELS OF AMYOTROPHIC LATERAL SCLEROSIS AND ALZHEIMER'S DISEASE; Transgenic Approaches; Amyotrophic Lateral Sclerosis and Transgenic Mice with SOD1 Mutations; Alzheimer's Disease and Transgenic Mice with APP or PS 1 Mutations; Conclusions; References; CHAPTER 8. TOWARD A GENETIC ANALYSIS OF UNUSUALLY SUCCESSFUL NEURAL AGING; A Brief Primer of Evolutionary Biological Aspects of Relevant Gene Action; Some Implications of the Evolutionary Biological Theory of Aging for Human Neurobiology; Nature-Nurture Interactions
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Approaches to the Genetic Analysis of Unusually Well-Preserved Cognitive Function
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English
Weitere Ausg.:
ISBN 0-12-734610-4
Sprache:
Englisch
