UID:
almahu_9949697722202882
Umfang:
1 online resource (537 p.)
Ausgabe:
1st ed.
ISBN:
1-281-09619-9
,
9786611096199
,
0-08-055602-7
Serie:
Strategies and Tactics in Organic Synthesis
Inhalt:
A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic. Rather than a simple presentation of data or a second-hand analysis, we are given stories that vividly demonstrate the power of the human endeavour known as organic synthesis and the creativity and tenacity of its practitioners. First hand accounts of each project tell of the excitement of conception, the frustration of failure and the joy experienced when either rational thought and/or good fortune give rise to
Anmerkung:
Description based upon print version of record.
,
Cover; Dedication; Contents; Contributors; Preface; Foreword; Chapter 1. Total Synthesis of RK-397; I. Introduction and Background; II. Retrosynthetic Analysis; III. Synthesis of RK-397; IV. Completion of the Synthesis; V. Summary; Acknowledgements; References and Footnotes; Chapter 2. A Formal Total Synthesis of the Marine Diterpenoid, Diisocyanoadociane; I. Introduction and Background; II. Synthesis Plan; III. Foundations and Proof of Concept; IV. Elaboration of the D-Ring; V. Elaboration of the B-ring and Exploration of the Michael Reaction
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VI. Improved Synthesis of an Advanced Tetracyclic IntermediateVII. Deoxygenation, Curtius Rearrangement, and Completion of the Synthesis; IX. Epilogue; Acknowledgments; References and Footnotes; Chapter 3. Total Syntheses of Zoapatanol; I. Introduction; II. Nicolaou's Synthesis; III. Chen's Synthesis; IV. Cookson's Synthesis; V. Kocienski's Synthesis; VI. Kane's Synthesis; VII. Trost's Synthesis; VIII. Our Approaches for the Total Synthesis of (+)-Zoapatanol; IX. Conclusion; References and Footnotes
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Chapter 4. Synthesis of Molecular Tweezers and Clips by the use of a Molecular Lego Set and Their Supramolecular FunctionsI. Introduction and Background; II. Retrosynthetic Analysis; III. Preparation of the Molecular Building Blocks; IV. Synthesis of Molecular Tweezers and Clips; V. Thermodynamic Parameters of Host-Guest Complex Formation with Molecular Tweezers and Clips; VI. Host-Guest Structures and Dynamics; VII. Synthesis of Water-Soluble Molecular Tweezers and Clips; VIII. Binding of Biologically Interesting Substrates such as Enzyme Cofactors and Nucleosides in Aqueous Solution
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IX. ConclusionAcknowledgments; References and Footnotes; Chapter 5. Application of C-Glycosides in the Total Synthesis of (Š)-Gambierol; I. Introduction and Background; II. Preliminary Studies; III. Synthetic Strategies; IV. Total Synthesis of (Š)-Gambierol; V. Summary; Acknowledgements; References and Footnotes; Chapter 6. A Biomimetic Approach to the Rocaglamides Employing Photogeneration of Oxidopyryliums Derived from 3-Hydroxyflavones; I. Introduction and Background; II. Synthetic Strategies: A Biomimetic Approach via Photogeneration of Oxidopyryliums
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III. Synthesis of (Š)-Methyl Rocaglate and Related Natural ProductsIV. Enantioselective Synthesis of Rocaglamide Using Chiral Brønsted Acid; V. Summary; Acknowledgments; References and Footnotes; Chapter 7. Synthesis Studies of Dolabellanes and Transannular Processes Leading to Related Diterpenes; I. Introduction and Background; II. Biosynthesis; III. Preliminary Studies; IV. Synthesis of a Dolastane via a Dolabellane Precursor; V. Fusicoccane Synthesis via a Dolabellane Progenitor: Total Synthesis of (+)-Fusicoauritone; VI. Summary; Acknowledgments; References and Footnotes
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Chapter 8. Diphenyloxazinones: Versatile Templates for the Asymmetric Synthesis of a-Amino Acids, Peptide Isosteres, and Natural Products
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English
Weitere Ausg.:
ISBN 0-12-373903-9
Sprache:
Englisch
