UID:
almahu_9949697783702882
Format:
1 online resource (795 p.)
ISBN:
1-281-03295-6
,
9786611032951
,
0-08-053855-X
Content:
Pediatric Bone is the first book to be published to deal exclusively with the biology and diseases of bone as they affect children. Rapid advances have been made in our understanding of the mechanisms and factors controlling the growth and development of bone, and these are discussed in detail in this book. Further, the various diseases of bone which are peculiar to children are highlighted and discussed in the light of our current knowledge with regard to the causation, clinical signs and treatment. The book is aimed to provide those clinicians interested in children's diseases and bas
Note:
Description based upon print version of record.
,
Front Cover; Pediatric Bone: Biology and Diseases; Copyright Page; Table of Contents; Contributors; Foreword; Preface; Chapter 1. Structure of Growth Plate and Bone Matrix; Introduction; Type I Collagen; Type V Collagen; Type II Collagen; Type IX Collagen; Type XI Collagen; Type X Collagen; Aggrecan; Cartilage Link Protein 1; Small, Leucine-Rich, Interstitial Proteoglycans; Perlecan; Matrilins; Thrombospondins; Osteonectin; Osteocalcin; Matrix Gla Protein; Bone Sialoprotein; Bone Acidic Glycoprotein-75; Dentin Matrix Acidic Phosphoprotein-1; Osteopontin; References
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Chapter 2. Bone Cell Biology: Osteoblasts, Osteocytes, and OsteoclastsIntroduction; Ontogeny of Osteoblasts and Control of Osteoblast Development; Osteoprogenitor Cells and Regulation of Osteoblast Differentiation and Activity; Regulation of Osteoblast Differentiation and Activity; Osteocytes; Morphological Features of Osteoclasts; Mechanisms of Osteoclastic Bone Resorption; Origin of Osteoclasts; Regulation of Ostoclast Activity and Differentiation; Osteoclast Size: Multinucleation and Function; Stem Cell, Osteoblast, and Osteoclast Changes in Disease
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Tissue Engineering and Stem Cell Therapy for Skeletal DiseasesReferences; Chapter 3. Prenatal Bone Development: Ontogeny and Regulation; Introduction; Skeletogenesis; Skeletal Organization and Embryonic Origin of Bones; Molecular Regulation of Bone Formation; References; Chapter 4. Postnatal Bone Growth: Growth Plate Biology, Modeling, and Remodeling; Endochondral and Intramembranous Bone Formation; Growth Hormone and Insulin-Like Growth Factor- 1; Fibroblast Growth Factors; Thyroid Hormone; Estrogen and Androgen; Osteoblasts and Bone Growth; Endocrine Regulation of Bone Formation; References
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Chapter 5. Parathyroid Hormone and Calcium HomeostasisCellular and Extracellular Calcium Homeostasis; Parathyroids and Secretion and Metabolism of Parathyroid Hormone; Assay of PTH; Parathyroid Hormone Action; References; Chapter 6. Phosphate Homeostasis Regulatory Mechanisms; Introduction; Physiological Aspects; Cellular and Molecular Aspects; Pathophysiological Aspects; References; Chapter 7. Vitamin D Biology; Metabolic Activation of Vitamin D; Mechanism of Action; Role of Vitamin D in Calcium Homeostasis; Summary and Perspectives; References
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Chapter 8. Other Factors Controlling Bone Growth and Development: Calcitonin, CGRP, Osteostatin, Amylin, and AdrenomedullinIntroduction; Calcitonin; Calcitonin Gene-Related Peptide; Parathyroid Hormone-Related Protein; Amylin; Adrenomedullin; References; Chapter 9. Peak Bone Mass and Its Regulation; Definition and Importance of Peak Bone Mass; Characteristics of Peak Bone Mass Acquisition; Calcium-Phosphate Metabolism During Growth; Determinants of Bone Mass Gain; Conclusions; References; Chapter 10. Pregnancy and Lactation; Introduction; Mineral Fluxes from Mother to Offspring; Pregnancy
,
Lactation
,
English
Additional Edition:
ISBN 0-12-286551-0
Language:
English
