UID:
almahu_9949697870002882
Format:
1 online resource (381 p.)
ISBN:
1-281-03824-5
,
9786611038243
,
0-08-053414-7
Series Statement:
Hormones and Signaling
Content:
Hormones and Signaling focuses on the mechanism of gene regulation at the cellular level. It also covers the way hormones act to modulate gene regulation and animal development.Key Features* Includes information on:* Nuclear receptors, coactivators, and corepressors* Membrane receptors, kinases, and phosphorylation on cascades* Hormonal regulation of development* Calcium channels and neurotransmitters* Chromatin, transcription factors, and regulation of gene expression* JAK/STAT pathways* Hormone-regulated development and gene ""knock-out""
Note:
Description based upon print version of record.
,
Front Cover; Hormones and Signaling; Copyright Page; Contents; Contributors; Preface; Chapter 1. Glucocorticoids and Oxysterols in Lymphoid Apoptosis; I. Introduction; II. Mechanisms of Action of the Glucocorticoid Receptor; III. Actions of Oxysterols on Lymphoid Cells; IV. Apoptosis; V. Glucocorticoids and Oxysterols Cause Apoptosis of CEM Cells; VI. Conclusions; References; Chapter 2. RAGE: A Receptor with a Taste for Multiple Ligands and Varied Pathophysiologic States; I. Introduction; II. Identification and Characterization of RAGE
,
III. Expression and Functions of RAGE: Endothelial Cells and Mononuclear PhagocytesIV. RAGE and Diabetes; V. RAGE and Amphoterin; VI. RAGE and Alzheimer's Disease; VII. Hypothesis; References; Chapter 3. The Function and Regulation of the G-Protein-Coupled Receptor Kinases; I. Introduction; II. The Regulation of Cellular Signaling; III. The G-Protein-Coupled Receptor Kinases; IV. The Regulation of the G-Protein-Coupled Receptor Kinases; V. Kinase Enzymology; VI. Receptor-Kinase Specificity; VII. Animal Models; VIII. Physiological Significance; IX. Conclusions; References
,
Chapter 4. Characteristics and Function of the Novel Estrogen Receptor ßI. Introduction; II. Cloning of ERß cDNA; III. Ligand-Binding Characteristics of ERß Protein; IV. Transactivation Function of ERß Protein; V. Expression of ERß mRNA; VI. Physiological Role of ER/3 Protein; VII. Concluding Remarks; References; Chapter 5. EGF Family Receptors and Their Ligands in Human Cancer; I. Introduction; II. EGF Family Receptors; III. EGF-like Growth Factors; IV. Activation of EGF Family Receptors; V. Clinical Significance of EGF Family Receptors
,
VI. Potential Clinical Application by Targeting of EGF Family Receptor Members and LigandsVII. Conclusion; References; Chapter 6. Fertilization: Common Molecular Signaling Pathways across the Species; I. Introduction; II. Oviductal Transport; III. Motility Modulation; IV. Gamete Adhesion; V. Acrosome Reaction; VI. Egg Plasma Membrane Interactions and Egg Activation; References; Chapter 7. The JNK Family of MAP Kinases: Regulation and Function; I. Introduction; II. Regulation of c-Jun Expression and Activity; III. Phosphorylation of the c-Jun Amino-Terminal Sites by JNK
,
IV. Signal Transduction Pathways Leading to Activation of JNK and Other MAP KinasesV. Other Substrates for the JNKs; VI. Biological Functions of JNK and Other MAP Kinase Pathways; VII. Conclusions and Future Considerations; References; Chapter 8. PPARa: Tempting Fate with Fat; I. PPARa as a Ligand-Activated Transcription Factor; II. Lipid Homeostasis: How Complex Can It Be?; III. PPARa Expression during Development and Adulthood; IV. PPARa and Its Activators: Open Relationships?; V. PPARa Ligands; VI. PPARa Functions; VII. Conclusion; References
,
Chapter 9. Molecular Mechanisms of Neuronal Survival and Apoptosis
,
English
Additional Edition:
ISBN 0-12-312411-5
Language:
English
