UID:
almahu_9949698026902882
Format:
1 online resource (1119 p.)
ISBN:
0-12-386883-1
Content:
Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The chapters are written by international experts to allow readers from a wide variety of backgrounds, clinical and non-clinical (basic geneticists, pharmacologists, clinicians, trialists, industry personnel, ethicists) to understand th
Note:
Description based upon print version of record.
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Half title; Title Page; Copyright; Dedication; Contents; Contributors; Foreword; Preface; Acknowledgements; Part I: Introduction; 1 Pharmacogenomics and Stratified Medicine; 1.1 Overview; 1.2 The Genetic Basis of Drug Response and Adverse Effects; 1.3 Single-Gene Studies; 1.3.1 Predicting Efficacy; 1.3.2 Predicting Drug Dosage; 1.3.3 Predicting Drug Toxicity; 1.4 Genome-Wide Association Studies in Pharmacogenomics; 1.5 The Road to Personalization and Stratification; 1.6 Pharmacogenetic Biomarkers and Companion Diagnostics; 1.6.1 Evaluating Pharmacogenomic Biomarkers/CDx for Clinical Use
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1.7 Economic Challenges1.8 Conclusions; References; Part II: Basic Genetics; 2 Basic Genetics: The Cell, Mitosis and Meiosis, and Mendelian Laws; 2.1 Overview of the Cell: Anatomy, Components, and Function; 2.1.1 Nucleus and Chromosomes; 2.1.2 Membrane-Bound Organelles in Eukaryotic Cells; 2.1.3 Nonmembranous Organelles in Eukaryotic Cells; 2.2 Cell Reproduction: Cell Cycle and Mitosis; 2.3 Meiosis; 2.3.1 Genetic Variation Introduced by Meiosis: The Mechanisms; 2.4 Mendelian Laws; 2.4.1 The Law of Segregation; 2.4.2 The Law of Independent Assortment
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2.4.3 Mendelian Patterns of Inheritance in Humans2.5 Public Databases for Biomedical Research in Humans; 2.6 Conclusion; Glossary; Acknowledgments; References; 3 The Human Genome, Gene Regulation, and Genomic Variation; 3.1 Overview: Structure of the Human Genome; 3.1.1 Chromatin Structure; 3.1.2 The Nucleosome; 3.2 Gene Structures; 3.2.1 Number of Genes; 3.3 Gene Expression; 3.3.1 Transcription; 3.3.2 Translation; 3.4 Gene Regulation; 3.4.1 Gene Regulation by miRNAs; 3.4.2 mRNA Targets; 3.4.2.1 Mechanisms of Silencing; 3.4.3 Chromatin Modifications and Gene Expression
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3.4.4 Nucleosome Positioning and Occupancy3.5 Genomic Variation; 3.5.1 Single-Nucleotide Polymorphisms; 3.5.1.1 Effect of SNPs on Gene Expression; 3.5.1.2 Linkage and Haplotype Blocks; 3.5.2 Copy Number Variants; 3.5.2.1 Mechanisms of CNV Formation; 3.5.2.2 Population Genetics of CNVs; 3.5.2.3 Relationship of CNVs and Transcriptional Regulation; 3.5.3 The ENCODE Project and the Characterization of Human Variants; 3.6 Conclusion; References; 4 Epigenetics; 4.1 Overview; 4.2 DNA Methylation; 4.2.1 Effects of DNA Methylation; 4.2.2 DNA Methyltransferases
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4.2.3 Techniques for Measuring Methylation4.3 Histones and Variants; 4.3.1 Histone PTMs; 4.3.2 Histone PTM Effects; 4.3.3 Techniques for Measuring Histones and Other Chromatin-Interacting Proteins; 4.4 Epigenetic Disorders And Therapies; 4.5 Conclusion; References; Part III: Experimental and Discovery Platforms; 5 Animal Models in Pharmacogenomics; 5.1 Overview; 5.2 Rodent Models; 5.2.1 Mouse Models; 5.2.2 Rat Models; 5.2.3 Outbred Rodent Stocks; 5.2.4 Inbred Strains; 5.2.5 Heterogeneous Stocks; 5.2.6 Collaborative Cross; 5.2.7 Recombinant Inbred Strains; 5.2.8 Congenic Strains
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5.2.9 Consomic Strains
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English
Additional Edition:
ISBN 0-12-386882-3
Language:
English
