UID:
almahu_9949698051902882
Format:
1 online resource (427 p.)
ISBN:
1-281-05445-3
,
9786611054458
,
0-08-054350-2
Series Statement:
Biology of extracellular matrix series
Content:
In the last several years, the development of reagents that recognize smooth muscle-specific proteins has enabled researchers to identify smooth muscle cells (SMC) in tissue undergoing both differentiation and repair. These developments have led to increased research on SMC. The latest volume in the Biology of the Extracellular Matrix Series takes a current and all-encompassing look at this growing area of research. Devoted entirely to the subject of SMC, the book covers a diversity of topics-from SMC architecture and contractility to differentiation and gene expression in development. It also
Note:
Description based upon print version of record.
,
Front Cover; THE VASCULAR SMOOTH MUSCLE CELL: Molecular and Biological Responses to the Extracellular Matrix; Copyright Page; Contents; Contributors; Preface; Chapter 1. Development of the Vessel Wall: Overview; I. Differentiation, Dedifferentiation, and Phenotypic Modulation of Smooth Muscle Cells; II. Phenotypic Changes in Vascular Smooth Muscle Cells in Culture; III. Reversibility of Smooth Muscle Phenotypic Change; IV. Does Change in Phenotype Imply Replication?; V. Why Do the Majority of Contractile Smooth Muscle Cells Undergo a Change in Phenotype prior to Mitosis?
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VI. Cells with an Undifferentiated Appearance in Mature Blood VesselsVII. Origin of Intimal Smooth Muscle Cells; VIII. Conclusions; IX. Questions Which Need to Be Answered; References; Chapter 2. Smooth Muscle Cell Differentiation during Early Development and during Intimal Thickening Formation in the Ductus Arteriosus; I. Introduction; II. Regulation of Smooth Muscle Cell Differentiation and Analogies to Skeletal Muscle; III. Smooth Muscle a-Actin Expression during Early Development; IV. Development of the Tunica Media of the Vascular Wall; V. Smooth Muscle Development and Neural Crest Cells
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VI. Smooth Muscle Cells of the Ductus ArteriosusVII. Regulation of Smooth Muscle Cell Function Exemplified in the Ductus Arteriosus; VIII. Conclusions; References; Chapter 3. Integrins, Cytoskeletal and Extracellular Matrix Proteins in Developing Smooth Muscle Cells of Human Aorta; I. Introduction; II. Development of Human Aorta; III. Developmental Changes in Expression of Cytoskeletal and Contractile Proteins; IV. Changes in Expression of Extracellular Matrix Proteins in Development; V. Integrins in Developing Smooth Muscle
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VI. Different Stages of Smooth Muscle Development: Phenotopic Transitions and Heterogeneity of the Smooth Muscle Cells from Human AortaVII. The Dense Plaque as a Smooth Muscle-Specific Structure Involved in Linkgages between Extracellular Matrix and Cytoskeleton; VIII. Smooth Muscle Development and Alternative Pre-mRNA Splicing; IX. Conclusions; References; Chapter 4. Relevance of Smooth Muscle Replication and Development to Vascular Disease; I. History; II. Identity of the Intimal Cell; III. Neointimal Formation: A Generic Response of Vessels to Injury?
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IV. Pharmacology of Neointimal FormationV. Specific Molecules in the Rat Model; VI. The Role of Intimal Replication in the Formation of an Atherosclerotic Lesion; VII. How Does the Intima Contribute to Atheroschlerosis?; VIII. Intimal Cells Overexpress Certain Genes in Vitro as Well as in Vivo; IX. Plaque-Specific Gene Expression by Smooth Muscle Cells; X. Mechanism of Lumen Occlusion in Atherosclerosis; XI. The Nature of Restenosis Following Angioplasty; XII. Future Directions; References; Chapter 5. Smooth Muscle Gene Expression during Developmental Maturation; I. Introduction
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II. Mammalian Prenatal Blood Vessel Development
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English
Additional Edition:
ISBN 0-12-632310-0
Language:
English
