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Format: 1 online resource (563 pages)

Edition: 2nd ed.

ISBN: 9780128245521 , 0-12-824553-0

Content: 3D Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine, Second Edition provides an in-depth introduction to bioprinting and nanotechnology and their industrial applications. Sections cover 4D Printing Smart Multi-responsive Structure, Cells for Bioprinting, 4D Printing Biomaterials, 3D/4D printing functional biomedical devices, 3D Printing for Cardiac and Heart Regeneration, Integrating 3D printing with Ultrasound for Musculoskeletal Regeneration, 3D Printing for Liver Regeneration, 3D Printing for Cancer Studies, 4D Printing Soft Bio-robots, Clinical Translation and Future Directions.

Note: Front Cover -- 3D Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine -- Copyright Page -- Contents -- List of contributors -- Preface -- I. Principles -- 1 Nanotechnology: A Toolkit for Cell Behavior -- 1.1 INTRODUCTION -- 1.2 NANOBIOMATERIALS FOR TISSUE REGENERATION -- 1.2.1 CARBON NANOBIOMATERIALS -- 1.2.1.1 Carbon Nanotubes -- 1.2.1.2 Carbon Nanofibers -- 1.2.1.3 Graphene -- 1.2.2 SELF-ASSEMBLING NANOBIOMATERIALS -- 1.2.2.1 Self-Assembling Nanotubes -- 1.2.2.2 Self-Assembling Nanofibers -- 1.2.3 POLYMERIC AND CERAMIC NANOBIOMATERIALS -- 1.2.3.1 Polymeric Nanobiomaterials -- 1.2.3.2 Ceramic Nanobiomaterials and Ceramic-Polymer Nanocomposites -- 1.3 3D NANO/MICROFABRICATION TECHNOLOGY FOR TISSUE REGENERATION -- 1.3.1 3D NANOFIBROUS AND NANOPOROUS SCAFFOLDS FOR TISSUE REGENERATION -- 1.3.1.1 Electrospun Nanofibrous Scaffolds for Tissue Regeneration -- 1.3.1.2 Other 3D Nanofibrous/Nanoporous Scaffolds for Tissue Regeneration -- 1.3.2 3D PRINTING OF NANOMATERIAL SCAFFOLDS FOR TISSUE REGENERATION -- 1.3.2.1 3D Printing Techniques for Tissue Regeneration -- 1.3.2.2 3D Printing of Nanomaterial Scaffolds for Tissue Regeneration -- 1.4 CONCLUSION AND FUTURE DIRECTIONS -- Acknowledgments -- Questions -- References -- 2 Bioprinting of Biomimetic Tissue Models for Disease Modeling and Drug Screening -- 2.1 Introduction -- 2.2 Current 3D Bioprinting Approaches to Build Biomimetic Tissue Models -- 2.2.1 Current 3D Bioprinting Technology -- 2.2.1.1 Inkjet-Based Bioprinting -- 2.2.1.2 Extrusion-Based Bioprinting -- 2.2.1.3 Light-Based Bioprinting -- 2.2.1.3.1 TPP-Based Bioprinting -- 2.2.1.3.2 DLP-Based Bioprinting -- 2.2.2 Cell Source and Preparation -- 2.2.3 Biomaterial Choice -- 2.3 Drug Screening and Disease Modeling Applications in Various Organs -- 2.3.1 Liver Models -- 2.3.2 Cardiac and Skeletal Muscle Models. , 2.3.2.1 Cardiac Muscle -- 2.3.2.2 Skeletal Muscle Models -- 2.3.3 Cancer Models -- 2.4 Challenges and Future Outlook -- Acknowledgments -- Declaration of Interests -- References -- 3 3D BIOPRINTING TECHNIQUES -- 3.1 Introduction -- 3.2 Definition and Principles of 3D Bioprinting -- 3.3 3D Bioprinting Technologies -- 3.3.1 Ink-Jet-Based Bioprinting -- 3.3.2 Pressure-Assisted Bioprinting -- 3.3.3 Laser-Assisted Bioprinting -- 3.3.4 Solenoid Valve-Based Printing -- 3.3.5 Acoustic-Jet Printing -- 3.4 Challenges and Future Development of 3D Bioprinting -- 3.5 Conclusion -- References -- 4 The Power of CAD/CAM Laser Bioprinting at the Single-Cell Level: Evolution of Printing -- 4.1 Introduction -- 4.1.1 Direct Contact Versus Direct Write for Single-Cell Printing -- 4.2 Basics of Laser-Assisted Printing: Overview of Systems and Critical Ancillary Materials -- 4.2.1 Laser-Assisted Cell Transfer System Components -- 4.2.2 Absorbing Film-Assisted Laser-Induced Forward Transfer -- 4.2.3 Matrix-Assisted Pulsed-Laser Evaporation Direct Write -- 4.2.4 Ancillary Materials -- 4.3 Matrix-Assisted Pulsed-Laser Evaporation Direct-Write Mechanistics -- 4.3.1 Modeling Cellular Droplet Formation -- 4.3.1.1 Modeling Bubble Formation-Induced Process Information -- 4.3.1.2 Modeling Laser-Matter Interaction Induced Thermoelastic Stress -- 4.3.2 Modeling of Droplet Landing Process -- 4.4 Postprocessing Cell Viability and Function -- 4.5 Case Studies and Applications Illustrating the Importance of Single-Cell Deposition -- 4.5.1 Isolated-Node, Single-Cell Arrays -- 4.5.2 Network-Level, Single-Cell Arrays -- 4.5.3 Next-Generation Single-Cell Arrays: Integrated, Computation-Driven Analysis -- 4.5.4 Example of Single-Cell Array via Matrix-Assisted Pulsed-Laser Evaporation Direct Write -- 4.5.5 Laser Direct Write for Neurons -- 4.5.5.1 Neural Development. , 4.5.5.2 Engineered Circuits -- 4.5.5.3 Nonneuronal Interactions -- 4.5.5.4 Outlook -- 4.6 Conclusion -- References -- 5 Laser Direct-Write Bioprinting: A Powerful Tool for Engineering Cellular Microenvironments -- 5.1 Introduction -- 5.1.1 Spatial Influences of the Cellular Microenvironment -- 5.1.2 Overview of Printing Techniques for Engineering Cellular Microenvironments -- 5.1.3 Laser Direct-Write Overview -- 5.2 Materials in Laser Direct-Write -- 5.2.1 Material Properties Influencing Cellular Microenvironments -- 5.2.2 Matrigel-Based Laser Direct-Write -- 5.2.3 Gelatin-Based Laser Direct-Write -- 5.2.4 Dynamic Release Layers -- 5.2.5 Additional Hydrogels Used for Printing and the Receiving Substrate -- 5.2.6 Nonhydrogel Receiving Substrates and Synergistic Technologies -- 5.3 Laser Direct-Write Applications in 2D -- 5.4 Laser Direct-Write Applications in 3D -- 5.4.1 Microenvironments in 3D -- 5.4.2 Layer-By-Layer Approaches -- 5.4.3 Laser Direct-Write Microbeads -- 5.4.4 Fabrication of Core-Shelled Microenvironments -- 5.5 Conclusions and Future Directions -- Acknowledgments -- Questions -- References -- 6 Bioink Printability Methodologies for Cell-Based Extrusion Bioprinting -- 6.1 Introduction -- 6.2 Definition of Printability -- 6.2.1 Consideration on Novel Bioink Development -- 6.2.2 Measures of Printability -- 6.3 Relationships Between Printing Outcomes and Rheological Properties -- 6.3.1 Extrudability -- 6.3.2 Filament Classification -- 6.3.3 Shape Fidelity -- 6.3.4 Impact of Cell Density on Printing Outcomes -- 6.4 Relationships Between Printing Outcomes and Process Parameters -- 6.4.1 Process Parameters -- 6.4.2 Improving Printability by Process Parameters -- 6.5 Models for Printability -- 6.6 Current Limitations -- 6.7 Conclusion -- Acknowledgments -- Questions -- References -- 7 Hydrogels for Bioprinting -- 7.1 Hydrogels in Bioprinting. , 7.1.1 Natural Hydrogel -- 7.1.1.1 Collagen -- 7.1.1.2 Gelatin -- 7.1.1.3 Fibrin -- 7.1.1.4 Alginate -- 7.1.1.5 Chitosan and Chitin -- 7.1.1.6 Hyaluronic Acid -- 7.1.1.7 Decellularized Extracellular Matrix -- 7.1.2 Synthetic Hydrogel -- 7.1.2.1 Poly(2-Hydroxyethyl Methacrylate) -- 7.1.2.2 Poly(vinyl alcohol) -- 7.1.2.3 Poly(ethylene glycol) -- 7.1.2.4 Poly(lactic acid) -- 7.1.2.5 Poloxamers -- 7.1.3 Bioinspired Synthetic Hydrogel -- 7.2 Considerations for Using Hydrogel in Bioprinting -- 7.2.1 General Consideration -- 7.2.1.1 Biocompatibility -- 7.2.1.2 Water Content -- 7.2.1.3 Swelling Behavior -- 7.2.1.4 Solute Transportation -- 7.2.1.5 Degradation -- 7.2.2 Technology Specific Consideration -- 7.2.2.1 Material Extrusion -- 7.2.2.1.1 Material Consideration -- 7.2.2.1.2 Process Consideration -- 7.2.2.2 Material Jetting -- 7.2.2.2.1 Material Consideration -- 7.2.2.2.2 Process Consideration -- 7.2.2.3 Vat Polymerization -- 7.2.2.3.1 Material Consideration -- 7.2.2.3.2 Process Consideration -- 7.3 Strategies Used in Hydrogel-Based Bioprinting -- 7.3.1 Tuning Rheology of Bioink -- 7.3.2 Inducing Crosslinking during Bioprinting -- 7.3.3 Crosslinking after Bioprinting -- 7.3.4 Bioprinting with Support -- 7.3.5 Hybrid Bioprinting -- 7.4 Perspective and Outlook -- References -- 8 4D Printing: 3D Printing of Responsive and Programmable Materials -- 8.1 INTRODUCTION -- 8.2 RESPONSIVE AND PROGRAMMABLE MATERIALS FOR 4D PRINTING -- 8.2.1 SHAPE-MEMORY POLYMERS -- 8.2.2 RESPONSIVE SHAPE-CHANGING POLYMERS AND THEIR COMPOSITES -- 8.3 REALIZATION OF 4D PRINTING -- 8.3.1 4D PRINTING BASED ON FUSION DEPOSITION MODELING -- 8.3.2 4D PRINTING BY DIRECT INK WRITING -- 8.3.3 4D PRINTING BY PHOTOPOLYMERIZATION -- 8.4 APPLICATIONS OF 4D PRINTING -- 8.4.1 BIOMEDICAL APPLICATIONS -- 8.4.1.1 Tissue Engineering -- 8.4.1.2 Implantable Devices -- 8.4.2 SOFT ROBOTS. , 8.4.3 FLEXIBLE ELECTRONICS -- 8.4.4 FOOD PROCESSING -- 8.5 CONCLUSION AND PROSPECTIVE -- QUESTIONS -- References -- II. Applications: Nanotechnology and 3D Bioprinting for Tissue/Organ Regeneration -- 9 Blood Vessel Regeneration -- 9.1 Introduction -- 9.1.1 Additive Manufacturing -- 9.1.2 Important Proteins for Vasculature -- 9.1.3 Application to Vascular Implants -- 9.2 Cell-Free Scaffolds -- 9.2.1 Electrospinning -- 9.2.2 Stereolithography -- 9.2.3 Fused-Deposition Modeling -- 9.3 Cell-Based Scaffolds -- 9.3.1 Inkjet Printing -- 9.3.2 Extrusion-Based Bioprinting -- 9.3.2.1 Coaxial Printing -- 9.3.3 Laser-Assisted Printing -- 9.4 Comparison of the Technologies -- 9.4.1 Applications to the Vascular System and Other Tissue-Engineered Implants -- 9.5 Future Directions -- Acknowledgments -- References -- 10 3D PRINTING AND PATTERNING VASCULATURE IN ENGINEERED TISSUES -- 10.1 Introduction -- 10.1.1 Macroporous Constructs as Tissue Templates -- 10.1.2 Fabricating Fluidic Networks within Biomaterials -- 10.1.3 Approaches to Fabricate Endothelialized and Cell-Laden Tissue Constructs -- 10.1.4 Approaches to Integrate Patterned Vasculature In Vivo -- 10.1.5 Patterning Multiscale Vasculature with Endothelial Function -- 10.1.6 Angiogenesis, Vasculogenesis, and In Vivo Integration -- 10.1.7 Advanced Technologies which May Assist in Vascular Tissue Fabrication -- References -- 11 Craniofacial and Dental Tissue -- 11.1 Introduction -- 11.2 Clinical Need for Craniofacial and Dental Regenerative Medicine -- 11.2.1 Major Diagnoses and Causes -- 11.2.1.1 Dental Disease -- 11.2.1.2 Trauma -- 11.2.1.3 Aging -- 11.2.1.4 Cancer -- 11.2.1.5 Congenital -- 11.2.2 Standard-of-Care Procedures -- 11.2.2.1 Teeth -- 11.2.2.2 Bone and Cartilage -- 11.2.2.3 Soft Tissue -- 11.3 Craniofacial and Dental Regenerative Medicine Research -- 11.3.1 Novel Materials -- 11.3.2 Teeth. , 11.3.3 Bone.

Additional Edition: Print version: Zhang, Lijie Grace 3D Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine San Diego : Elsevier Science & Technology,c2022

Language: English