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Format: 1 online resource (406 pages)

Edition: First edition.

ISBN: 9780323901451

Note: Front Cover -- Microbes, Microbial Metabolism, and Mucosal Immunity -- Copyright Page -- Dedication -- Contents -- List of contributors -- About the editor -- About the authors -- Preface -- Acknowledgments -- 1 Intestinal barrier immunity: key players in the gut microbial "meet and greet or get-rid" event -- 1.1 Barrier maintenance -- 1.1.1 Barrier sites: the venues for microbial meet and greet events -- 1.1.2 Barrier immunity at the intestinal mucosa -- 1.2 Physical and chemical barriers -- 1.2.1 Anatomical barriers -- 1.2.2 Chemical barriers -- 1.3 Immune surveillance-the ultimate biological barrier -- 1.3.1 Immune surveillance by innate immune cells -- 1.3.1.1 Granulocytes: neutrophils, eosinophils, basophils and mast cells -- 1.3.1.2 Dendritic cells -- 1.3.1.3 Monocytes and macrophages -- 1.3.1.4 NK cells -- 1.4 Immune surveillance by the adaptive immune system -- 1.4.1 B lymphocytes in barrier immunity -- 1.4.2 Role of T cells in barrier immunity -- 1.5 Conventional T cells in intestinal immunity -- 1.6 The role of unconventional T cells in intestinal immunity -- 1.7 Dysregulation of barrier immunity -- 1.8 Conclusion -- Abbreviations -- References -- Further readings -- 2 Gut-brain communication through microbes -- 2.1 Introduction -- 2.2 Metabolic and endocrine signaling pathways -- 2.2.1 Short-chain fatty acids -- 2.2.2 Gut hormones -- 2.3 Neuroactive molecules -- 2.4 γ-aminobutyric acid -- 2.4.1 Dopamine and its metabolites -- 2.4.2 Tryptophan metabolism and serotonin -- 2.5 Neural signaling-the vagus nerve -- 2.6 The hypothalamic-pituitary adrenal axis -- 2.7 Immune signaling and immune system activation -- 2.8 Impacts of the microbiome on central nervous system biology -- 2.8.1 Blood-brain barrier -- 2.8.2 Neurons and glia -- 2.9 Conclusions and future directions -- Abbreviation -- References. , 3 Role of gut microbes in shaping neonatal immunity and beyond -- 3.1 Introduction -- 3.2 Prenatal and postnatal establishment of microbiome -- 3.2.1 Changes in the maternal gut microbiome during pregnancy -- 3.2.2 Gut microbiome and pregnancy: a bi-directional relationship -- 3.2.3 Microbial colonization and immune education in utero -- 3.2.4 Gut microbiota and early life development -- 3.2.5 Impact of diet and the microbiota on immune system development in early life -- 3.2.6 Opportunities for intervention -- 3.2.7 Role of microbial metabolites in shaping neonatal immunity -- 3.2.8 It all starts inside: in utero microbial stimulation -- 3.2.9 Neonatal gut microenvironment -- 3.2.10 Microbial metabolites and associated diseases -- 3.2.11 Role of neonatal microbiome in shaping innate immune memory -- 3.2.12 Trained immunity in shaping the neonatal immune development -- 3.2.13 Effect of prenatal vaccination on shaping neonatal immunity -- 3.2.14 Immune protection through the maternal antibodies -- 3.2.15 Maternal immune system during pregnancy -- 3.2.16 Maternal-fetal interface -- 3.2.17 Implications for pregnancy outcomes -- 3.3 Prenatal vaccination and protection against specific pathogens -- 3.3.1 Tetanus, diphtheria, and pertussis -- 3.3.2 Influenza virus -- 3.3.3 Maternal vaccines in development -- 3.3.4 Respiratory syncytial virus vaccine -- 3.3.5 Group B streptococcus vaccine -- 3.3.6 Cytomegalovirus vaccine -- 3.4 Streptococcus pneumoniae vaccine -- 3.5 Group A Streptococcus vaccine -- 3.6 Conclusions -- Abbreviation -- References -- 4 Respiratory microbiome -- 4.1 Respiratory microbiome during development and homeostasis -- 4.2 Respiratory mycobiome and virome -- 4.3 Microbiota dysbiosis in respiratory diseases -- 4.4 Methods for the sampling and assessment of the respiratory microbiome. , 4.5 Immunomodulatory role of lung microbiome in mammalian hosts -- 4.6 Therapeutic implications of the lung microbiome -- 4.7 Concluding remarks -- Abbreviations -- References -- 5 Oral immune system and microbes -- 5.1 Introduction -- 5.2 The oral microbiome -- 5.2.1 Core oral microbiome -- 5.2.2 Composition in different ecological niches -- 5.2.2.1 Salivary microbiome -- 5.2.2.2 Dental plaque microbiome -- 5.2.2.3 Soft tissue microbiome -- 5.2.3 Acquisition and development of oral microbiome -- 5.3 The oral immune system -- 5.3.1 Oral innate immunity -- 5.3.1.1 Oral mucosal epithelial cells -- 5.3.1.2 Oral antimicrobial peptides -- 5.3.1.3 Oral complement system -- 5.3.1.4 Oral mucosal innate immune cells -- 5.3.1.5 Saliva -- 5.3.2 Oral adaptive immunity -- 5.3.2.1 B Lymphocytes and humoral response -- 5.3.2.2 Lymphocytes T and cytokines -- 5.3.3 Oral mucosa -- 5.3.4 Gingiva, gingival sulcus and gingival crevicular fluid -- 5.4 Factors influencing the oral microbiome and the host immunity -- 5.4.1 Age -- 5.4.2 Intrinsic factors -- 5.4.3 Extrinsic factors -- 5.5 Oral microbiome and host immunity in health -- 5.6 Oral microbiome and host immunity dysbiosis in diseases -- 5.6.1 Dysbiosis in periodontitis and inflammation -- 5.6.2 Dysbiosis in caries and diet -- 5.7 Conclusions -- Acknowledgments -- Abbreviations -- References -- 6 The eye and the microbiome -- 6.1 Introduction -- 6.1.1 The "healthy" gut microbiome -- 6.1.2 The "healthy" ocular surface microbiome -- 6.1.2.1 Human studies -- 6.1.2.2 Animal studies -- 6.2 Relationships between gut and ocular surface microbiome composition and eye disease -- 6.2.1 The microbiome and Sjögren's -- 6.2.1.1 Human studies, gut microbiome -- 6.2.1.2 Human studies, other microbiomes -- 6.2.1.3 Animal models -- 6.2.1.4 Summary -- 6.2.2 The microbiome and glaucoma -- 6.2.2.1 Human studies, gut microbiome. , 6.2.2.2 Human studies, other microbiomes -- 6.2.2.3 Animal models -- 6.2.2.4 Summary -- 6.2.3 The microbiome and uveitis -- 6.2.3.1 Human studies, gut microbiome -- 6.2.3.2 Animal models -- 6.2.3.3 Summary -- 6.2.4 The microbiome and age-related macular degeneration -- 6.2.4.1 Human studies, gut microbiome -- 6.2.4.2 Human studies, other microbiomes -- 6.2.4.3 Animal models -- 6.2.4.4 Summary -- 6.2.5 The microbiome and diabetic retinopathy -- 6.2.5.1 Human studies, gut microbiome -- 6.2.5.2 Animal models -- 6.2.5.3 Summary -- 6.2.6 The microbiome and endophthalmitis -- 6.2.6.1 Human studies, other microbiomes -- 6.3 Conclusion -- Financial support -- Conflict of interest -- Abbreviations -- References -- 7 Commensal virome and mycobiome -- 7.1 Introduction -- 7.2 Characterization of the virome and the mycobiome -- 7.3 Specific strategies for studying the virome -- 7.4 Specific strategies for studying the mycobiome -- 7.5 Distribution of the virome and mycobiome in the human body -- 7.5.1 Compartment-specific viromes -- 7.5.2 The gastrointestinal virome -- 7.5.3 The oral and respiratory tract virome -- 7.5.4 The skin virome -- 7.5.5 The genitourinary tract virome -- 7.5.6 The blood virome -- 7.5.7 Compartment-specific mycobiomes -- 7.5.8 The gastrointestinal mycobiome -- 7.5.9 The oral and respiratory mycobiome -- 7.5.10 The skin mycobiome -- 7.5.11 The genitourinary tract mycobiome -- 7.6 Virome and mycobiome acquisition and development -- 7.7 Trans-kingdom interactions -- 7.8 Conclusions and future directions -- Abbreviations -- References -- 8 Microbiome and the COVID-19 pandemic -- 8.1 Introduction -- 8.2 Microbiome characteristics in COVID-19 -- 8.3 Intestinal microbiome -- 8.4 Upper respiratory tract microbiome -- 8.5 Lower respiratory tract microbiome -- 8.6 Oral microbiome -- 8.7 Pediatric microbiome characteristics in COVID-19. , 8.8 Review of analytic methods for COVID-19 microbiome data -- 8.8.1 Technologies -- 8.8.2 Diversity indices -- 8.8.3 Distance measures and visualizations -- 8.8.4 Analytic techniques -- 8.8.5 Discussions on analytic techniques -- 8.9 Microbiome-based prevention and intervention approaches in COVID-19 -- 8.9.1 Probiotics -- 8.9.2 Prebiotics -- 8.9.3 Postbiotics -- 8.9.4 Fecal microbiota transplantation -- 8.10 Conclusion -- Abbreviations -- References -- Author Index -- Subject Index and Keywords -- Back Cover.

Additional Edition: Print version: Bose, Tanima Microbes, Microbial Metabolism and Mucosal Immunity San Diego : Elsevier Science & Technology,c2024 ISBN 9780323901444

Language: English