UID:
almafu_9959627083802883
Format:
1 online resource (XI, 353 p.)
ISBN:
9783110609295
Series Statement:
De Gruyter Textbook
Content:
Life in all its forms is based on nucleic acids which store and transfer genetic information. The book addresses the main aspects of synthesis, hydrolytic stability, solution equilibria of nucleosides and nucleotides as well as base modifications of nucleic acids. The author further describes their structural analogues used as therapeutic drugs, such as antivirals and anticancer agents, and prodrug strategies of nucleotides.
Note:
Frontmatter --
,
Preface --
,
Contents --
,
1 Nucleosides: structure, nomenclature and solution equilibria --
,
2 Nucleosides: synthesis, reactions and use in chemotherapy --
,
3 Nucleotides --
,
4 Oligonucleotides: synthesis --
,
5 Oligonucleotides: reactions of phosphodiester linkages --
,
6 Oligonucleotide conjugates --
,
7 Nucleic acids --
,
8 Catalytic nucleic acids --
,
9 Nucleic acids as drugs and drug targets 1: antisense, splice-switching, triplex-forming and immune-stimulatory oligonucleotides --
,
10 Nucleic acids as drugs and drug targets 2: RNA interference, 2′,5′-oligoadenylates and riboswitches --
,
11 Nucleic acids as drugs and drug targets 3: target recognition and delivery --
,
Abbreviations --
,
Index
,
In English.
Additional Edition:
ISBN 9783110613988
Additional Edition:
ISBN 9783110609271
Language:
English
Subjects:
Chemistry/Pharmacy
,
Biology
Keywords:
Lehrbuch
;
Lehrbuch
DOI:
10.1515/9783110609295
URL:
https://doi.org/10.1515/9783110609295
URL:
https://www.degruyter.com/isbn/9783110609295
URL:
https://doi.org/10.1515/9783110609295
URL:
https://www.degruyter.com/isbn/9783110609295
URL:
Volltext
(URL des Erstveröffentlichers)
URL:
Volltext
(URL des Erstveröffentlichers)
