UID:
edoccha_9958058468602883
Format:
1 online resource (182 p.)
ISBN:
3-318-00228-3
Series Statement:
Frontiers of hormone research ; vol. 23
Content:
Over the past decade, the potential of the pineal hormone melatonin as a therapeutic agent in a variety of diseases has been recognized. This book is the first to review the effect of melatonin in sleep disorders, its possible use as an immunoregulatory agent and clinical results obtained in cancer immunotherapy. Several papers are devoted to the pharmacological and molecular characterization of melatonin receptors in a variety of cell types. Other contributions further investigate the immunoenhancing effect of melatonin, such as in viral encephalitis and bacterial infections, and consider possible therapeutic indications. Melatonin is also reported to exert important hematopoietic effects by stimulating the production of novel T helper cell opioid cytokines. Other basic studies introduce new perspectives describing melatonin as a potent free radical scavenger. This book should be read by clinicians working in the fields of sleep disorders, oncology and infectious diseases as well as by scientists active in the field of neuroimmunomodulation. It will also be very useful to all those interested in melatonin as a therapeutic agent.
Note:
"2nd Locarno Meeting on Neuroendocrinoimmunology, Locarno, May 5-8, 1996."
,
""Contents""; ""Preface""; ""Foreword""; ""The Pars tuberalis � A Pituitary Target for Melatonin""; ""The Nocturnal Melatonin Peak and the Photoperiodic Response""; ""Nuclear Signalling of Melatonin1""; ""Expression ofMembraneMelatonin Receptor mRNA in Rat Thymus and Spleen1""; ""Mechanisms of Action of Melatonin on the Human Immune System1""; ""Melatonin Rhythm in Mice and Its Role in Autoimmune Diseases""; ""New T Helper Cell Opioid Cytokines as Mediators of the Immunological and Hematopoietic Action of Melatonin""; ""The Protective Effect of Melatonin in Viral and Bacterial Infections1""
,
""Cellular and Molecular Actions of Melatonin as an Antioxidant""""Melatonin Reduces the Expression of Excitotoxicity-Triggered Markers of Apoptosis1""; ""Relationship between the Pineal Gland and Experimentally Induced Malignant Tumors""; ""Melatonin Suppression of Tumor Growth in vivo: A Novel Mechanism Involving Inhibition of Fatty Acid Uptake and Metabolism""; ""Modulation of Melatonin Secretion in Cancer Patients""; ""Association of Melatonin with Nuclear Grade and Estrogen Receptor Status in Human Breast Cancer""; ""Melatonin as a Modulator of Cancer Endocrine Therapy""
,
""Presurgical Neuroimmunotherapy with Melatonin and Interleukin-2 in Cancer Patients""""Melatonin � Shutting Off the Wakefulness System""; ""Potential Therapeutic Effects of Melatonin""; ""Subject Index""
,
English
Additional Edition:
ISBN 3-8055-6439-2
Language:
English
