UID:
edoccha_9958130646402883
Format:
1 online resource (various pagings) :
,
illustrations (some color).
ISBN:
1-68174-258-6
,
1-68174-010-9
,
0-7503-2807-X
Series Statement:
[IOP release 2]
Content:
The concept of smart drug delivery vehicles involves designing and preparing a nanostructure (or microstructure) that can be loaded with a cargo, this can be a therapeutic drug, a contrast agent for imaging, or a nucleic acid for gene therapy. The nanocarrier serves to protect the cargo from degradation by enzymes in the body, to enhance the solubility of insoluble drugs, to extend the circulation half-life, and to enhance its penetration and accumulation at the target site. Importantly, smart nanocarriers can be designed to be responsive to a specific stimulus, so that the cargo is only released or activated when desired. In this volume we cover smart nanocarriers that respond to externally applied stimuli that usually involve application of physical energy. This physical energy can be applied from outside the body and can either cause cargo release, or can activate the nanostructure to be cytotoxic, or both. The stimuli covered include light of various wavelengths (ultraviolet, visible or infrared), temperature (increased or decreased), magnetic fields (used to externally manipulate nanostructures and to activate them), ultrasound, and electrical and mechanical forces. Finally we discuss the issue of nanotoxicology and the future scope of the field.
Note:
"Version: 20151101"--Title page verso.
,
"A Morgan & Claypool publication as part of IOP Concise Physics"--Title page verso.
,
Preface -- Acknowledgments -- Author biography -- 1. Introduction
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2. Light-sensitive nanocarriers -- 2.1. Introduction -- 2.2. Photo-sensitive nanoparticle-based carriers -- 2.3. Drug release via electrostatic assembly/disassembly (reversed surface charge) -- 2.4. Chromophore (or photosensitizer)-activated drug release -- 2.5. Photo-thermal-based drug release -- 2.6. Photo-sensitive caging/uncaging based on photolabile protecting groups -- 2.7. Photo-reduction-triggered drug release
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3. Temperature-sensitive nanocarriers -- 3.1. Introduction -- 3.2. LCST/UCST behavior -- 3.3. Thermo-responsive nanocarriers -- 3.4. Modulation of phase transition temperature in thermo-responsive nanoparticles -- 3.5. Sustained drug release by hydrophobic hydrogels -- 3.6. Cancer therapy via thermo-responsive nanocarriers -- 3.7. Temperature-responsive gene delivery systems -- 3.8. Thermo-sensitive co-delivery systems for cancer therapy -- 3.9. Temperature in photothermal-responsive micro/nano-systems
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4. Magnetic-responsive nanocarriers -- 4.1. Introduction -- 4.2. Magnetic-responsive particles for drug delivery -- 4.3. Magnetic-responsive particles for gene delivery
,
5. Ultrasound-responsive nanocarriers -- 5.1. Introduction -- 5.2. Composition and structure of microbubbles -- 5.3. Ultrasound-responsive materials in drug delivery -- 5.4. Ultrasound-responsive materials in gene delivery
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6. Electrical and mechanical-responsive nanocarriers -- 6.1. Introduction -- 6.2. Electric field-sensitive polymers -- 6.3. Mechanical-responsive nanomaterials -- 7. Nanotoxicology and future scope for smart nanoparticles.
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Also available in print.
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Mode of access: World Wide Web.
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System requirements: Adobe Acrobat Reader.
Additional Edition:
Print version: ISBN 9781681741383
Language:
English
DOI:
10.1088/978-1-6817-4202-1
