UID:
almafu_9959076721702883
Umfang:
1 online resource (278 p.)
ISBN:
1-283-15350-5
,
9786613153500
,
3-8055-9168-3
Serie:
Nestle Nutrition workshop series. Pediatric program, v. 64
Inhalt:
Most indigenous microbes occur in the intestinal tract, and their interactions with the host are largely unknown. Current understanding of host-microbe interactions links early microbial contact to the origin of disease, a theory that has its roots in the hygiene hypothesis. Modern life style appears to deprive the infant of conditions that provide adequate anti-inflammatory or tolerogenic stimuli upon antigen encounter. Thus, maturational signals from the environment and the diet are insufficient to adequately shape the immune system. This publication deals with the relationship between the gut microbiota as well as altered pattern of early microbial contact and the origin of human disease. New aspects of the original hygiene hypothesis are discussed in relation to disorders spanning from allergy and autoimmunity to obesity.The results presented suggest that all these disorders may be linked to aberrant antigen absorption and immune responses associated with dysfunction of mucosal defense. Researchers, clinicians and students interested in the interaction of the host with indigenous gut bacteria and the consequences for human health will find this publication of utmost interest.
Anmerkung:
Description based upon print version of record.
,
""Cover""; ""Contents""; ""Preface""; ""Foreword""; ""Contributors""; ""Keynote Talks""; ""A Paradigm for Commensalism: The Role of a Specific Microbial Polysaccharide in Health and Disease""; ""Abstract""; ""Introduction""; ""Characterization of Bacteroides fragilis""; ""Adaptive Immune Responses to Zwitterionic Polysaccharides""; ""Innate Immune Responses to PSA""; ""Commensal Flora and CD4+ T Cells""; ""Commensal Flora and Organogenesis""; ""Th1/Th2 Balance in PSA-Colonized Mice""; ""Microbial Symbiosis and Intestinal Inflammation""; ""The Microbial Flora in Health and Disease""
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""References""""Discussion""; ""The Hygiene Hypothesis: Do We Still Believe in It?""; ""Abstract""; ""Introduction""; ""Immune Regulation in Infancy""; ""The Role of Gut Microbiota""; ""Clinical Aspects of Allergy""; ""Microbial Deficiency Syndromes of Affluence""; ""Concluding Remarks""; ""References""; ""Discussion""; ""References""; ""Development of Normal Tolerance""; ""�ABC� of Mucosal Immunology""; ""Abstract""; ""Innate and Adaptive Immunity""; ""Mucosal Immune Strategies""; ""Secretory Antibodies Reinforce the Epithelial Barrier""; ""Mucosal Tolerance Induction and Abrogation""
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""Innate Decision-Making Directing Adaptive Immunity""""Conclusions""; ""Acknowledgments""; ""References""; ""Unbenannt""; ""References""; ""Innate and Adaptive Immune Pathways to Tolerance""; ""Abstract""; ""Introduction""; ""The Innate Immune Response and the Development of Tolerance""; ""Adaptive Immune Response and Development of Tolerance""; ""Conclusions""; ""References""; ""Discussion""; ""References""; ""Hitting the Mucosal Road in Tolerance Induction""; ""Abstract""; ""Type-I Allergy and Current Treatment Protocols""; ""Animal Models of Type-I Allergy""
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""Mucosal Tolerance Induction with Recombinant Allergens and New Allergen Constructs""""New Adjuvant Systems with Immunomodulatory Properties""; ""Conclusions""; ""References""; ""Discussion""; ""Global View on Nutrition-Related Health Problems in Childhood""; ""Obesity � Extending the Hygiene Hypothesis""; ""Abstract""; ""The Hygiene Hypothesis: The First Extensions""; ""The Microbiota Hypothesis""; ""Gut Microbiota and Obesity""; ""Gut Microbiota and Glucose Metabolism""; ""Extending the Hygiene Hypothesis of Allergy to Western Lifestyle Disease""; ""References""; ""Discussion""
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""References""""Autoimmunity and Diet""; ""Abstract""; ""Introduction""; ""Lessons from IPEX Syndrome""; ""Lessons from Celiac Disease""; ""Acknowledgments""; ""References""; ""Discussion""; ""References""; ""Eosinophilic Esophagitis: Example of an Emerging Allergic Manifestation?""; ""Abstract""; ""Introduction""; ""Definition and Diagnostic Criteria""; ""Pathogenesis""; ""Epidemiology""; ""Clinical Presentation""; ""Complications""; ""Investigations""; ""Differential Diagnosis""; ""Natural History and Prognosis""; ""Treatment""; ""Conclusion and Suggestions for Future Research""
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""References""
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English
Weitere Ausg.:
ISBN 3-8055-9167-5
Sprache:
Englisch
