Kooperativer Bibliotheksverbund

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Format: 1 online resource (550 p.)

Edition: 1st ed.

ISBN: 0-12-800981-0 , 0-12-801184-X

Series Statement: Handbook of behavioral neuroscience ; volume 23

Note: Description based upon print version of record. , Front Cover; MODELING THE PSYCHOPATHOLOGICAL DIMENSIONS OF SCHIZOPHRENIA: FROM MOLECULES TO BEHAVIOR; Copyright; Contents; Contributors; Preface; I - FROM MOLECULES TO BEHAVIOR; Clinical and Pathological Aspects; 1 - Overview of Schizophrenia: Dimensions of Psychopathology; THE INADEQUACY OF DIAGNOSTIC CATEGORIES; PSYCHOPATHOLOGICAL DIMENSIONS-A CHALLENGE TO CATEGORICAL APPROACH TO DIAGNOSIS; THE NEED FOR A PRECISE DIMENSIONAL MODEL; SPECIFICITY TO DISORDER; CHRONOLOGICAL STABILITY OF DIMENSIONS; DIFFERENTIAL ASSOCIATIONS OF DIMENSIONS WITH BIOLOGICAL AND CLINICAL PARAMETERS , CATEGORIES OR DIMENSIONS, OR BOTH?CONCLUSION; References; 2 - A Review of the Epidemiology of Schizophrenia; INTRODUCTION; EVIDENCE FOR ENVIRONMENTAL FACTORS IN SCHIZOPHRENIA; Prenatal Infection; Influenza; Rubella; Herpes Simplex Virus Type 2; Cytokines and Other Inflammatory Biomarkers; Toxoplasma gondii; Maternal Infection and the Pathobiology of Schizophrenia; Prenatal Nutrition; Paternal Age; Cannabis Use; Immigration Status; Birthplace and Residence; Socioeconomic Status; Childhood Abuse; INFECTIONS AFTER BIRTH; GENE-ENVIRONMENT INTERACTION; Intervention and Prevention , FUTURE DIRECTIONSCONCLUSION; References; Animal Models of Psychotic Disorders: Dimensional Approach; 3 - Modeling Dimensions of Psychopathology: Integration with the Epidemiology and Pathobiology of Psychotic Illness; INTRODUCTION; MODELING DIMENSIONS OF PSYCHOPATHOLOGY; MODELING DIMENSIONS OF PSYCHOPATHOLOGY IN THE CONTEXT OF THE EPIDEMIOLOGY OF PSYCHOTIC ILLNESS; MODELING DIMENSIONS OF PSYCHOPATHOLOGY IN THE CONTEXT OF THE PATHOBIOLOGY OF PSYCHOTIC ILLNESS; CONCLUSIONS; Acknowledgments; References; 4 - Modeling the Positive Symptoms of Schizophrenia; INTRODUCTION , DELUSIONS AND HALLUCINATIONSDelusions; Hallucinations; Visual Hallucinations; Auditory Hallucinations; NEUROIMAGING STUDIES ON POSITIVE SYMPTOMS; Brain Structures; Brain Regional Activity and Connectivity; DELUSIONAL AND HALLUCINOGENIC SIGNALING; Dopamine Signaling through Dopamine D2 Receptors; Serotonin Signaling through Serotonin 2A Receptors; Cannabinoid Signaling through CB-1 Receptors; Cholinergic Signaling through Muscarinic Receptors; Gamma-Aminobutyric Acid A Signaling through Gamma-Aminobutyric Acid A Receptors; Glutamate Signaling through NMDAR , METHODS TO INVESTIGATE POSITIVE SYMPTOM-RELATED BEHAVIORS IN ANIMAL MODELSPrepulse Inhibition of Startle Response; Locomotor Activity; Head-Twitch Response; Y-Maze Test and Water-Finding Test; Cued and Contextual Fear Conditioning; CONCLUSION; References; 5 - Animal Models of Psychotic Disorders: Dimensional Approach Modeling Negative Symptoms; INTRODUCTION; MODELING SYMPTOMATOLOGY; MODEL VALIDITY; MODELING TECHNIQUES; MODELING THE NEGATIVE SYMPTOMS; Anhedonia; Avolition; Social Withdrawal; Alogia; Blunted Affect; CONCLUSIONS; References; 6 - Modeling Cognitive Impairment , COGNITIVE DYSFUNCTIONS IN SCHIZOPHRENIA AND MOUSE MODELS , English

Language: English