UID:
edoccha_9961089682002883
Format:
1 online resource (638 pages)
Edition:
1st ed.
ISBN:
0-12-811074-0
,
0-12-811073-2
Content:
"Inflammation and Immunity in Depression: Basic Science and Clinical Applications is the first book to move beyond the established theory of cytokine-induced depression and explore the broader role the immune system plays in this devastating mood disorder. The book fully explores the most recent lines of research into this rapidly advancing field, including alterations of T-cells, the neurobiological implications of neuroinflammation and immune alterations for brain development and function, and the genetic components of neuroinflammation in depression, including the relationships between stress and inflammation that are revealing gene-environment interactions in the disorder."
Note:
Front Cover; Inflammation and Immunity in Depression: Basic Science and Clinical Applications; Copyright; Contents; Contributors; Preface; Chapter 1: Depression-Associated Cellular Components of the Innate and Adaptive Immune System; The Innate Immune System; Role of Neutrophils in Innate Immunity and MDD; Monocytes and MDD; Innate Lymphoid Cells (ILCs) and Natural Killer (NK) Cells; NK Cells and Depression; The Adaptive Immune System and Its Components; Summary; References.
,
Chapter 2: Childhood Microbial Experience, Immunoregulation, Inflammation, and Adult Susceptibility to Psychosocial Stres ...Introduction; Microbial Exposures and Human Evolution; Microbiota; Spores; Environmental Microorganisms; Old Infections; Innate and Adaptive Immune Systems Regulate Microbiota; Innate Immune System and Microbiota; Adaptive Immune System and Microbiota; Mechanisms of Immunoregulation by the Old Friends; Immunoregulation by the Old Infections; Immunoregulation by Organisms From the Natural Environment; Immunoregulation by the Microbiota; Endotoxin Tolerance.
,
Microbial ExosomesLifestyle Changes That Impair Microbe-Induced Immunoregulation and That May Be Associated With Depression; Perinatal and Early-Life Antibiotic Exposure; Animal Experiments; Human Data; Caesarean Delivery; Breast Feeding; Diet; Maternal Obesity; Immigration; Stress; Depression; Chronic Stress-Induced Inflammation in Depression; Proinflammatory Cytokines Induce Depression; Depression is Associated With Autoimmune, Allergic and Inflammatory Bowel Disorders; Antidepressant Effects of Anti-Inflammatory and Immunoregulatory Treatments; Microbiota in Human Depression; Animal Data.
,
Microbial Metabolites and the BrainConclusions; References; Chapter 3: Neuroendocrine Abnormalities in Major Depression: An Insight Into Glucocorticoids, Cytokines, and the Kynureni ...; Introduction; The HPA Axis and Glucocorticoid Abnormalities in Major Depression; Glucocorticoid Resistance; Inflammation and Cytokine Dysregulation in Major Depression; Neuroinflammation; Serotonin-Kynurenine Hypothesis and Neurodegeneration; Summary and Conclusion; Future Directions and Translational Significance; References.
,
Chapter 4: Neurovascular Dysfunction With BBB Hyperpermeability Related to the Pathophysiology of Major Depressive DisorderIntroduction; Neurovascular Dysfunction; Blood-Brain Barrier Unit Hyperpermeability; Theoretical Integration With Oxidative and Neuroinflammatory Mechanisms; Oxidative Stress; Neuroinflammation; Conclusions; References; Further Reading; Chapter 5: The Impact of Inflammation on Brain Function and Behavior in Rodent Models of Affective Disorders; Introduction; Stress, Inflammation and Depressive-Like Behaviors in Rodent Models.
Language:
English
