UID:
almafu_9961426819202883
Format:
1 videorecording (31 min., 35 sec.)
,
003135
Note:
Retrieved April 14, 2024, from https://hstalks.com/bs/1880/.
,
Introduction -- Phosphoinositide 3-kinase (PI3K) signaling -- Class Ia PI3K's mediate growth factor signaling -- Receptor tyrosine kinase signaling pathway -- Logic network -- Loss-of-function mutations in tumor suppressors -- Sporadic mutations -- Drug targets -- Regulation of metabolism by PI3K AKT signaling -- NVP BEZ235 -- Targets of BEZ235 (1) -- Targets of BEZ235 (2) -- Generation of mice with mutant PI3K p110a -- Lung adenocarcinoma requires mutant PI3K -- HIF-1alpha -- Visualizing lung tumors using FDG PET -- mTOR inhibition does not reduce tumor volume -- Will a PI3K inhibitor kill K-Ras driven tumors? -- AKT inhibition does not affect tumor size or activity -- Effects of BEZ235 in K-Ras mutant tumors -- BEZ235 specifically kills PI3K driven tumors -- ARRY 886 -- PI3K with MEK inhibitors eradicates K-Ras tumors -- Blocking the PI3K and MAP Kinase pathways -- Inhibition of S6 kinase in K-Ras tumors -- Summary -- References.
Language:
English
