UID:
almafu_9961427220702883
Format:
1 streaming video file (43 min.) :
,
digital, mono, SWF file, sound, color
,
004305
Content:
Audio-visual presentation : Rates and consequences of hospital acquired infection ; History of antibiotic resistance ; The process of natural selection ; Mutation as a source of resistance ; Lateral gene transfer ; The bacterial ecology of a hospital ; Resistance in the community ; Agricultural use of antibiotics ; Modeling resistance in a hospital ; Antibiotic cycling.
Note:
Retrieved April 7, 2024, from https://hstalks.com/bs/136/.
,
Introduction -- Hospital-acquired infections Pennsylvania -- Hospital-acquired infections USA -- Antibiotic resistance -- Resistance in the intensive care unit -- Playing catch-up ball -- Combating antibiotic resistance -- How evolution works -- Natural selcetion in a nutshell -- Natural selcetion: bacteria -- Transformational vs. variational evolution -- Transformational and variational processes -- Variational evolution: bacteria -- Mutation -- Macrolide antibiotics block protein synthesis -- Single point mutation in green binding region -- Mutation perspective -- More complex mechanisms -- Natural ecology of antibiotics, Fleming -- Antibiotic producers resistant to own product -- Lateral gene transfer -- Lateral gene transfer to Enterococcus -- What is the structure of selection? -- Most resistant strains are commensals -- Extremely high rate of drug use -- Hospital staff act as disease vectors -- High rate of patient turnover -- Resistance in the community -- Agricultural use -- Farm to populace transfer -- How can we intervene? -- A model of a hospital -- Translate model into equations -- Studying the dynamics using numerical solution -- Odds ratios can be misleading -- Antibiotic cycling -- Antibiotic cycling based on ecological principles -- Cycling in a neonatal ICU -- Clinical consequences -- Modeling the efficacy of cycling -- Total resistant infections -- Total resistant infections by cycle length -- Resistance increases with cycle period -- Why doesn't cycling work? Scenario 1 -- Why doesn't cycling work? Scenario 2 -- Mixing creates a more heterogeneous environment -- US infectious disease mortality in the 20th century -- Acknowledgements.
Language:
English
