Kooperativer Bibliotheksverbund

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Format: 1 online resource (1 streaming video file (48 min., 02 sec.)) , 004802

Note: Retrieved April 12, 2024, from https://hstalks.com/bs/1455/. , Introduction -- Talk outline -- Known facts about NK cell development (1993) -- IL-2 and IL-15 receptors -- IL-15 induces human NK cell differentiation -- Factors responsible for NK cells development -- KL/FL ligands and NK cells development (1) -- KL/FL ligands and NK cells development (2) -- SCF, IL-2 and IL-15 in NK cell development -- Human natural killer cell development -- Which CD34 subset develops into a NK cell? -- CD34 receptor expression -- CD34 in peripheral blood and lymph nodes -- NK precursor selectively enriched in lymph nodes -- Site of NK cell development -- NK cells in lymph nodes are CD56 bright cells -- Putative stages of human NK cell differentiation -- NK cell development in human lymphopoiesis -- IL-15 and human NK cell survival -- Adoptive transfer of NK cells -- IL-15 is required for NK cell survival in vivo -- IL-15 and NK cell development and survival -- The IL-15 transgene -- NK cell expansion in IL-15tg mice -- IL-15tg mice clinical signs and findings -- Acute T-NK lymphoblastic leukemia -- NK cell maturation -- NK cell subsets -- The immunoregulatory role of NK cell subsets -- Where does the INF-gamma signal come from? -- Macrophage and NK co-culture: LPS activation (1) -- NK cell-derived IFN-gamma -- Macrophage and NK co-culture: LPS activation (2) -- Bright cells are the primary source of IFN-gamma -- IFN-gamma production in bright and dim cells -- CD56 bright NK cells in the immune response -- Innate immunoregulator, CD56 bright -- Innate cytotoxic effector, CD56 dim -- How do inhibitory NKR work? (1) -- How does KIR work? -- How do Inhibitory NKR work? (2) -- The inhibitory receptors bind to specific epitopes -- Common epitopes that bind to these receptors -- Haplo-mismatch bone marrow transplant (BMT) -- Haplo-mismatch BMT that results in lysis -- Haplo-mismatch BMT that results in no lysis -- Haplo-mismatch BMT - no lysis outcome -- Summary of haplo-mismatch BMT -- KIR mismatch/ no mismatch -- Conclusions -- Summary -- Acknowledgments.

Language: English