UID:
edoccha_9961427399102883
Format:
1 videorecording (27 min., 44 sec.)
,
002744
Content:
Audio-visual presentation : Role of cell cycle progression in retrovirus replication ; Resting T-cells and HIV ; Uncoating and PIC nuclear import ; Preintegration complex (PIC) ; Intracellular transport of PIC ; HIV-1 Vpr vs. HIV-2 Vpx ; HIV-1 Vpr interaction factors ; HIV-2: model system for PIC nuclear import ; Vpx cellular localization ; Ability of Vpx-NLS mutant viruses to infect arrested and dividing U937 cells ; Nuclear localization signal of HIV-2 Vpx ; Vpx interaction with HSP 40 ; Heat shock proteins and viruses ; Over-expression of DNAJB6 causes reduction of Vpx packaging in VLP ; Down regulation of DNAJB6 reduces nuclear import of HIV-2 PIC ; Novel mechanism of Vpx-mediated PIC import.
Note:
Retrieved April 16, 2024, from https://hstalks.com/bs/509/.
,
Introduction -- HIV -- Cell cycle progression and retrovirus replication -- Resting T cells and HIV -- Link between uncoating and PIC nuclear import -- Preintegration complex (PIC) -- Intracellular transport of PICs -- The HIV-1 PIC has multiple components with NLS -- HIV-1 Vpr vs. HIV-2 Vpx -- HIV-1 Vpr interaction factors -- Cellular proteins that influence PIC import or action -- HIV-2 -- HIV-2: model system for PIC nuclear import -- Vpx cellular localization -- Cellular localization of LacZ-fusions (1) -- Cellular localization of LacZ-fusions (2) -- Alignment of HIV-2/SIV Vpx amino acids 61-79 -- Identifying residues critical for PIC nuclear import -- Nuclear localization signal of HIV-2 Vpx -- Vpx interaction with Hsp40 -- Heat shock proteins -- Heat shock proteins and viruses -- Vpx interacts with Hsp40/DnaJB6 (1) -- Vpx interacts with Hsp40/DnaJB6 (2) -- DnaJB6 over expression and Vpx packaging -- Hsp40/DnaJB6 enhances Vpx nuclear localization -- DnaJB6 down regulation and PIC nuclear import -- Novel mechanism for Vpx-mediated PIC import -- Nuclear import inhibitors.
Language:
English
