UID:
almafu_9961427399802883
Format:
1 videorecording (51 min., 37 sec.)
,
005137
Content:
Audio-visual presentation: Blood-brain-barrier (BBB) functions, permeability pathways and transporters modulated by vasoactive peptides -- The BBB as a source and target of vasocative peptides -- Angiotensins -- Bradykinin -- Adrenomedullin -- Calcitonin-gene related peptide -- Endothelins -- Natriuretic peptides -- Pituitary adenylate cyclase activating peptide -- Substance P -- Urotensin -- Vasopressin -- Potential use of vasocative peptides as modulators of BBB functions.
Note:
Retrieved April 16, 2024, from https://hstalks.com/bs/767/.
,
Introduction -- Vasoactive peptides -- Specific characteristics of the BBB -- Angiotensins -- Effects of angiotensin II -- Angiotensins and the BBB -- Effects of other angiotensins -- Angiotensinogen-deficient mice -- BBB and renin-angiotensin system -- Bradykinin -- Effects of bradykinin -- B2 agonist transiently opens the BBB -- Calcitonin peptide superfamily -- Heterodimeric receptors for CGRP and AM -- Adrenomedullin -- Primary cultures of the BBB cells -- Adrenomedullin production -- BBB model based on cell culture -- Astrocytes induce AM secretion from CEC -- AM concentration in the cerebral circulation -- AM acts mostly in autocrine or paracrine manner -- AM increases intracellular cAMP level in CEC -- AM increases TEER in brain endothelial cells -- Effect of chronic AM treatment on TEER -- Effects of AM on cerebral endothelial permeability -- AM activates P-glycoprotein efflux pump in CEC -- AM protects against oxidative damage in CEC -- Summary: AM and the BBB -- AM and the BBB model -- AM regulates endothelial permeability -- Calcitonin-gene related peptide -- CGRP overexpression in brain -- CGRP and the BBB -- Endothelins family -- The effects of endothelins -- Endothelins and the BBB -- Endothelins and BBB efflux pumps -- Natriuretic peptides (NPs) -- The effects of natriuretic peptides -- Natriuretic peptides and the BBB -- Pituitary adenylate cyclase activating peptide -- Effects of PACAP -- PACAP increases tightness of the barrier in CEC -- Substance P -- Effects of substance P -- Substance P and the BBB -- Urotensin -- Vasopressin -- Effects of vasopressin -- AVP stimulates the BBB Na-K-Cl cotransport -- Summary -- Acknowledgements.
Language:
English
