UID:
almafu_9958070469702883
Format:
1 online resource (171 p.)
ISBN:
3-318-00600-9
Series Statement:
Chemical immunology ; vol. 77
Content:
Catalytic antibodies have attracted attention because they can combine exquisite specificity with permanent and potent antigen inactivation. The field has enjoyed a renaissance in recent years due to the discovery of antibodies with comparatively efficient peptidase and nuclease activities. In principle, antibody catalysis could serve as a platform technology for curing hitherto intractable human diseases, a potential which is exemplified by the availability of catalysts capable of cleaving biologically important targets such as HIV coat proteins. Equally important, catalytic antibodies to physiologically important target autoantigens have been identified in disease. This volume addresses fundamental questions concerning the immunological genesis of the catalytic activity in antibodies, its relationship with classical antigen binding activity, and the biochemical mechanisms involved in catalysis. The contents reflect three main challenges in the field, i.e. to delineate the biological functions of catalytic antibodies in autoimmune disease; to isolate therapy-grade antibody catalysts with sufficient specificity and turnover to permit rapid removal of microbial and tumor antigens; and to develop immunogens that recruit immature catalyst-producing B cells into the clonal selection pathway and induce adaptive improvements of the catalytic function. Well-edited and up-to-date, this book reviews the current knowledge in the field and explores ways by which natural and engineered catalytic activities can be harnessed for medical applications. It should therefore be of special interest to immunologists, biochemists, biotechnologists, rheumatologists and pathologists.
Note:
Description based upon print version of record.
,
Proteolytic antibodies: origins, selection and induction -- Catalytic activity of antibody light chain to gp41: a consideration of refolding in relation to activation mechanism -- Catalyst desgin for reactions with multiple transition states -- Catalytic antibodies in autoimmune mice -- Catalysis by anti-idiotypic antibodies -- Catalytic activities and functional effects of Bence Jones proteins -- Factor VIII inhibitor with catalytic activity towards factor VIII -- Prothrombin cleaving antibody light chains -- Disease association and cytotoxic effects of DNA-hydrolyzing autoantiobodies.
,
English
Additional Edition:
ISBN 3-8055-7099-6
Language:
English
